St Vincent's Institute of Medical Research

1 ARTICLES PUBLISHED IN JoVE

Bioengineering

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Weiqing Zhan^*1, Diego Marre^*1, Geraldine M. Mitchell^1,2,3, Wayne A. Morrison^1,2,3, Shiang Y. Lim^1,2

¹O'Brien Institute Department, St Vincent's Institute of Medical Research, ²Department of Surgery, University of Melbourne, ³Faculty of Health Sciences, Australia Catholic University

This is a guideline for constructing in vivo vascularized tissue using a microsurgical arteriovenous loop or a flow-through pedicle configuration inside a tissue engineering chamber. The vascularized tissues generated can be employed for organ regeneration and replacement of tissue defects, as well as for drug testing and disease modeling.