Cisterna Magna Injection Approach for the Treatment of Leptomeningeal Metastatic Brain TumorsZhenhua Xu 1, Najiba Murad 1, Yanxin Pei 1
1Center for Cancer and Immunology Research, Children’s Research Institute, Children’s National Medical Center
This protocol presents a straightforward procedure that enables direct intrathecal delivery of agents to cerebrospinal fluid without operative damage to the skull or brain parenchyma. This approach provides a solution to deliver molecules that could not otherwise cross the blood-brain barrier or blood-cerebrospinal fluid barrier to treat leptomeningeal metastatic disease.
