עבודה זו נתמכה על ידי GM109098 מענק NIH P20, NSF ותכנית WVU ADVANCE חסות (VG), וקרנות סטארט-אפ המחלקתיים WVU.

<ol>
	<li>Dounskaia, N., Wang, W., Sainburg, R. L., Przybyla, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Preferred+directions+of+arm+movements+are+independent+of+visual+perception+of+spatial+directions.">Preferred directions of arm movements are independent of visual perception of spatial directions.</a> Exp. brain Res. 232 (2), 575-586 (2014).</li><li>McIntosh, R. D., Mulroue, A., Brockmole, J. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=How+automatic+is+the+hand&#8217;s+automatic+pilot?+Evidence+from+dual-task+studies.">How automatic is the hand&#8217;s automatic pilot? Evidence from dual-task studies.</a> Exp brain Res. 206 (3), 257-269 (2010).</li><li>Shabbott, B. A., Sainburg, R. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Learning+a+visuomotor+rotation:+simultaneous+visual+and+proprioceptive+information+is+crucial+for+visuomotor+remapping.">Learning a visuomotor rotation: simultaneous visual and proprioceptive information is crucial for visuomotor remapping.</a> Exp. Brain Res. 203 (1), 75-87 (2010).</li><li>Sarlegna, F. R., Sainburg, R. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+roles+of+vision+and+proprioception+in+the+planning+of+reaching+movements.">The roles of vision and proprioception in the planning of reaching movements.</a> Adv. Exp. Med. Biol. 629, 317-335 (2009).</li><li>Lillicrap, T. P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Adapting+to+inversion+of+the+visual+field:+a+new+twist+on+an+old+problem.">Adapting to inversion of the visual field: a new twist on an old problem.</a> Exp. brain Res. 228 (3), 327-339 (2013).</li><li>Saposnik, G., Levin, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Virtual+reality+in+stroke+rehabilitation:+a+meta-analysis+and+implications+for+clinicians.">Virtual reality in stroke rehabilitation: a meta-analysis and implications for clinicians.</a> Stroke. 42 (5), 1380-1386 (2011).</li><li>Robles-Garc&#237;a, V., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Motor+facilitation+during+real-time+movement+imitation+in+Parkinson&#8217;s+disease:+a+virtual+reality+study.">Motor facilitation during real-time movement imitation in Parkinson&#8217;s disease: a virtual reality study.</a> Parkinsonism Relat. Disord. 19 (12), 1123-1129 (2013).</li><li>Gritsenko, V., Kalaska, J. F., Cisek, P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Descending+corticospinal+control+of+intersegmental+dynamics.">Descending corticospinal control of intersegmental dynamics.</a> J. Neurosci. 31 (33), 11968-11979 (2011).</li><li>Shirvalkar, P. R., Shapiro, M. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Design+and+construction+of+a+cost+effective+headstage+for+simultaneous+neural+stimulation+and+recording+in+the+water+maze.">Design and construction of a cost effective headstage for simultaneous neural stimulation and recording in the water maze.</a> J. Vis. Exp. (44), e2155 (2010).</li><li>Kendall, F. P., McCreary, E. K., Provance, P. G., Rodgers, M., Romani, W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> Muscles: Testing and Function With Posture and Pain. , (2005).</li><li>Barbero, M., Merletti, R., Rainoldi, <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Atlas+of+Muscle+Innervation+Zones:+Understanding+Surface+Electromyography+and+Its+Applications.">Atlas of Muscle Innervation Zones: Understanding Surface Electromyography and Its Applications.</a> Springer-Verlag Mailand. , (2012).</li><li>Sliwinska, M. W., Vitello, S., Devlin, J. T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Transcranial+magnetic+stimulation+for+investigating+causal+brain-behavioral+relationships+and+their+time+course.">Transcranial magnetic stimulation for investigating causal brain-behavioral relationships and their time course.</a> J. Vis. Exp. (89), (2014).</li><li>Goss, D. A., Hoffman, R. L., Clark, B. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Utilizing+transcranial+magnetic+stimulation+to+study+the+human+neuromuscular+system.">Utilizing transcranial magnetic stimulation to study the human neuromuscular system.</a> J. Vis. Exp. (59), e3387 (2012).</li><li>Rogers, J., Watkins, K. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Stimulating+the+lip+motor+cortex+with+transcranial+magnetic+stimulation.">Stimulating the lip motor cortex with transcranial magnetic stimulation.</a> J. Vis. Exp. (88), e51665 (2014).</li><li>Ellaway, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Variability+in+the+amplitude+of+skeletal+muscle+responses+to+magnetic+stimulation+of+the+motor+cortex+in+man.">Variability in the amplitude of skeletal muscle responses to magnetic stimulation of the motor cortex in man.</a> Electroencephalogr. Clin. Neurophysiol. Mot. Control. 109 (2), 104-113 (1998).</li></ol>

The authors have no conflicts of interest to declare.

המטרה של מאמר זה היא מתאר שיטה לשילוב VR למחקר של תנועה אנושית ושיטה לסנכרון זרמי נתונים שונים. מציאות מדומה תרחיב את היכולות של חוקרים המנסים לשחזר תרחישי תנועה בעולם אמיתי בסביבת מעבדה. VR שילוב עם שיטות הקלטה וגירוי עצבית-שרירית אחרות יוצר חבילה חזקה של כלי ללימוד מ?...

מציאות וירטואלית (VR) הופכת במהירות כלי מחקר נגיש לשימוש במספר תחומים, כולל המחקר של תנועה אנושית. המחקר של תנועת גפיים העליונה נהנה במיוחד על ידי שילוב VR. מציאות וירטואלית מאפשרת ההתאמה האישית המהירה של פרמטרים ניסיוניים שנועדו לחקור תכונות kinematic ודינמיות מסוימות של שליטת תנועת זרוע. פרמטרים אלה יכולים להיות מותאמים באופן אינדיבידואלי לכל נושא. לדוגמא, את מיקומם של יעדים וירטואליים ניתן לשנותם על מנת להבטיח תנוחת זרוע ראשונית זהה על פני נושאים. מציאות וירטואלית מאפשרת גם המניפולציה של משוב חזותי במהלך ניסויים, שהוא כלי רב ערך במחקר visuomotor 1 - 5. השימוש בסביבות VR מציאותיים עם כלים ביו-מכאניים אחרים גם יאפשר תרחישי תנועה הנטורליסטית שבלבחון דפוסי תנועה. הסדר זה הופך יותר ויותר חשוב ללימוד ותרגול של שיקום לאחר 6,7 מחלות ופציעות. תנועות חיקוי נטורליסטי וסביבות (למשל ביצוע תנועות במטבח וירטואלי) בסביבה קלינית יאפשרו מומחי שיקום לתאר באופן מדויק יותר ליקויים של פרט בהקשר של עולם אמיתי. תיאור ירידת ערך מאוד אישי יאפשר לאסטרטגיות טיפול ממוקדות יותר, ואפשרות להגדיל את היעילות ולהפחית את משך הזמן של שיקום. שילוב VR עם כלים אחרים כגון גירוי מגנטי transcranial (TMS), electromyography משטח (EMG), ולכיד תנועת גוף מלאה, יוצר פלטפורמה חזקה מאוד וגמישה ללימוד השליטה העצבית-שרירית של תנועה בבני אדם. גירוי מגנטי Transcranial הוא שיטה לא פולשנית חזקה של מדידת הרגישות ושלמות פונקציונלית של מסלולים יורדים מנוע (למשל בדרכי corticospinal) דרך respons EMGes כגון מנוע פוטנציאלים מעורר (חברי הפרלמנט האירופי) 8. מערכות ללכוד תנועה תלת-ממדית מודרניות גם יאפשרו לחוקרים ללמוד פעילות עצבית-שרירית יחד עם קינמטיקה תנועה וכתוצאה מכך ודינמיקה. זה מאפשר יצירת מודלים מפורטים מאוד של מערכת השלד והשרירים, כמו גם הבדיקה של השערות לגבי המבנה והתפקוד של בקרים עצביים. מחקרים אלה ירחיבו במערכת הסנסורית האנושית הידע המדעי שלנו ולהוביל לשיפור בטיפול בשרירים ושלד והפרעות נוירולוגיות. עם זאת, בעיה עיקרית עם מערכות רב תכליתיים הוא הסנכרון של זרמים נרשמו בנפרד נתונים (לכידת תנועה למשל, EMG, וכו &#39;). המטרה של פרוטוקול זה היא לתאר הסדר להכללה של מערכות זמינות מסחרי נפוצות להקליט בו זמנית מדידות ביו-מכאניות ופיזיולוגיות בזמן התנועה. חוקרים אחרים תוך שימוש בציוד מיצרנים שונים עשויים להיות לשנות אלמנטים של פרוטוקול זה כדי להתאים לצרכימים הספציפיים שלהם. עם זאת, עקרונות כלליים מפרוטוקול זה עדיין צריכים להיות ישימים.

<table border="0" cellpadding="0" cellspacing="0">
	<tbody>
		<tr>
			<td>Transcranial magnetic stimulator</td>
			<td>Magstim</td>
			<td>N/A</td>
			<td>TMS stimulator and coils</td>
		</tr>
		<tr>
			<td>Impulse X2</td>
			<td>PhaseSpace</td>
			<td>N/A</td>
			<td>Motion capture system</td>
		</tr>
		<tr>
			<td>MA300 Advanced Multi-Channel EMG System</td>
			<td>Motion Lab Systems</td>
			<td>MA300-28</td>
			<td>EMG pre-amplifier and amplifier</td>
		</tr>
		<tr>
			<td>Norotrode EMG electrodes</td>
			<td>Myotronics</td>
			<td>N/A</td>
			<td>EMG electrodes</td>
		</tr>
		<tr>
			<td>BNC-2111 Single-Ended, Shielded BNC Connector Block</td>
			<td>National Instruments</td>
			<td>779347-01</td>
			<td>BNC Connector Block</td>
		</tr>
		<tr>
			<td>NI PXI-1033 
			5-Slot PXI Chassis with Integrated MXI-Express Controller</td>
			<td>National Instruments</td>
			<td>779757-01</td>
			<td>DAQ chassis</td>
		</tr>
		<tr>
			<td>NI PXI-6254 
			16-Bit, 1 MS/s (Multichannel), 1.25 MS/s (1-Channel), 32 Analog Inputs</td>
			<td>National Instruments</td>
			<td>779118-01</td>
			<td>DAQ card</td>
		</tr>
		<tr>
			<td>SHC68-68-EPM Cable (2m)</td>
			<td>National Instruments</td>
			<td>192061-02</td>
			<td>Shielded cable</td>
		</tr>
		<tr>
			<td>DK1 or DK2</td>
			<td>Oculus VR</td>
			<td>N/A</td>
			<td>Ocuclus Rift headset</td>
		</tr>
		<tr>
			<td>Vizard 5 Lite</td>
			<td>WorldViz</td>
			<td>N/A</td>
			<td>Virtual reality software</td>
		</tr>
		<tr>
			<td>C1 and C2 capacitors</td>
			<td>varied</td>
			<td>N/A</td>
			<td>Adjust values to suit</td>
		</tr>
		<tr>
			<td>R1 and R2 resistors</td>
			<td>varied</td>
			<td>N/A</td>
			<td>Adjust values to suit</td>
		</tr>
		<tr>
			<td>CD4011 NAND gate</td>
			<td>varied</td>
			<td>N/A</td>
			<td>NAND gate</td>
		</tr>
		<tr>
			<td>2N2222 transistor</td>
			<td>varied</td>
			<td>N/A</td>
			<td>Transistor</td>
		</tr>
		<tr>
			<td>NE555 timer circuit</td>
			<td>varied</td>
			<td>N/A</td>
			<td>Timer circuit</td>
		</tr>
		<tr>
			<td>DB25 and USB connectors</td>
			<td>varied</td>
			<td>N/A</td>
			<td>parallel and USB connectors</td>
		</tr>
	</tbody>
</table>

multifunctional setup for studying human motor control using transcranial magnetic stimulation, electromyography, motion capture, and virtual reality

המחקר של שליטה עצבית-שרירית של תנועה בבני האדם נעשה עם מספר רב של טכנולוגיות. שיטות לא פולשניות לחקירת תפקוד עצבית-שרירית כוללות גירוי מגנטי transcranial, electromyography, ולכידת תנועה תלת-ממדית. כניסתו של פתרונות מציאות וירטואלית זמינים וחסכוניים בקלות הרחיבה את היכולות של חוקרים ביצירה מחדש של סביבות ותנועות &quot;בעולם האמיתי&quot; בסביבת מעבדה. ניתוח תנועת נטורליסטי לא רק לגייס הבנה טובה יותר של שליטה מוטורית באנשים בריאים, אלא גם לאפשר העיצוב של ניסויים ואסטרטגיות שיקום כי יעד ליקויים ספציפיים מוטוריים (למשל שבץ). השימוש בשילוב של כלים אלה יוביל להבנה יותר ויותר עמוקה יותר של מנגנונים עצביים של שליטה מוטורית. דרישת מפתח כאשר משלבים מערכות רכישת נתונים אלה היא התכתבות זמנית עדינה בין זרמי נתונים השונים. Tהפרוטוקול שלו מתאר קישוריות של מערכת רב תכליתי הכוללת, איתות intersystem, וסנכרון הזמני של הנתונים שנרשמו. סנכרון של מערכות הרכיב מושגת בעיקר באמצעות השימוש במעגל להתאמה אישית, בקלות שנעשה עם את רכיבי המדף ומיומנויות הרכבה אלקטרוניקה מינימליות.

סנכרון של זרמי נתונים הרבים בהתקנה זו מאפשר להקליט קינמטיקה, פעילות רציפה שריר (EMG), ופעילות עצבית-שרירית (חברי הפרלמנט האירופי) מיידיים המתרחשות במהלך תנועות של הגפיים העליונים. ניסויים חוזרים ונשנים של תנועה נתון נדרשים לשחזר פרופילי תגובה חבר הפרלמנט האירופי על תנ...

Watch this Scientific Journal Video about Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality at JoVE.

Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality

Transcranial magnetic stimulation, electromyography, and 3D motion capture are commonly used non-invasive techniques for investigating neuromuscular function in humans. In this paper, we describe a protocol that synchronously samples data generated by all three of these tools along with the unique addition of virtual reality stimulus presentation and feedback.

הגדרה רב-תכליתית ללימוד אדם בקרת מנוע באמצעות גירוי מגנטי Transcranial, Electromyography, לכידת תנועה, ומציאות וירטואלית

The study of neuromuscular control of movement in humans is accomplished with numerous technologies. Non-invasive methods for investigating neuromuscular ...

multifunctional-setup-for-studying-human-motor-control-using

Research

JoVE Journal

Behavior

10.8K Views.  West Virginia University. Transcranial magnetic stimulation, electromyography, and 3D motion capture are commonly used non-invasive techniques for investigating neuromuscular function in humans. In this paper, we describe a protocol that synchronously samples data generated by all three of these tools along with the unique addition of virtual reality stimulus presentation and feedback.

Video: Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality

Stimulating the Lip Motor Cortex with Transcranial Magnetic Stimulation

Transcranial magnetic stimulation (TMS) has proven to be a useful tool in investigating the role of the articulatory motor cortex in speech perception. Researchers have used single-pulse and repetitive TMS to stimulate the lip representation in the motor cortex. The excitability of the lip motor representation can be investigated by applying single TMS pulses over this cortical area and recording TMS-induced motor evoked potentials (MEPs) via electrodes attached to the lip muscles (electromyography; EMG). Larger MEPs reflect increased cortical excitability. Studies have shown that excitability increases during listening to speech as well as during&#160;viewing speech-related movements. TMS can be used also to disrupt the lip motor representation. A 15-min train of low-frequency sub-threshold repetitive stimulation has been shown to suppress motor excitability for a further 15-20 min. This TMS-induced disruption of the motor lip representation impairs subsequent performance in demanding speech perception tasks and modulates auditory-cortex responses to speech sounds. These findings are consistent with the suggestion that the motor cortex contributes to speech perception. This article describes how to localize the lip representation in the motor cortex and how to define the appropriate stimulation intensity for carrying out both single-pulse and repetitive TMS experiments.

Transcranial magnetic stimulation (TMS) has proven to be a useful tool in investigating the role of the articulatory motor cortex in speech perception.&#160; This article describes how to record motor evoked potentials (MEPs) from the lip muscles and how to disrupt the motor lip representation using repetitive TMS.

מגרה את השפתיים מוטור קורטקס עם גירוי מגנטי Transcranial

Transcranial magnetic stimulation (TMS) has proven to be a useful tool in investigating the role of the articulatory motor cortex in speech perception. ...

Transcranial Direct Current Stimulation and Simultaneous  Functional Magnetic Resonance Imaging

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that uses weak electrical currents administered to the scalp to manipulate cortical excitability and, consequently, behavior and brain function. In the last decade, numerous studies have addressed short-term and long-term effects of tDCS on different measures of behavioral performance during motor and cognitive tasks, both in healthy individuals and in a number of different patient populations. So far, however, little is known about the neural underpinnings of tDCS-action in humans with regard to large-scale brain networks. This issue can be addressed by combining tDCS with functional brain imaging techniques like functional magnetic resonance imaging (fMRI) or electroencephalography (EEG).
In particular, fMRI is the most widely used brain imaging technique to investigate the neural mechanisms underlying cognition and motor functions. Application of tDCS during fMRI allows analysis of the neural mechanisms underlying behavioral tDCS effects with high spatial resolution across the entire brain. Recent studies using this technique identified stimulation induced changes in task-related functional brain activity at the stimulation site&#160;and also in more distant brain regions, which were associated with behavioral improvement. In addition, tDCS administered during resting-state fMRI allowed identification of widespread changes in whole brain functional connectivity.
Future studies using this combined protocol should yield new insights into the mechanisms of tDCS action in health and disease and new options for more targeted application of tDCS in research and clinical settings. The present manuscript describes this novel technique in a step-by-step fashion, with a focus on technical aspects of tDCS administered during fMRI.

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique. It has successfully been used in basic research and clinical settings to modulate brain function in humans. This article describes the implementation of tDCS and simultaneous functional magnetic resonance imaging (fMRI), to investigate the neural basis of tDCS effects.

Transcranial זרם ישר גירוי והדמיית תהודה מגנטית פונקציונלית בו זמנית

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that uses weak electrical currents administered to the scalp ...

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course

Transcranial magnetic stimulation (TMS) is a safe, non-invasive brain stimulation technique that uses a strong electromagnet in order to temporarily disrupt information processing in a brain region, generating a short-lived &#8220;virtual lesion.&#8221; Stimulation that interferes with task performance indicates that the affected brain region is necessary to perform the task normally. In other words, unlike neuroimaging methods such as functional magnetic resonance imaging (fMRI) that indicate correlations between brain and behavior, TMS can be used to demonstrate causal brain-behavior relations. Furthermore, by varying the duration and onset of the virtual lesion, TMS can also reveal the time course of normal processing. As a result, TMS has become an important tool in cognitive neuroscience. Advantages of the technique over lesion-deficit studies include better spatial-temporal precision of the disruption effect, the ability to use participants as their own control subjects, and the accessibility of participants. Limitations include concurrent auditory and somatosensory stimulation that may influence task performance, limited access to structures more than a few centimeters from the surface of the scalp, and the relatively large space of free parameters that need to be optimized in order for the experiment to work. Experimental designs that give careful consideration to appropriate control conditions help to address these concerns. This article illustrates these issues with TMS results that investigate the spatial and temporal contributions of the left supramarginal gyrus (SMG) to reading.

Transcranial magnetic stimulation (TMS) is a technique for non-invasively disrupting neural information processing and measuring its effect on behavior. When TMS interferes with a task, it indicates that the stimulated brain region is necessary for normal task performance, allowing one to systematically relate brain regions to cognitive functions.

גירוי מגנטי Transcranial לחקירת קשרים סיבתיים מוח התנהגותי וכמובן זמנם

Transcranial magnetic stimulation (TMS) is a safe, non-invasive brain stimulation technique that uses a strong electromagnet in order to temporarily ...

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia

Repetitive transcranial magnetic stimulation (rTMS) is widely used for several neurological conditions, as it has gained acknowledgement for its potential therapeutic effects. Brain excitability is non-invasively modulated by rTMS, and rTMS to the language areas has proved its potential effects on treatment of aphasia. In our protocol, we aim to artificially induce virtual aphasia in healthy subjects by inhibiting Brodmann area 44 and 45 using neuronavigational TMS (nTMS), and F3 of the International 10-20 EEG system for conventional TMS (cTMS). To measure the degree of aphasia, changes in reaction time to a picture naming task pre- and post-stimulation are measured and compare the delay in reaction time between nTMS and cTMS. Accuracy of the two TMS stimulation methods is compared by averaging the Talairach coordinates of the target and the actual stimulation. Consistency of stimulation is demonstrated by the error range from the target. The purpose of this study is to demonstrate use of nTMS and to describe the benefits and limitations of the nTMS compared to those of cTMS.

This study is designed to test the hypothesis that neuronavigational system-guided transcranial magnetic stimulation has higher accuracy for targeting the intended target as demonstrated by eliciting a greater degree of virtual aphasia in healthy subjects, measured by delay in reaction time to picture naming.

Neuronavigation מונחה חוזר Transcranial Magnetic Stimulation עבור אפזיה

Repetitive transcranial magnetic stimulation (rTMS) is widely used for several neurological conditions, as it has gained acknowledgement for its potential ...

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil

Repetitive transcranial magnetic stimulation (rTMS) is an emerging non-pharmacological approach to treating many brain-based disorders. rTMS uses electromagnetic coils to stimulate areas of the brain non-invasively. Deep transcranial magnetic stimulation (dTMS) with the Brainsway H1-coil system specifically is a type of rTMS indicated for treating patients with major depressive disorder (MDD) who are resistant to medication. The unique H1-coil design of this device is able to stimulate neuronal pathways that lie deeper in the targeted brain areas than those reached by conventional rTMS coils. dTMS is considered to be low-risk and well tolerated, making it a viable treatment option for people who have not responded to medication or psychotherapy trials for their depression.
Randomized, sham-control studies have demonstrated that dTMS produces significantly greater improvement in depressive symptoms than sham dTMS treatment in patients with major depression that has not responded to antidepressant medication. In this paper, we will review the methodology for treating major depression with dTMS using an H1-coil.

Here we present a protocol outlining the methodology for treatment of Major Depressive Disorder using the deep Transcranial Magnetic Stimulation (dTMS) system.

טיפול דיכאון קליני עם גירוי מגנטי Transcranial העמוק חוזר שימוש סליל H1 בריינסוויי

Repetitive transcranial magnetic stimulation (rTMS) is an emerging non-pharmacological approach to treating many brain-based disorders. rTMS uses ...

Substantiating Appropriate Motion Capture Techniques for the Assessment of Nordic Walking Gait and Posture in Older Adults

Nordic walking (NW) has become a safe and simple form of exercise in recent years, and in studying this gait pattern, various data collection techniques have been employed, each with positives and negatives. The aim was to determine the effect of NW on older adult gait and posture and to determine optimal use of different data collection systems in both short and long duration analysis. Gait and posture during NW and normal walking were assessed in 17 healthy older adults (age: 69 &#177; 7.3). Participants performed two trials of 6 Minute Walk Tests (6MWT) (1 with poles (WP) and 1 without poles (NP)) and 6 trials of a 5m walk (3 WP and 3 NP). Motion was recorded using two systems, a 6-sensor accelerometry system and an 8-camera 3-dimensional motion capture system, in order to quantify spatial-temporal, kinematic, and kinetic parameters.
With both systems, participants demonstrated increased stride length and double support and decreased gait speed and cadence WP compared to NP (p &#60;0.05). Also, with motion capture, larger single support time was found WP (p &#60;0.05). With 3-D capture, smaller hip power generation and moments of force were found at heel contact and pre-swing as well as smaller knee power absorption at heel contact, pre-swing, and terminal swing WP compared to NP, when assessed over one cycle (p &#60;0.05). Also, WP yielded smaller moments of force at heel contact and terminal swing along with larger moments at mid-stance of a gait cycle (p &#60;0.05). No changes were found for posture.
NW seems appropriate for promoting a normal gait pattern in older adults. Three-dimensional motion capture should primarily be used during short duration gait analysis (i.e. single gait cycle), while accelerometry systems should be primarily employed in instances requiring longer duration analysis such as during the 6MWT.

The aim was to substantiate optimal use of data collection techniques for Nordic walking gait and posture analysis. Three-dimensional motion capture should be used during short duration analysis (i.e. single gait cycle), while accelerometry should be employed for longer duration analysis (i.e. repeated cycles) like a 6 Minute Walk Test.

המוכיח טכניקות לכידות תנועה מתאימה לכל ההערכה של הליכה ויציבת הליכה נורדית אצל קשישים

Nordic walking (NW) has become a safe and simple form of exercise in recent years, and in studying this gait pattern, various data collection techniques ...

Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain

Previous rodent models of repetitive transcranial magnetic stimulation (rTMS) adopted whole-brain stimulation instead of unilateral hemispheric rTMS, which is unlike the protocols used for human subjects. We report a successful application of rTMS to the unilateral hemisphere of rat brain. The rTMS was delivered with a low-frequency (1 Hz), high-frequency (20 Hz), or sham stimulation protocol to one side of the brain by using a small 25-mm figure-8 coil. We placed the center of the coil 1 cm lateral to the vertex on the biauricular line and angulated the coil 45&#176; to the ground to minimize a potential direct effect of rTMS on the contralateral cortex. We also used an in-house water cooling system to enable repetitive magnetic stimulation for more than 20 min, even at a 20-Hz stimulation frequency. Increases in the transcriptions of immediate early genes (Arc, Junb, and Egr2) were greater after rTMS than after sham stimulation. After 5 consecutive days of 20-min 1-Hz rTMS, bdnf mRNA expression was significantly higher in stimulated cortex than in contralateral side. The model presented herein will elucidate the molecular mechanisms of rTMS by allowing analysis of the inter-hemispheric difference in its effect.

We applied repetitive transcranial magnetic stimulation (rTMS) to the unilateral hemisphere of rat brain, by placing a 25-mm figure-8 coil 1 cm lateral to the vertex on the biauricular line and angulating the coil by 45&#176;. An in-house water cooling system was used for rTMS for more than 20 min.

גירוי מגנטי Transcranial חוזרים אל חצי הכדור החד-צדדית של המוח עכברוש

Previous rodent models of repetitive transcranial magnetic stimulation (rTMS) adopted whole-brain stimulation instead of unilateral hemispheric rTMS, ...

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Transcranial alternating current stimulation (tACS) is a promising tool for noninvasive investigation of brain oscillations. TACS employs frequency-specific stimulation of the human brain through current applied to the scalp with surface electrodes. Most current knowledge of the technique is based on behavioral studies; thus, combining the method with brain imaging holds potential to better understand the mechanisms of tACS. Because of electrical and susceptibility artifacts, combining tACS with brain imaging can be challenging, however, one brain imaging technique that is well suited to be applied simultaneously with tACS is functional magnetic resonance imaging (fMRI). In our lab, we have successfully combined tACS with simultaneous fMRI measurements to show that tACS effects are state, current, and frequency dependent, and that modulation of brain activity is not limited to the area directly below the electrodes. This article describes a safe and reliable setup for applying tACS simultaneously with visual task fMRI studies, which can lend to understanding oscillatory brain function as well as the effects of tACS on the brain.

Transcranial alternating current stimulation (tACS) is a promising tool for noninvasive investigation of brain oscillations, though its effects are not completely understood. This article describes a safe and reliable setup for applying tACS simultaneously with functional magnetic resonance imaging, which can increase understanding oscillatory brain function and effects of tACS.

סימולטני transcranial גירוי הזרם הנוכחי ו הדמיה תפקודית תהודה מגנטית

Transcranial alternating current stimulation (tACS) is a promising tool for noninvasive investigation of brain oscillations. TACS employs ...

Using Virtual Reality to Transfer Motor Skill Knowledge from One Hand to Another

As far as acquiring motor skills is concerned, training by voluntary physical movement is superior to all other forms of training (e.g. training by observation or passive movement of trainee&#39;s hands by a robotic device). This obviously presents a major challenge in the rehabilitation of a paretic limb since voluntary control of physical movement is limited. Here, we describe a novel training scheme we have developed that has the potential to circumvent this major challenge. We exploited the voluntary control of one hand and provided real-time movement-based manipulated sensory feedback as if the other hand is moving. Visual manipulation through virtual reality (VR) was combined with a device that yokes left-hand fingers to passively follow right-hand voluntary finger movements. In healthy subjects, we demonstrate enhanced within-session performance gains of a limb in the absence of voluntary physical training. Results in healthy subjects suggest that training with the unique VR setup might also be beneficial for patients with upper limb hemiparesis by exploiting the voluntary control of their healthy hand to improve rehabilitation of their affected hand.

We describe a novel virtual-reality based setup which exploits voluntary control of one hand to improve motor-skill performance in the other (non-trained) hand. This is achieved by providing real-time movement-based sensory feedback as if the non-trained hand is moving. This new approach may be used to enhance rehabilitation of patients with unilateral hemiparesis.

באמצעות מציאות מדומה כדי להעביר יכולות מוטוריות ידע מיד אחת לאחרת

As far as acquiring motor skills is concerned, training by voluntary physical movement is superior to all other forms of training (e.g. training by ...

Measuring the Kinematics of Daily Living Movements with Motion Capture Systems in Virtual Reality

The inability to complete instrumental activities of daily living (IADL) is a precursor to various neuropsychological diseases. Questionnaire-based assessments of IADL are easy to use but prone to subjective bias. Here, we describe a novel virtual reality (VR) test to assess two complex IADL tasks: handling financial transactions and using public transportation. While a participant performs the tasks in a VR setting, a motion capture system traces the position and orientation of the dominant hand and head in a three-dimensional Cartesian coordinate system. Kinematic raw data are collected and converted into &#39;kinematic performance measures,&#39; i.e., motion trajectory, moving distance, and time to completion. Motion trajectory is the path of a particular body part (e.g., dominant hand or head) in space. Moving distance refers to the total distance of the trajectory, and time to completion is how long it took to complete an IADL task. These kinematic measures could discriminate patients with cognitive impairment from healthy controls. The development of this kinematic measuring protocol allows detection of early IADL-related cognitive impairments.

We designed a virtual reality test to assess instrumental activities of daily living (IADL) with a motion capture system. We propose a detailed kinematic analysis to interpret the participant&#39;s various movements, including trajectory, moving distance, and time to completion to evaluate IADL capabilities.

מדידה קינמטיקה של תנועות החיים יומי עם מערכות לכידת תנועה במציאות וירטואלית

The inability to complete instrumental activities of daily living (IADL) is a precursor to various neuropsychological diseases. Questionnaire-based ...