1Department of Surgery, University of Minnesota, 2School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, 3Cardiology, Richmond VA Medical Center, 4Department of Research Service, Center for Veterans Research and Education, Veterans Affairs Health Care System, 5Department of Neuroscience, University of Minnesota
Summary
This study presents a surgical porcine model of chronic myocardial ischemia due to progressive coronary artery stenosis, resulting in impaired cardiac function without infarction. Following ischemia, animals undergo off-pump coronary artery bypass graft with epicardial placement of stem cells-derived exosomes-laden collagen patch. This adjunctive therapy improves myocardial function and recovery.
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