Brett Nixon

Rabbit epididymal secretory proteins. I. Characterization and hormonal regulation.

Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells.

Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition.

Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction.

The role of molecular chaperones in mouse sperm-egg interactions.

Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa.

The identification of mouse sperm-surface-associated proteins and characterization of their ability to act as decapacitation factors.

Role of the epididymis in sperm competition.

Proteomic changes in mammalian spermatozoa during epididymal maturation.

Molecular and functional characterization of the rabbit epididymal secretory protein 52, REP52.

Investigation of the role of SRC in capacitation-associated tyrosine phosphorylation of human spermatozoa.

Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse.

Genome analysis of the platypus reveals unique signatures of evolution.

Composition and significance of detergent resistant membranes in mouse spermatozoa.

DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress.

The biological significance of detergent-resistant membranes in spermatozoa.

Elucidation of the signaling pathways that underpin capacitation-associated surface phosphotyrosine expression in mouse spermatozoa.

New insights into sperm physiology and pathology.

Sperm-zona pellucida interaction: molecular mechanisms and the potential for contraceptive intervention.

Cellular mechanisms regulating sperm-zona pellucida interaction.

Monotremes provide a key to understanding the evolutionary significance of epididymal sperm maturation.

Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae.

Proteomic and functional analysis of human sperm detergent resistant membranes.

The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction.

Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity.

The role of molecular chaperones in spermatogenesis and the post-testicular maturation of mammalian spermatozoa.

A unique combination of male germ cell miRNAs coordinates gonocyte differentiation.

Chronic exposure to acrylamide induces DNA damage in male germ cells of mice.

Proteomic insights into the maturation and capacitation of mammalian spermatozoa.

Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.

The function of chaperone proteins in the assemblage of protein complexes involved in gamete adhesion and fusion processes.

The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition.

Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition.

Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro.

Sperm capacitation: a distant landscape glimpsed but unexplored.

Capacitation in the presence of methyl-β-cyclodextrin results in enhanced zona pellucida-binding ability of stallion spermatozoa.

Post-testicular sperm maturation and identification of an epididymal protein in the Japanese quail (Coturnix coturnix japonica).

The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets.

Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure.

Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation.

The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition.

The 12 (th) International Symposium on Spermatology.

Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?

Novel characterization of the HSPA2-stabilizing protein BAG6 in human spermatozoa.

Next Generation Sequencing Analysis Reveals Segmental Patterns of microRNA Expression in Mouse Epididymal Epithelial Cells.

The microRNA signature of mouse spermatozoa is substantially modified during epididymal maturation.

The impact of oxidative stress on chaperone-mediated human sperm-egg interaction.

Heat Shock Protein member A2 forms a stable complex with angiotensin converting enzyme and protein disulfide isomerase A6 in human spermatozoa.

Assessment of microRNA expression in mouse epididymal epithelial cells and spermatozoa by next generation sequencing.

A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation.

The Australian saltwater crocodile (Crocodylus porosus) provides evidence that the capacitation of spermatozoa may extend beyond the mammalian lineage.

Chronic acrylamide exposure in male mice induces DNA damage to spermatozoa; Potential for amelioration by resveratrol.

Identification of a key role for permeability glycoprotein in enhancing the cellular defense mechanisms of fertilized oocytes.

Data on the concentrations of etoposide, PSC833, BAPTA-AM, and cycloheximide that do not compromise the vitality of mature mouse oocytes, parthenogencially activated and fertilized embryos.

Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome.

Formation and Dissociation of Sperm Bundles in Monotremes.

Biochemical alterations in the oocyte in support of early embryonic development.

Non-surgical sterilisation methods may offer a sustainable solution to feral horse (Equus caballus) overpopulation.

Dynamin 2 is essential for mammalian spermatogenesis.

Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse.

Inhibition of arachidonate 15-lipoxygenase prevents 4-hydroxynonenal-induced protein damage in male germ cells.

Epididymal CYP2E1 plays a critical role in acrylamide-induced DNA damage in spermatozoa and paternally mediated embryonic resorptions†.

Heat Shock Protein A2 (HSPA2): Regulatory Roles in Germ Cell Development and Sperm Function.

Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.

Electrophilic aldehyde products of lipid peroxidation selectively adduct to heat shock protein 90 and arylsulfatase A in stallion spermatozoa.

The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte.

Analysis of the small non-protein-coding RNA profile of mouse spermatozoa reveals specific enrichment of piRNAs within mature spermatozoa.

Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.

Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage.

Heat exposure induces oxidative stress and DNA damage in the male germ line.

Characteristics of the Epididymal Luminal Environment Responsible for Sperm Maturation and Storage.

Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress.

Improved methods of DNA extraction from human spermatozoa that mitigate experimentally-induced oxidative DNA damage.

Mouse quiescin sulfhydryl oxidases exhibit distinct epididymal luminal distribution with Segment-Specific sperm surface associations.

Double Strand Break DNA Repair occurs via Non-Homologous End-Joining in Mouse MII Oocytes.

Proteomic profiling of crocodile spermatozoa refutes the tenet that post-testicular maturation is restricted to mammals.