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A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

DOI :

10.3791/53951-v

May 31st, 2016

May 31st, 2016

14,169 Views

1Department of Neurology, University Hospital Wuerzburg, 2Institute of Anatomy and Cell Biology, University Wuerzburg

Deep brain stimulation (DBS) is an effective treatment option for Parkinson's disease. We established a study design to screen novel stimulation paradigms in rats. The protocol describes the use of the staircase test and cylinder test for motor outcome assessment in DBS treated hemiparkinsonian rats.

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