establishment-characterization-small-bowel-neuroendocrine-tumor

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids

Small bowel neuroendocrine tumors (SBNETs) are rare cancers originating from enterochromaffin cells of the gut. Research in this field has been limited ...

University of Iowa Carver College of Medicine

Tumor grade is an important predictor of survival in gastroenteropancreatic (GEP) neuroendocrine tumors (NETs), as determined by Ki-67 expression and mitotic rate. NETs generally grow indolently, but some cells may acquire traits facilitating metastasis. It is unclear how frequently metastases differ in grade from their primary tumors, and whether increasing grade in metastases affects prognosis.

Increased Grade in Neuroendocrine Tumor Metastases Negatively Impacts Survival.

Small bowel neuroendocrine tumors (SBNETs) present frequently with metastases, yet little is known about the molecular basis of this progression. This study sought to identify the serial differential expression of genes between normal small bowel, primary small bowel neuroendocrine tumors, and liver metastases.

Changes in gene expression in small bowel neuroendocrine tumors associated with progression to metastases.

The small bowel and pancreas are the most common primary sites of neuroendocrine tumors (NETs) giving rise to metastatic disease. Some patients with small bowel NETs (SBNETs) present with synchronous or metachronous pancreatic NETs (PNETs), and it is unclear whether these are separate primaries or metastases from one site to the other.

Article	Year
Increased Grade in Neuroendocrine Tumor Metastases Negatively Impacts Survival. Annals of surgical oncology\| PubMed ID: 28560597	2017
Changes in gene expression in small bowel neuroendocrine tumors associated with progression to metastases. Surgery\| PubMed ID: 29154080	2018
The Pancreas as a Site of Metastasis or Second Primary in Patients with Small Bowel Neuroendocrine Tumors. Annals of surgical oncology\| PubMed ID: 31011904	2019

Guiying Li

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