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University of Technology Sydney (UTS)

3 ARTICLES PUBLISHED IN JoVE

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Chemistry

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
Morgan Philp 1, Ronald Shimmon 1, Mark Tahtouh 2, Shanlin Fu 1
1Centre for Forensic Science, University of Technology Sydney (UTS), 2Australian Federal Police (AFP)

Here we present a simple, inexpensive, and selective chemical spot test protocol for the detection of synthetic cathinones, a class of new psychoactive substances. The protocol is suitable for use in various areas of law enforcement that encounter illicit material.

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Bioengineering

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction
Christopher D. Roche 1,2,3,4, Carmine Gentile 1,2,3
1The University of Sydney, 2University of Technology Sydney (UTS), 3The Royal North Shore Hospital, 4University Hospital of Wales

This protocol aims to transplant a 3D bioprinted patch onto the epicardium of infarcted mice modeling heart failure. It includes details regarding anesthesia, the surgical chest opening, permanent ligation of the left anterior descending (LAD) coronary artery and application of a bioprinted patch onto the infarcted area of the heart.

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Bioengineering

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology
Poonam Sharma 1,2,3,4, Carmine Gentile 2,3,4
1University of Newcastle, 2University of Sydney, 3Kolling Institute of Medical Research, Royal North Shore Hospital, 4University of Technology, Sydney

This protocol aims to fabricate 3D cardiac spheroids (CSs) by co-culturing cells in hanging drops. Collagen-embedded CSs are treated with doxorubicin (DOX, a cardiotoxic agent) at physiological concentrations to model heart failure. In vitro testing using DOX-treated CSs may be used to identify novel therapies for heart failure patients.

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