scanning-light-scattering-profiler-slps-based-methodology-to

Scanning Light Scattering Profiler (SLPS) Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses

The scanning light scattering profiler (SLSP) methodology has been developed for the full-angle quantitative evaluation of forward and backward light ...

U.S. Food and Drug Administration

Nanoantennas pour les ions: Silicium microcolonne tableaux collecter de la lumi&#xE8;re &#xE0; partir d&#x26;#39;une impulsion laser pour produire des ions. Le syst&#xE8;me se comporte comme un r&#xE9;seau d&#x26;#39;antennes quasi-p&#xE9;riodique avec des rendements d&#x26;#39;ions qui montrent la d&#xE9;pendance profond sur le plan de polarisation et l&#x26;#39;angle d&#x26;#39;incidence du faisceau laser. Sources d&#x26;#39;ions photoniques promettre pour permettre un meilleur contr&#xF4;le de la production d&#x26;#39;ions sur une int&#xE9;gration des micro-et nanom&#xE9;trique et direct avec des dispositifs d&#x26;#39;analyse miniaturis&#xE9;s.

La production d&#x26;#39;ions &#xE0; partir de silicium Nanophotonique microcolonne tableaux

Nanoantennen f&uuml;r Ionen: Silicon Microcolumn Arrays Ernte Licht aus einem Laserpuls Ionen produzieren. Das System verh&auml;lt sich wie ein Ei-Antenne-Array mit Ionen-Ertr&auml;gen, die tiefgreifende Abh&auml;ngigkeit auf der Ebene der Polarisation und der Einfallswinkel des Laserstrahls zu zeigen. Photonische Ionenquellen Versprechen, verbesserte Kontrolle der Ion-Produktion auf einem Mikro- und Nanometerbereich und direkte Integration mit miniaturisierten analytischen Ger&auml;ten aktivieren.

Nanophotonischen Ion Produktion von Silizium-Microcolumn-Arrays.

Nanoantennas per gli ioni: matrici di silicio microcolonna raccolgono luce da un impulso laser per produrre ioni. Il sistema si comporta come un array periodico dell&#39;antenna con rendimenti di ioni che mostrano profonda dipendenza sul piano di polarizzazione e l&#39;angolo di incidenza del fascio laser. Sorgenti di ioni fotoniche promettono di attivare un controllo maggiore della produzione di ioni su un micro - e su scala nanometrica e integrazione diretta con dispositivi analitici miniaturizzati.

Nanofotonico produzione di ioni da matrici di silicio microcolonna.

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Nanoantennas for ions: Silicon microcolumn arrays harvest light from a laser pulse to produce ions. The system behaves like a quasi-periodic antenna array with ion yields that show profound dependence on the plane of polarization and the angle of incidence of the laser beam. Photonic ion sources promise to enable enhanced control of ion production on a micro- and nanometer scale and direct integration with miniaturized analytical devices.

Nanophotonic ion production from silicon microcolumn arrays.

&#x30A4;&#x30AA;&#x30F3;&#x306E;Nanoantennas&#xFF1A;&#x30B7;&#x30EA;&#x30B3;&#x30F3;&#x30DF;&#x30AF;&#x30ED;&#x30A2;&#x30EC;&#x30A4;&#x306F;&#x3001;&#x30A4;&#x30AA;&#x30F3;&#x3092;&#x751F;&#x6210;&#x3059;&#x308B;&#x305F;&#x3081;&#x306E;&#x30EC;&#x30FC;&#x30B6;&#x30FC;&#x30D1;&#x30EB;&#x30B9;&#x304B;&#x3089;&#x306E;&#x5149;&#x3092;&#x53CE;&#x7A6B;&#x3002;&#x30B7;&#x30B9;&#x30C6;&#x30E0;&#x306F;&#x3001;&#x504F;&#x5149;&#x3068;&#x30EC;&#x30FC;&#x30B6;&#x30D3;&#x30FC;&#x30E0;&#x306E;&#x5165;&#x5C04;&#x89D2;&#x306E;&#x5E73;&#x9762;&#x4E0A;&#x306E;&#x6DF1;&#x9060;&#x306A;&#x4F9D;&#x5B58;&#x6027;&#x3092;&#x793A;&#x3059;&#x30A4;&#x30AA;&#x30F3;&#x53CE;&#x7387;&#x3067;&#x6E96;&#x5468;&#x671F;&#x7684;&#x30A2;&#x30EC;&#x30FC;&#x30A2;&#x30F3;&#x30C6;&#x30CA;&#x306E;&#x3088;&#x3046;&#x306B;&#x52D5;&#x4F5C;&#x3057;&#x307E;&#x3059;&#x3002;&#x30D5;&#x30A9;&#x30C8;&#x30CB;&#x30C3;&#x30AF;&#x30A4;&#x30AA;&#x30F3;&#x6E90;&#x306F;&#x5C0F;&#x578B;&#x306E;&#x5206;&#x6790;&#x88C5;&#x7F6E;&#x3068;&#x30DE;&#x30A4;&#x30AF;&#x30ED;&#xB7;&#x30CA;&#x30CE;&#x30B9;&#x30B1;&#x30FC;&#x30EB;&#x3068;&#x76F4;&#x63A5;&#x7D71;&#x5408;&#x306B;&#x30A4;&#x30AA;&#x30F3;&#x751F;&#x6210;&#x306E;&#x62E1;&#x5F35;&#x30B3;&#x30F3;&#x30C8;&#x30ED;&#x30FC;&#x30EB;&#x3092;&#x6709;&#x52B9;&#x306B;&#x3059;&#x308B;&#x3053;&#x3068;&#x3092;&#x7D04;&#x675F;&#x3057;&#x307E;&#x3059;&#x3002;

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&#xC774;&#xC628;&#xC5D0; &#xB300; &#xD55C; Nanoantennas: &#xC2E4;&#xB9AC;&#xCF58; microcolumn &#xBC30;&#xC5F4; &#xC218;&#xD655; &#xC0DD;&#xC0B0; &#xC774;&#xC628; &#xB808;&#xC774;&#xC800; &#xD384;&#xC2A4;&#xC5D0;&#xC11C; &#xBE5B;. &#xC774;&#xC628; &#xC218;&#xC775;&#xB960; &#xC591;&#xADF9; &#xD654; &#xD3C9;&#xBA74;&#xACFC; &#xB808;&#xC774;&#xC800; &#xBE54; &#xAC01;&#xB3C4; &#xBC1C;&#xC0DD;&#xB960;&#xC5D0; &#xB300; &#xD55C; &#xC2EC;&#xC624;&#xD55C; &#xC758;&#xC874;&#xB3C4; &#xB098;&#xD0C0;&#xB0B4;&#xB294; quasi-periodic &#xC548;&#xD14C;&#xB098; &#xBC30;&#xC5F4; &#xCC98;&#xB7FC; &#xB3D9;&#xC791; &#xD558;&#xB294; &#xC2DC;&#xC2A4;&#xD15C;. &#xAD11;&#xD559;&#xC801; &#xC774;&#xC628; &#xC18C;&#xC2A4; &#xC18C;&#xD615; &#xBD84;&#xC11D; &#xC7A5;&#xCE58;&#xB294; &#xB9C8;&#xC774;&#xD06C;&#xB85C;-&#xB098;&#xB178;&#xBBF8;&#xD130; &#xADDC;&#xBAA8;&#xC640; &#xC9C1;&#xC811; &#xD1B5;&#xD569;&#xC5D0; &#xC774;&#xC628; &#xC0DD;&#xC0B0;&#xC758; &#xD5A5;&#xC0C1; &#xB41C; &#xC81C;&#xC5B4;&#xB97C; &#xC0AC;&#xC6A9; &#xD558;&#xB3C4;&#xB85D; &#xC57D;&#xC18D; &#xB4DC;&#xB9BD;&#xB2C8;&#xB2E4;.

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Las nanoantenas de iones: Silicon microcolumna matrices de captar la luz de un l&#xE1;ser de pulso para producir iones. El sistema se comporta como una red de antenas cuasi-peri&#xF3;dica con rendimientos de iones que muestran la dependencia profundo en el plano de polarizaci&#xF3;n y el &#xE1;ngulo de incidencia del haz l&#xE1;ser. Las fuentes de iones Fot&#xF3;nicas prometo que permitan un mejor control de la producci&#xF3;n de iones en una integraci&#xF3;n de micro y escala nanom&#xE9;trica y directa con los dispositivos miniaturizados de an&#xE1;lisis.

Producci&#xF3;n de iones de Nanofot&#xF3;nica de Silicon microcolumna matrices

Interactions between pulsed laser radiation and nanostructured materials, with dimensions ranging from 1 nm to 500 nm, can result in enhanced desorption and ionization of organic and biomolecular adsorbates. When the critical dimensions of the nanostructures fall below the characteristic lengths for the involved transport processes, novel regimes of ion production are observed. Systems with dimensions commensurate with the wavelength of the laser radiation are the basis of photonic ion sources with unique properties, including polarization dependent ion yields and fragmentation. The main characteristics of these systems are often governed by altered modes of transport, e.g., ballistic vs. diffusive, energy confinement, plasmon resonances, and local field enhancements. Some structures offer control over the internal energy and the active fragmentation channels for the produced ions. Emerging applications of photonic ion sources in mass spectrometry benefit from ultrahigh sensitivity, a wide dynamic range for detection and quantitation, and a broad coverage of adsorbates ranging from small organic molecules to biopolymers, as well as to highly complex samples like single cells.

Laser-nanostructure interactions for ion production.

Recent mechanistic studies have indicated that at subwavelength post diameters and selected aspect ratios nanopost arrays (NAPA) exhibit ion yield resonances ( Walker , B. N. , Stolee , J. A. , Pickel , D. L. , Retterer , S. T. , and Vertes , A. J. Phys. Chem. C 2010 , 114 , 4835 - 4840 ). In this contribution we explore the analytical utility of these optimized structures as matrix-free platforms for laser desorption ionization mass spectrometry (LDI-MS). Using NAPA, we show that high ionization efficiencies enable the detection of ultratrace amounts of analytes (e.g., ∼800 zmol of verapamil) with a dynamic range spanning up to 4 orders of magnitude. Due to the clean nanofabrication process and the lack of matrix material, minimal background interferences are present in the low-mass range. We demonstrate that LDI from NAPA ionizes a broad class of small molecules including pharmaceuticals, natural products, metabolites, and explosives. Quantitation of resveratrol in red wine samples shows that the analysis of targeted analytes in complex mixtures is feasible with minimal sample preparation using NAPA-based LDI. We also describe how multiple metabolite species can be directly detected in single yeast cells deposited on the NAPA chip. Twenty-four metabolites, or 4% of the yeast metabolome, were identified in the single-cell spectra.

Nanophotonic ionization for ultratrace and single-cell analysis by mass spectrometry.

Metabolic differences in microbial cell populations revealed by nanophotonic ionization.

Optical power properties of lenses and materials in general can be influenced by thermal changes of the material and surrounding medium. In the case of an intraocular lens (IOL) implant, the spherical power (SP), cylinder power, (CP), astigmatism, and spherical aberration are the critical fundamental properties that can significantly impact its efficacy. Directly evaluating how changes in temperature can affect these optical properties may show the importance of considering temperature when evaluating IOL optical characteristics. In this paper, we present a quantitative study on evaluating the impact of environmental temperature changes on IOL fundamental optical properties by testing IOL samples with different materials (e.g., hydrophobic and hydrophilic) and designs (e.g., monofocal and toric) to better encompass types of IOLs in conventional use today. The results from this study demonstrate that significant changes are observed as temperatures are changed from room temperature (20°C) to slightly above body temperature (40°C). Findings indicate that evaluating optical properties at arbitrary temperatures could significantly affect the characterization of IOLs that are already near the tolerance thresholds.

Impact of environmental temperature on optical power properties of intraocular lenses.

The design and manufacture of intraocular lenses (IOLs) depend upon the identification and quantitative preclinical evaluation of key optical properties and environmental parameters. The confocal laser method (CLM) is a new technique for measuring IOL optical properties, such as dioptric power, optical quality, refractive index, and geometrical parameters. In comparison to competing systems, the CLM utilizes a fiber-optic confocal laser design that significantly improves the resolution, accuracy, and repeatability of optical measurements. Here, we investigate the impact of changing the beam diameter on the CLM platform for the evaluation of IOL dioptric powers. Due to the Gaussian intensity profile of the CLM laser beam, the changes in focal length and dioptric power associated with changes in beam diameter are well within the tolerances specified in the ISO IOL standard. These results demonstrate some of the advanced potentials of the CLM toward more effectively and quantitatively evaluating IOL optical properties.

Assessing the effect of laser beam width on quantitative evaluation of optical properties of intraocular lens implants.

Glare, glistenings, optical defects, dysphotopsia, and poor image quality are a few of the known deficiencies of intraocular lenses (IOLs). All of these optical phenomena are related to light scatter. However, the specific direction that light scatters makes a critical difference between debilitating glare and a slightly noticeable decrease in image quality. Consequently, quantifying the magnitude and direction of scattered light is essential to appropriately evaluate the safety and efficacy of IOLs. In this study, we introduce a full-angle scanning light scattering profiler (SLSP) as a novel approach capable of quantitatively evaluating the light scattering from IOLs with a nearly 360° view. The SLSP method can simulate in situ conditions by controlling the parameters of the light source including angle of incidence. This testing strategy will provide a more effective nonclinical approach for the evaluation of IOL light scatter.

A novel full-angle scanning light scattering profiler to quantitatively evaluate forward and backward light scattering from intraocular lenses.

To present a proof-of-concept study on the development and implementation of an innovative confocal laser method platform for precise quantitative evaluation of critical optical properties unique to toric intraocular lenses (IOLs).

Confocal laser method for quantitative evaluation of critical optical properties of toric intraocular lenses.

The authors evaluated the potential for ocular damage from optical radiation emitted by Light Emitting Diode (LED) based lamps used for general illumination. Ten LED lamps were randomly selected off the shelf from a local home improvement store. The LEDs were behind diffusers in half of these lamps, while in the other half, the LEDs were clearly visible. In addition, a battery powered LED lantern having a LED source behind a diffuser was measured. The optical radiation emissions from two common incandescent lamps were also measured to compare the relative hazards of LED and incandescent lamps. All lamp samples were evaluated in accordance with procedures specified in the American National Standards Institute/Illuminating Engineering Society of North America (ANSI/IESNA) Standard RP-27.3. For comparison purposes, the lantern and 100 W incandescent lamps were also evaluated according to ANSI RP-27.1. These measurements indicate that no lamp evaluated poses any photobiological hazard, and therefore, all lamps fall in the RP-27.3 category of Exempt Group. However, when evaluated in accordance with RP-27.1, the 100 W incandescent lamp would be classified in Risk Group 1 (low risk), while the LED lantern would be classified in Risk Group 2 (moderate risk).

Bennett N. Walker

Office of Device Evaluation,
Center for Devices and Radiological Health,
Office of Device Evaluation, Center for Devices and Radiological Health

U.S. Food and Drug Administration

Scanning Light Scattering Profiler (SLPS) Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses

Bennett N. Walker

Office of Device Evaluation,Center for Devices and Radiological Health,Office of Device Evaluation, Center for Devices and Radiological Health

U.S. Food and Drug Administration

Scanning Light Scattering Profiler (SLPS) Based Methodology to Quantitatively Evaluate Forward and Backward Light Scattering from Intraocular Lenses

Office of Device Evaluation,
Center for Devices and Radiological Health,
Office of Device Evaluation, Center for Devices and Radiological Health