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Texas A&M Institute for Genomic Medicine

1 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals

Jingshu Chen^*2, Lei Zhong^*1, Jing Wu¹, Sui Ke², Benjamin Morpurgo³, Andrei Golovko³, Nengtai Ouyang⁴, Yuxiang Sun², Shaodong Guo², Yanan Tian^1,2

¹Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agriculture University, ²Texas A&M University, ³Texas A&M Institute for Genomic Medicine, ⁴Sun Yat-Sen Memorial Hospital

Here we present a protocol to isolate mouse pancreatic islet cells for screening the ROS inductions by the xenobiotics in order to identify the potential diabetogenic xenobiotic chemicals.