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A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis

DOI :

10.3791/59585-v

8:45 min

July 12th, 2019

July 12th, 2019

8,280 Views

1Research Center, Hôpital du Sacré-Cœur de Montréal, 2Research Center, Douglas Institute

Neurotransmitter alteration is a mechanism of neural dysfunction that occurs after concussion and contributes to the sometimes-catastrophic long-term consequences. This rat model combines microdialysis, allowing in vivo neurotransmitter quantification, with a weight-drop technique exerting rapid acceleration and deceleration of the head and torso, an important factor of human craniocerebral trauma.

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Concussion Model

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