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West China Hospital of Sichuan University

4 ARTICLES PUBLISHED IN JoVE

Bioengineering

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Meihua Wan^1,2, Pouya Amrollahi^2,3, Dali Sun⁴, Christopher Lyon^2,3, Tony Y. Hu^2,3

¹Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, ²Virginia G. Piper Biodesign Center for Personalized Diagnostics, The Biodesign Institute, Arizona State University, ³School of Biological and Health Systems Engineering, Arizona State University, ⁴Department of Electrical and Computer Engineering, North Dakota State University

Clinical translation of exosome-derived biomarkers for diseased and malignant cells is hindered by the lack of rapid and accurate quantification methods. This report describes the use of low-magnification dark-field microscope images to quantify specific exosome subtypes in small volume serum or plasma samples.

Medicine

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

Ye Tian¹, Jingqiang Zhu², Lei Zhang³, Lichao Mou³, Xiaoxiang Zhu³, Yilei Shi³, Buyun Ma¹, Wanjun Zhao²

¹Department of Ultrasonography, West China Hospital of Sichuan University, ²Department of Thyroid Surgery, West China Hospital of Sichuan University, ³MedAI Technology (Wuxi) Co. Ltd.

Here, a new model for thyroid nodule detection in ultrasound images is proposed, which uses Swin Transformer as the backbone to perform long-range context modeling. Experiments prove that it performs well in terms of sensitivity and accuracy.

Immunology and Infection

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Yuanfan Qian^1,2, Linye He^1,2, Anping Su^1,2, Yiguo Hu³, Jingqiang Zhu¹

¹Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, ²The Laboratory of Thyroid and Parathyroid Disease, West China Hospital of Sichuan University, ³State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center

Several types of animal models of Hashimoto's thyroiditis have been established, as has spontaneous autoimmune thyroiditis in the NOD mouse. H-2h4 mice are a simple and reliable model for HT induction. This article describes this approach and evaluates the pathological process for a better understanding of the SAT murine model.

Neuroscience

Manual Segmentation of the Human Choroid Plexus Using Brain MRI

Deepthi Bannai^*1,2, Yuan Cao^*3,4, Matcheri Keshavan^1,2, Martin Reuter^5,6,7, Paulo Lizano^1,2,8

¹Department of Psychiatry, Beth Israel Deaconess Medical Center, ²Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, ³Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, ⁴Department of Psychiatry and Psychotherapy, Jena University Hospital, ⁵AI in Medical Imaging, German Center for Neurodegenerative Diseases (DZNE), ⁶A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, ⁷Department of Radiology, Harvard Medical School, ⁸Department of Psychiatry, Harvard Medical School

Despite the crucial role of the choroid plexus in the brain, neuroimaging studies of this structure are scarce due to the lack of reliable automated segmentation tools. The present protocol aims to ensure gold-standard manual segmentation of the choroid plexus that can inform future neuroimaging studies.