David C. Spray

C-erbB2/neu transfection induces gap junctional communication incompetence in glial cells.

Changes in the properties of gap junctions during neuronal differentiation of hippocampal progenitor cells.

Calcium waves between astrocytes from Cx43 knockout mice.

Increased intercellular communication in mouse astrocytes exposed to hyposmotic shocks.

Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells.

IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels.

Functional properties of channels formed by the neuronal gap junction protein connexin36.

Wnt-1 regulation of connexin43 in cardiac myocytes.

Intercellular communication in spinal cord astrocytes: fine tuning between gap junctions and P2 nucleotide receptors in calcium wave propagation.

Evidence for secretory pathway localization of a voltage-dependent anion channel isoform.

Cytokine regulation of gap junction connectivity: an open-and-shut case or changing partners at the Nexus?

Calmodulin kinase pathway mediates the K+-induced increase in Gap junctional communication between mouse spinal cord astrocytes.

Quinine blocks specific gap junction channel subtypes.

Connexin family members target to lipid raft domains and interact with caveolin-1.

pH-dependent intramolecular binding and structure involving Cx43 cytoplasmic domains.

Formation of the gap junction nexus: binding partners for connexins.

Prospects for rational development of pharmacological gap junction channel blockers.

Acute downregulation of Cx43 alters P2Y receptor expression levels in mouse spinal cord astrocytes.

Closure of gap junction channels by arylaminobenzoates.

Gap junctions mediate bystander cell death in developing retina.

Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy.

Array analysis of gene expression in connexin-43 null astrocytes.

Kinetics of protein-protein interactions of connexins: use of enzyme linked sorbent assays.

Following tracks of hemichannels.

Regulation of connexin43 protein complexes by intracellular acidification.

Alterations of intercellular communication in neonatal cardiac myocytes from connexin43 null mice.

Gene expression alterations in connexin null mice extend beyond the gap junction.

pH-dependent dimerization of the carboxyl terminal domain of Cx43.

Potent block of Cx36 and Cx50 gap junction channels by mefloquine.

The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: a "bumper-car" model.

Genes controlling multiple functional pathways are transcriptionally regulated in connexin43 null mouse heart.

Regulation of connexin43-protein binding in astrocytes in response to chemical ischemia/hypoxia.

Connexin43, the major gap junction protein of astrocytes, is down-regulated in inflamed white matter in an animal model of multiple sclerosis.

Sensitivity of the brain transcriptome to connexin ablation.

A developmental switch in the expression of aquaporin-4 and Kir4.1 from horizontal to Müller cells in mouse retina.

A stochastic two-dimensional model of intercellular Ca2+ wave spread in glia.

Microarray technology in the investigation of diseases of myocardium with special reference to infection.

Cardiac connexins: genes to nexus.

Transcriptomic changes in developing kidney exposed to chronic hypoxia.

Functional connexin "hemichannels": a critical appraisal.

Connexin43 and the brain transcriptome of newborn mice.

Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex.

The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1.

Transfection of mammalian cells with connexins and measurement of voltage sensitivity of their gap junctions.

Connexin-dependent transcellular transcriptomic networks in mouse brain.

Fluid shear stress upregulates vascular endothelial growth factor gene expression in osteoblasts.

Organizational principles of the connexin-related brain transcriptome.

Gap junction and purinergic P2 receptor proteins as a functional unit: insights from transcriptomics.

Aquaporin-4 water channels in enteric neurons.

Trypanosoma cruzi induces changes in cardiac connexin43 expression.

Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia.

Bone marrow cell therapy ameliorates and reverses chagasic cardiomyopathy in a mouse model.

Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection.

Cognitive dysfunction in mice infected with Plasmodium berghei strain ANKA.

Connexin and pannexin mediated cell-cell communication.

Lack of "hemichannel" activity in insulin-producing cells.

Similar transcriptomic alterations in Cx43 knockdown and knockout astrocytes.

Effect of microgravity on gene expression in mouse brain.

Connexins, pannexins, innexins: novel roles of "hemi-channels".

IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway.

Alteration of transcriptomic networks in adoptive-transfer experimental autoimmune encephalomyelitis.

Reciprocal influence of connexins and apical junction proteins on their expressions and functions.

The neuronal connexin36 interacts with and is phosphorylated by CaMKII in a way similar to CaMKII interaction with glutamate receptors.

Effects of ageing and streptozotocin-induced diabetes on connexin43 and P2 purinoceptor expression in the rat corpora cavernosa and urinary bladder.

Trifluoroethanol reveals helical propensity at analogous positions in cytoplasmic domains of three connexins.

Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease).

Pannexin 1: the molecular substrate of astrocyte "hemichannels".

Improved procedures to mine data obtained from spotted cDNA arrays.

Hits and misses from gene expression ratio measurements in cDNA microarray studies.

Cell Therapy in Chagas Disease.

Point mutation in the mouse P2X7 receptor affects intercellular calcium waves in astrocytes.

Automated cell-based assay for screening of aquaporin inhibitors.

Transcriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes.

Astrocytic 'power-grid': Delivery upon neuronal demand.

Bidirectional calcium signaling between satellite glial cells and neurons in cultured mouse trigeminal ganglia.

Modulatory effects of cAMP and PKC activation on gap junctional intercellular communication among thymic epithelial cells.

Chemical induction of cardiac differentiation in p19 embryonal carcinoma stem cells.

The carboxyl-terminal domain of connexin43 is a negative modulator of neuronal differentiation.

Mefloquine blockade of Pannexin1 currents: resolution of a conflict.

Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology.

Trypanosoma cruzi infection results in the reduced expression of caveolin-3 in the heart.

Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi.

Fluid flow-induced soluble vascular endothelial growth factor isoforms regulate actin adaptation in osteoblasts.

Characterization of hTERT-immortalized osteoblast cell lines generated from wild-type and connexin43-null mouse calvaria.

Persistent cognitive and motor deficits after successful antimalarial treatment in murine cerebral malaria.

Focal Inflammation Causes Carbenoxolone-Sensitive Tactile Hypersensitivity in Mice.

Silencing MaxiK activity in corporal smooth muscle cells initiates compensatory mechanisms to maintain calcium homeostasis.

Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells.

Imaging the endothelial glycocalyx in vitro by rapid freezing/freeze substitution transmission electron microscopy.

On the electrophysiological response of bone cells using a Stokesian fluid stimulus probe for delivery of quantifiable localized picoNewton level forces.

Pannexin channels are not gap junction hemichannels.

In vitro motility of liver connexin vesicles along microtubules utilizes kinesin motors.

Optimized labeling of bone marrow mesenchymal cells with superparamagnetic iron oxide nanoparticles and in vivo visualization by magnetic resonance imaging.

Functional and transcriptomic recovery of infarcted mouse myocardium treated with bone marrow mononuclear cells.

Gap junctions and chagas disease.

Two non-vesicular ATP release pathways in the mouse erythrocyte membrane.

Glial cells in (patho)physiology.

Chagas heart disease: report on recent developments.

Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells.

Extracellular K⁺ and astrocyte signaling via connexin and pannexin channels.

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner.

ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes.

Calmodulin dependent protein kinase increases conductance at gap junctions formed by the neuronal gap junction protein connexin36.

Connexin43 and pannexin1 channels in osteoblasts: who is the "hemichannel"?

Mesenchymal bone marrow cell therapy in a mouse model of chagas disease. Where do the cells go?

Identification of a functional prostanoid-like receptor in the protozoan parasite, Trypanosoma cruzi.

Alterations in the Brain Transcriptome in ANKA Infected Mice.

Gap junctions and Bystander Effects: Good Samaritans and executioners.

Promises and pitfalls of a Pannexin1 transgenic mouse line.

Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process.

Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis.

High glucose attenuates shear-induced changes in endothelial hydraulic conductivity by degrading the glycocalyx.

Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require αVβ3 integrin.

Human liver cell trafficking mutants: characterization and whole exome sequencing.

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1.

Connexins modulate autophagosome biogenesis.

Structural order in Pannexin 1 cytoplasmic domains.

Inhibitors of the 5-lipoxygenase pathway activate pannexin1 channels in macrophages via the thromboxane receptor.

Adipocytes in both brown and white adipose tissue of adult mice are functionally connected via gap junctions: implications for Chagas disease.

Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling.

Molecular imaging, biodistribution and efficacy of mesenchymal bone marrow cell therapy in a mouse model of Chagas disease.

Gap junctional communication in health and disease.

Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.

Connexin Type and Fluorescent Protein Fusion Tag Determine Structural Stability of Gap Junction Plaques.

The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins.

Developments in the management of Chagas cardiomyopathy.

Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes.

Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes.

The Einstein-Brazil Fogarty: A decade of synergy.

Effect of mesenchymal stem cells and mouse embryonic fibroblasts on the development of preimplantation mouse embryos.

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria.

P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes.

Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain.

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.

Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain.

Structural and Functional Consequences of Connexin 36 (Cx36) Interaction with Calmodulin.

Gap junctions, pannexins and pain.

Cysteine residues in the cytoplasmic carboxy terminus of connexins dictate gap junction plaque stability.

Osteocyte calcium signals encode strain magnitude and loading frequency in vivo.

Characteristics of Gap Junction Channels in Schwann Cells from Wild-Type and Connexin-Null Mice.

Potential role for a specialized β integrin-based structure on osteocyte processes in bone mechanosensation.

Functional genomic fabrics are remodeled in a mouse model of Chagasic cardiomyopathy and restored following cell therapy.

Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer.

Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model.

Gap junction mediated signaling between satellite glia and neurons in trigeminal ganglia.

Introduction to Connexins and Pannexins in the Healthy and Diseased Nervous System with Thanks to Felikas Bukauskas.

Tubulin-Dependent Transport of Connexin-36 Potentiates the Size and Strength of Electrical Synapses.

Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels.

Stress gates an astrocytic energy reservoir to impair synaptic plasticity.

Cellular Environment Remodels the Genomic Fabrics of Functional Pathways in Astrocytes.

Author Correction: Stress gates an astrocytic energy reservoir to impair synaptic plasticity.

Promotes Transcriptomic Remodeling of the JAK/STAT Signaling and Cell Cycle Pathways in Myoblasts.

Emerging importance of satellite glia in nervous system function and dysfunction.

The dynamic Nexus: gap junctions control protein localization and mobility in distinct and surprising ways.

Author Correction: Emerging importance of satellite glia in nervous system function and dysfunction.

Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice.

Retinal Genomic Fabric Remodeling after Optic Nerve Injury.

The Roles of Calmodulin and CaMKII in Cx36 Plasticity.

Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading.

Glioblastoma-Astrocyte Connexin 43 Gap Junctions Promote Tumor Invasion.

Pannexin-1 channel opening is critical for COVID-19 pathogenesis.

Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability.

Activity and Stability of Panx1 Channels in Astrocytes and Neuroblastoma Cells Are Enhanced by Cholesterol Depletion.

Age-Related Changes in Neurons and Satellite Glial Cells in Mouse Dorsal Root Ganglia.