Nicholas R. Lemoine

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif.

Use of DNA fingerprinting to detect genetic rearrangements in human cancer.

Sex chromosome anomalies in pancreatic endocrine tumors.

Dpc4 is expressed in virtually all primary and metastatic pancreatic endocrine carcinomas.

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.

Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas.

Expression profiling of microdissected pancreatic adenocarcinomas.

Adenovirus biodistribution and noninvasive imaging of gene expression in vivo by positron emission tomography using human sodium/iodide symporter as reporter gene.

DNA fingerprinting from cells captured by laser microdissection.

Recombinant E. coli efficiently delivers antigen and maturation signals to human dendritic cells: presentation of MART1 to CD8+ T cells.

Sodium iodide symporter: a new strategy to target cancer?

Procaspase 3 expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant-negative mutant, survivin T34A; a combination gene therapy strategy.

Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer.

Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent.

Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells.

Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma.

Clinical trials with GDEPT: cytosine deaminase and 5-fluorocytosine.

Role of Bim in the survival pathway induced by Raf in epithelial cells.

Quantitative imaging of Na/I symporter transgene expression using positron emission tomography in the living animal.

A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu oncogene.

Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS).

Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite.

Noninvasive imaging of the transcriptional activities of human telomerase promoter fragments in mice.

Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis.

Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor.

Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene.

Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway.

Antithrombotic therapy in cancer.

Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer.

Peanut-like 1 (septin 5) gene expression in normal and neoplastic human endocrine pancreas.

Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation.

Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma.

Analysis of p53 mutations for a mutational signature in human intrahepatic cholangiocarcinoma.

Quantifying the activity of adenoviral E1A CR2 deletion mutants using renilla luciferase bioluminescence and 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography imaging.

The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells.

Cytotoxic action of phorbol esters on human pancreatic cancer cells.

S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer.

The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D.

Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets.

Biological approaches to therapy of pancreatic cancer.

Therapeutic potential of replication-selective oncolytic adenoviruses on cells from familial and sporadic desmoid tumors.

Genome-wide analysis of pancreatic cancer using microarray-based techniques.

SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms.

AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001.

A web-based platform for mining pancreatic expression datasets.

Pancreatic cancer: molecular pathogenesis and new therapeutic targets.

Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer.

Online resources of cancer data: barriers, benefits and lessons.

Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts.

Oncolytic Viruses for Cancer Therapy: Overcoming the Obstacles.

Novel therapies for pancreatic cancer: setbacks and progress.

The Pancreatic Expression database: 2011 update.

Analysis of the urine proteome in patients with pancreatic ductal adenocarcinoma.

Using BioMart as a framework to manage and query pancreatic cancer data.

A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws.

AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.

Modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11.

Systemic delivery of oncolytic viruses: hopes and hurdles.

SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update).

O-miner: an integrative platform for automated analysis and mining of -omics data.

S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells.

A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity.

Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway.

Molecular analysis of precursor lesions in familial pancreatic cancer.

A practical guide for the functional annotation of genetic variations using SNPnexus.

The pancreatic expression database: recent extensions and updates.

Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging.

STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus.

Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion.

A vaccinia virus armed with interleukin-10 is a promising therapeutic agent for treatment of murine pancreatic cancer.

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.

New role of Interleukin-10 in enhancing the antitumor efficacy of oncolytic vaccinia virus for treatment of pancreatic cancer.

Vaccinia virus, a promising new therapeutic agent for pancreatic cancer.

Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma.