Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
10.1K Views
•
09:28 min
•
May 12th, 2019
DOI :
May 12th, 2019
•Ravan Moret1, Linh Hellmers1, Xin Zhang1, Jessie Gills2, Nathan Hite3, Aaron Klinger3, Grace A. Maresh1, Daniel Canter2,4, Stephen Bardot2,4, David A Margolin3,4, Li Li1,4
1Laboratory of Translational Cancer Research, Institute for Translational Research, Ochsner Clinic Foundation, 2Department of Urology, Ochsner Clinic Foundation, 3Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, 4Ochsner Clinical School, University of Queensland, School of Medicine
Chapters in this video
0:04
Title
0:55
Tumor Enzymatic Digestion
2:54
UCC Mouse Model
4:48
CRC Mouse Model
6:02
Bioluminescent Imaging, Organ Harvesting and Evaluation
6:55
Results: Xenograft Tumor Analysis and Comparison with Primary Patient Tumors
8:44
Conclusion
Related Videos
09:16
High-sensitivity Detection of Micrometastases Generated by GFP Lentivirus-transduced Organoids Cultured from a Patient-derived Colon Tumor
10.0K Views
07:50
Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts
8.3K Views
04:02
Generation of a Liver Orthotopic Human Uveal Melanoma Xenograft Platform in Immunodeficient Mice
8.6K Views
07:48
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
12.5K Views
06:48
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
35.1K Views
08:15
Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
15.9K Views
06:49
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
1.8K Views
07:01
Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
14.3K Views
01:37
Patient-derived Tumor Xenografting: A Technique to Generate Experimental Mouse Model for Evaluating Urothelial Cell Carcinoma
1.2K Views
02:57
Spontaneous Metastasis Mouse Models: A Platform to Study the Metastatic Potential of Orthotopically Injected Colorectal Cancer Cells
1.3K Views
Copyright © 2025 MyJoVE Corporation. All rights reserved