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Agilent Technologies Inc.

1 ARTICLES PUBLISHED IN JoVE

Chemistry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Meera Shanmuganathan¹, Sabrina Macklai¹, Clara Barrenas Cárdenas¹, Zachary Kroezen¹, Marcus Kim², William Zizek³, Howard Lee³, Philip Britz-McKibbin¹

¹Department of Chemistry and Chemical Biology, McMaster University, ²Agilent Technologies Inc., ³Seroclinix Corporation

Here we describe a high-throughput method for comprehensive drug surveillance that allows for the improved resolution and detection of large panels of drugs of abuse and their metabolites, with quality control based on multisegment injection-capillary electrophoresis-mass spectrometry.