Formulation of GNP/PKCi and Assessment of GNP/PKCi Hybrid Solubility
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Results: Analysis of the Gold Nanoparticle Protein Kinase C-delta Inhibitor
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Conclusion
Transcription
Our unique drug delivery system, which uses 20 nanometer gold particles in two specific short peptides, can stabilize gold nano particles in physiological solution and enhance its cellular uptake, and thus, effectively deliver peptide-based or oth
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We have previously used a gold nanoparticle peptide hybrid to intravenously deliver a synthetic peptide, protein kinase C-delta inhibitor, which reduced ischemia-reperfusion-induced acute lung injury. Here we show the detailed protocol of the drug formulation. Other intracellular peptides can be formulated similarly.