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Center for Nanotechnology Innovation@NEST CNI@NEST

1 ARTICLES PUBLISHED IN JoVE

Biology

Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy

Gianmarco Ferri¹, Fabio Azzarello¹, Francesca D'Autilia², Francesco Cardarelli¹

¹NEST Laboratory, Scuola Normale Superiore, ²Center for Nanotechnology Innovation@NEST CNI@NEST

Imaging-derived mean square displacement (iMSD) analysis is applied to macropinosomes to highlight their intrinsic time-evolving nature in terms of structural and dynamic properties. Macropinosomes are then compared to insulin secretory granules (ISGs) as a reference for subcellular structures with time-invariant average structural/dynamic properties.