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University of Southern California (USC)

3 ARTICLES PUBLISHED IN JoVE

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Medicine

Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Marie-Victoire Guillot-Sestier 1, Tara M. Weitz 1, Terrence Town 1
1Zilkha Neurogenetic Institute, University of Southern California (USC)

We developed a methodology for quantitative 3D in silico modeling (q3DISM) of cerebral amyloid-β (Aβ) phagocytosis by mononuclear phagocytes in rodent models of Alzheimer's disease. This method can be generalized for the quantitation of virtually any phagocytic event in vivo.

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Bioengineering

Dissection, MicroCT Scanning and Morphometric Analyses of the Baculum
Nicholas G. Schultz 1, Erik Otárola-Castillo 2, Matthew D. Dean 1
1Molecular and Computational Biology, University of Southern California (USC), 2Purdue University

Many biological structures lack easily definable landmarks, making it difficult to apply modern morphometric methods. Here we illustrate methods to study the mouse baculum (a bone in the penis), including dissection and microCT scanning, followed by computational methods to define semi-landmarks that are used to quantify size and shape variation.

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Biology

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques
Colleen M. Garvey 1, Torin A. Gerhart 1, Shannon M. Mumenthaler 1
1Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California (USC)

We have developed a novel protocol for studying heterocellular population dynamics in response to perturbations. This manuscript describes an imaging-based platform that produces quantitative datasets for simultaneous characterization of multiple cellular phenotypes of heterocellular populations in a robust manner.

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