High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination LearningAngela Kolodziej 1, Karl-Heinz Smalla 1, Sandra Richter 2, Alexander Engler 1, Rainer Pielot 1,3, Daniela C. Dieterich 3, Wolfgang Tischmeyer 1, Michael Naumann 2, Thilo Kähne 2
1Leibniz Institute for Neurobiology (LIN), 2Institute of Experimental Internal Medicine, Medical School, Otto von Guericke University Magdeburg, 3Institute of Pharmacology and Toxicology, Medical School, Otto von Guericke University
The identification of molecules and pathways controlling synaptic plasticity and memory is still a major challenge in neuroscience. Here, a workflow is described addressing the relative quantification of synaptic proteins supposedly involved in the molecular reorganization of synapses during learning and memory consolidation in an auditory learning paradigm.
