Tokyo Animal Eye Clinic

1 ARTICLES PUBLISHED IN JoVE

Medicine

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion

Deokho Lee^*1,2, Yukihiro Miwa^*1,2,3, Heonuk Jeong^1,2, Shin-ichi Ikeda^1,2, Yusaku Katada^1,2, Kazuo Tsubota^1,2,4, Toshihide Kurihara^1,2

¹Laboratory of Photobiology, Keio University School of Medicine, ²Department of Ophthalmology, Keio University School of Medicine, ³Animal eye care, Tokyo Animal Eye Clinic, ⁴Tsubota Laboratory, Inc.

Here, we describe a mouse model of retinal ischemia by transient bilateral common carotid artery occlusion using simple sutures and a clamp. This model can be useful for understanding the pathological mechanisms of retinal ischemia caused by cardiovascular abnormalities.