A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in MiceHyeonwi Son 1, Ju Hwan Yang 2, Hyun Joon Kim *1, Dong Kun Lee *3
1Department of Anatomy and Convergence Medical Sciences, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University Medical School, 2Department of Biological Sciences, Pusan National University, 3Department of Physiology and Convergence Medical Sciences, Institute of Health Sciences, Gyeongsang National University Medical School
This article provides a simplified and standardized protocol for induction of depressive-like behavior in chronically immobilized mice by using a restrainer. In addition, behavior and physiological techniques to verify induction of depression are explained.
