Thomas Jefferson University

2 ARTICLES PUBLISHED IN JoVE

Medicine

Non-invasive Assessment of Microvascular and Endothelial Function

Cynthia Cheng¹, Constantine Daskalakis², Bonita Falkner³

¹Department of Family and Community Medicine, Thomas Jefferson University , ²Department of Pharmacology and Experimental Therapeutics, Biostatistics Division, Thomas Jefferson University, ³Department of Internal Medicine, Thomas Jefferson University

Capillaroscopy is a non-invasive, relatively inexpensive methodology for directly visualizing the microcirculation. The forearm blood flow technique provides accepted non-invasive measures of endothelial function.

Medicine

A Reproducible Computerized Method for Quantitation of Capillary Density using Nailfold Capillaroscopy

Cynthia Cheng^*1, Chadd W. Lee^*2, Constantine Daskalakis³

¹Department of Family and Community Medicine, Thomas Jefferson University, ²Sidney Kimmel Medical College, Thomas Jefferson University, ³Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University

Capillaroscopy is a non-invasive, efficient, relatively inexpensive and easy-to-learn methodology for directly visualizing capillaries in the microcirculation. However, only one publication to date describes the reliability of a complex software program available for quantitating capillaroscopy data. Here, we present a simple, reliable protocol for quantitating capillaries using a standardized algorithm.