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Inner Mongolia Medical University

6 ARTICLES PUBLISHED IN JoVE

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Biology

Chitosan/Interfering RNA Nanoparticle Mediated Gene Silencing in Disease Vector Mosquito Larvae
Xin Zhang *1, Keshava Mysore *2,3, Ellen Flannery 3,4, Kristin Michel 1, David W. Severson 3,4, Kun Yan Zhu 5, Molly Duman-Scheel 2,3,4
1Division of Biology, Kansas State University, 2Department of Medical and Molecular Genetics, Indiana University School of Medicine, 3Eck Institute for Global Health, University of Notre Dame, 4Department of Biological Sciences, University of Notre Dame, 5Department of Entomology, Kansas State University

Here we describe a procedure for inhibiting gene function in disease vector mosquitoes through the use of chitosan/interfering RNA nanoparticles that are ingested by larvae.

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Cancer Research

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Ravan Moret 1, Linh Hellmers 1, Xin Zhang 1, Jessie Gills 2, Nathan Hite 3, Aaron Klinger 3, Grace A. Maresh 1, Daniel Canter 2,4, Stephen Bardot 2,4, David A Margolin 3,4, Li Li 1,4
1Laboratory of Translational Cancer Research, Institute for Translational Research, Ochsner Clinic Foundation, 2Department of Urology, Ochsner Clinic Foundation, 3Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, 4Ochsner Clinical School, University of Queensland, School of Medicine

This protocol describes the generation of patient-derived orthotopic xenograft models by intra-vesically instilling high-grade urothelial cell carcinoma cells or intra-rectally injecting colorectal cancer cells into non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice for primary tumor growth and spontaneous metastases under the influence of lymph node stromal cells, which mimics the progression of human metastatic diseases.

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Behavior

Physical Activity Measurement in Children Accepting Table Tennis Training
Xin Zhang *1, Cuiqiao Xia *2, Xiuli Zhao 3, Yu Liu 3, Hóngyi Zhào 2,3, Yonghua Huang 2
1Department of Sport, Inner Mongolia Medical University, 2Department of Neurology, The Seventh Medical Center of PLA General Hospital, 3Department of Neurology, NO 984 Hospital of PLA

This study proposes an accelerometer-based method to objectively measure physical activity (PA) and leisure time physical activity (LTPA) in Chinese children accepting table tennis training in clubs.

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Medicine

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
Riga Wu *1, Wen Zu *1, Lisi Wu 1, Si Su 1, Nier Su 1, Ligeer Qi 1, Rilaga Wu 1, Wei Sun 2, Rilebagen Hu 1
1Faculty of Mongolian Medicine, Inner Mongolia Medical University, 2Affiliated Hospital of Inner Mongolia Medical University

The present protocol describes a method for the behavioral test validation and bioinformatical prediction of the therapeutic efficacy of Zadi-5, a traditional Mongolian medicine, in depression.

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Medicine

Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine
Hongmei Xin *1, Si Su *2, Riga Wu 2, Lisi Wei 2, Nier Su 2, Ligeer Qi 2, Rilaga Wu 2, Ruhan A 2, Lijun Tong 2, Wuji Wang 3, Jing Zhang 3, Rilebagen Hu 2, Li Li 3
1Faculty of Humanities Education, Inner Mongolia Medical University, 2Faculty of Mongolian Medicine, Inner Mongolia Medical University, 3Faculty of Basic Medical, Inner Mongolia Medical University

This protocol outlines a chronic unpredictable mild stress (CUMS) model for depression based on Mongolian medical theory, along with methods for validating behavioral tests.

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Biology

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
Qinglan Bao 1, Xiaoxiao Zhang 2, Yingsong Chen *1,3,4, Tegexibaiyin Wang *5, Bateer Siqin *6
1Inner Mongolia Medical University, 2Xilin Gol League Mongolian Medical Hospital, 3National and local Joint Mongolian Medicine R & D Engineering Center, 4Inner Mongolia Minzu University, 5Affiliated Hospital of Inner Mongolia Minzu University, 6Traditional Chinese & Mongolian Medical Research Institute of Inner Mongolia

This article describes the use of oleic acid-induced HepG2 cells as a model for metabolic dysfunction-associated steatotic liver disease.

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