A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral MicrodialysisIan O. Massé 1, Luc Moquin 2, Chloé Provost 1, Samuel Guay 1, Alain Gratton 2, Louis De Beaumont 1
1Research Center, Hôpital du Sacré-Cœur de Montréal, 2Research Center, Douglas Institute
Neurotransmitter alteration is a mechanism of neural dysfunction that occurs after concussion and contributes to the sometimes-catastrophic long-term consequences. This rat model combines microdialysis, allowing in vivo neurotransmitter quantification, with a weight-drop technique exerting rapid acceleration and deceleration of the head and torso, an important factor of human craniocerebral trauma.
