Lester & Sue Smith Breast Center,
Department of Medicine
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Keratin 6 is not essential for mammary gland development.
Breast cancer research : BCR , 2006 | Pubmed ID: 16790075
Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors.
Neoplasia (New York, N.Y.) Jul, 2008 | Pubmed ID: 18592025
Lentivirus vectors for stably introducing genes into mammary epithelial cells in vivo.
Journal of mammary gland biology and neoplasia Dec, 2009 | Pubmed ID: 19936990
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 20133707
Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer.
Oncogene Oct, 2011 | Pubmed ID: 21532625
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Molecular cell Dec, 2012 | Pubmed ID: 23123196
A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells.
Cell research Mar, 2013 | Pubmed ID: 23266888
Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells.
The Journal of biological chemistry Jul, 2013 | Pubmed ID: 23678002
Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells.
The Journal of pathology Jan, 2014 | Pubmed ID: 24122835
Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis.
PloS one , 2013 | Pubmed ID: 24265712
Wnt-responsive cancer stem cells are located close to distorted blood vessels and not in hypoxic regions in a p53-null mouse model of human breast cancer.
Stem cells translational medicine Jul, 2014 | Pubmed ID: 24797826
STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer.
Stem cells (Dayton, Ohio) Oct, 2014 | Pubmed ID: 24891218
Krt6a-positive mammary epithelial progenitors are not at increased vulnerability to tumorigenesis initiated by ErbB2.
PloS one , 2015 | Pubmed ID: 25635772
Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress.
Oncogene Mar, 2016 | Pubmed ID: 26096929
Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.
Cell reports Jul, 2015 | Pubmed ID: 26166574
Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype.
International journal of biological sciences , 2016 | Pubmed ID: 27019623
Breast tumor cell-specific knockout of inhibits cancer cell plasticity, dissemination, and lung metastasis in mice.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2017 | Pubmed ID: 29073077
Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.
The Journal of clinical investigation 04, 2018 | Pubmed ID: 29480818
Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes.
Cancer research 01, 2019 | Pubmed ID: 30401712
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms.
Nature cell biology 09, 2019 | Pubmed ID: 31451770
Intraductal Injection of Lentivirus Vectors for Stably Introducing Genes into Rat Mammary Epithelial Cells in Vivo.
Journal of mammary gland biology and neoplasia Dec, 2020 | Pubmed ID: 33165800
Targeting the Pro-survival Protein BCL-2 to Prevent Breast Cancer.
Cancer prevention research (Philadelphia, Pa.) Jan, 2022 | Pubmed ID: 34667127
High-throughput profiling of histone post-translational modifications and chromatin modifying proteins by reverse phase protein array.
Journal of proteomics Jun, 2022 | Pubmed ID: 35489683
Short-term PI3K Inhibition Prevents Breast Cancer in Preclinical Models.
Cancer prevention research (Philadelphia, Pa.) Feb, 2023 | Pubmed ID: 36343340