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Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM

1 ARTICLES PUBLISHED IN JoVE

Biology

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Silvia Murillo-Cuesta^*1,2,3, Néstor Vallecillo^*1, Rafael Cediel^1,2,4, Adelaida M. Celaya^1,2, Luis Lassaletta^3,5, Isabel Varela-Nieto^1,2,3, Julio Contreras^1,2,4

¹Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM, ²Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), ³Instituto de Investigación Sanitaria La Paz (IdiPAZ), ⁴Facultad de Veterinaria, Universidad Complutense de Madrid, ⁵Departmento de Otorrino laringología, Hospital Universitario La Paz

Two microsurgery approaches for local drug delivery to the inner ear are described here and compared in terms of impact on hearing parameters, cochlear cytoarchitecture and expression of inflammatory markers.