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First Affiliated Hospital of Zhejiang Chinese Medical University

1 ARTICLES PUBLISHED IN JoVE

JoVE Core

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Yang Zhang^*1, Lifeng Shen^*2, Ping'er Wang³, Weixing Xi⁴, Zhongming Yu¹, Xiaowen Huang¹, Xuping Wang¹, Dan Shou¹

¹Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, ²Department of Orthopaedic Surgery, Tongde Hospital of Zhejiang Province, ³Institute of Orthopaedics and Traumatology, First Affiliated Hospital of Zhejiang Chinese Medical University, ⁴Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province

This study presents an improved rabbit model infected with Staphylococcus aureus by blocking the same amount of bacteria in bone marrow. Vancomycin loaded calcium sulphate and autogenous bone are used for antibiotic and bone repair treatment. The protocol could be helpful for studying bone infection and regeneration.