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Center for Scientific Research and Higher Education at Ensenada

1 ARTICLES PUBLISHED IN JoVE

Cancer Research

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Cinthia N. Cuero¹, Brenda Iduarte¹, Patricia Juárez¹

¹Biomedical Innovation Department, Center for Scientific Research and Higher Education at Ensenada

The ex vivo culture of bone explants can be a valuable tool for the study of bone physiology and the potential evaluation of drugs in bone remodeling and bone diseases. The presented protocol describes the preparation and culture of calvarias isolated from newborn mice skulls, as well as its applications.