Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

597 Views

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05:25 min

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September 15th, 2023

DOI :

10.3791/65553-v

September 15th, 2023

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Rishav Aggarwal¹, Annie Shao¹, Koray N. Potel², Laura Hocum Stone¹, Cory Swingen¹, Christin Wright¹, Edward O. McFalls³, Tammy A. Butterick⁴^,⁵, Rosemary F. Kelly¹

¹Department of Surgery, University of Minnesota, ²School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, ³Cardiology, Richmond VA Medical Center, ⁴Department of Research Service, Center for Veterans Research and Education, Veterans Affairs Health Care System, ⁵Department of Neuroscience, University of Minnesota

Summary

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Surgical Porcine Model

Chronic Myocardial Ischemia

Exosome laden Collagen Patch

Coronary Artery Bypass Graft CABG

Left Internal Mammary Artery LIMA

Left Anterior Descending LAD Artery

Mitochondrial Restoration

Hibernating Myocardium HIB

Cellular Mechanisms

Coronary Artery Disease CAD

Revascularization

Ischemic Tissue Recovery

Chapters in this video

0:00

Introduction

0:02

FEATURETTE START

0:45

1 second of faded 25% JoVE Logo at TAIL.

1:05

Off‐Pump Coronary Artery Bypass Graft Surgery for Preparation of Porcine Model of Chronic Myocardial Ischemia

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