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Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

DOI :

10.3791/50978-v

December 24th, 2013

December 24th, 2013

26,656 Views

1Research and Development Service, John D. Dingell VA Medical Center and Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine

Disease, head injury, genetic modifications, and treatment of mice with drugs can have profound effects on behavior. Utilizing well-characterized and validated approaches such as marble burying and nestlet shredding, compulsive-like behaviors can be documented accurately in mice as models of human obsessive-compulsive disorder and autism spectrum disorder.

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