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IEO, European Institute of Oncology IRCCS

3 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Giulia Ercoli 1, Gianluca Lopez 1,2, Camilla Ciapponi 1,3, Chiara Corti 1,2, Luca Despini 4, Donatella Gambini 5, Letterio Runza 1, Concetta Blundo 4, Amedeo Sciarra 1, Nicola Fusco 1,6
1Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 2School of Medicine, University of Milan, 3School of Biology, University of Pavia, 4Division of Breast Surgery, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, 5Division of Medical Oncology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, 6Department of Biomedical, Surgical, and Dental Sciences, University of Milan

Heterogeneous distribution of HER2-positive cells can be observed in a subset of breast cancers and generates clinical dilemmas. Here, we introduce a reliable and cost-effective protocol to define, quantify, and compare HER2 intra-tumor genetic heterogeneity in a large series of heterogeneously processed breast cancers.

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Medicine

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
Marco Invernizzi 1, Letterio Runza 2, Alessandro De Sire 1, Lorenzo Lippi 1, Concetta Blundo 3, Donatella Gambini 4, Renzo Boldorini 5,6, Stefano Ferrero 2,7, Nicola Fusco 2,7
1Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", 2Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 3Division of Breast Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 4Division of Medical Oncology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 5Division of Pathology, Maggiore della Carità Hospital, 6Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", 7Department of Biomedical, Surgical, and Dental Sciences, University of Milan

Breast cancer related lymphedema is frequent in breast cancer survivors, but there are not widely employed guidelines for its diagnosis and quantification. Here, we introduce a reliable and cost-effective protocol to define, quantify, and compare upper limb volume in breast cancer patients.

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Cancer Research

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
Giuseppina Bonizzi *1, Maria Capra *1, Cristina Cassi 1, Giulio Taliento 1, Oriana Pala 2, Elham Sajjadi 2,3, Konstantinos Venetis 2,3, Mariia Ivanova 2, Massimo Monturano 4, Giuseppe Renne 2, Lorenzo Zattoni 1,3, Elena Guerini-Rocco 2,3, Giuseppe Viale 2,3, Roberto Orecchia 5, Nicola Fusco 1,2,3
1Biobank for Translational and Digital Medicine Unit, IEO, European Institute of Oncology IRCCS, 2Division of Pathology, IEO, European Institute of Oncology IRCCS, 3Department of Oncology and Hemato-Oncology, University of Milan, 4Patient Safety & Risk Management Service, IEO, European Institute of Oncology IRCCS, 5Scientific Directorate, IEO, European Institute of Oncology IRCCS

Biobanks are crucial resources for biomedical research and the Biobank for Translational and Digital Medicine Unit at the European Institute of Oncology is a model in this field. Here, we provide a detailed description of biobanks' standard operating procedures for the management of different types of human biological samples.

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