BCRT (BIH Center of Regenerative Therapies)

2 ARTICLES PUBLISHED IN JoVE

Medicine

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Xiaolin Sun^*1,2, Yimeng Hao^*1,2, Jonathan Frederik Sebastian Kiekenap¹, Jasper Emeis¹, Marvin Steitz², Alexander Breitenstein-Attach², Felix Berger^1,2, Boris Schmitt^1,2,3

¹Department of Pediatric Cardiology and Congenital Heart Disease, Charité University Medicine Berlin, ²Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Berlin, ³DZHK (German Centre for Cardiovascular Research) and BMBF (German Ministry of Education and Research)

This study assessed a new methodology with a straightened model generated from the four-dimensional cardiac computed tomography sequence to obtain the desired measurements for valve sizing in the application of transcatheter pulmonary valve replacement.

Medicine

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Yimeng Hao^1,2, Xiaolin Sun^1,2, Jonathan Frederik Sebastian Kiekenap¹, Jasper Emeis¹, Marvin Steitz², Alexander Breitenstein-Attach², Felix Berger^1,2, Boris Schmitt^1,2,3,4,5

This study demonstrates the feasibility and safety of developing an autologous pulmonary valve for implantation at the native pulmonary valve position by using a self-expandable Nitinol stent in an adult sheep model. This is a step toward developing transcatheter pulmonary valve replacement for patients with right ventricular outflow tract dysfunction.