Ralph DaCosta

New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesions.

Molecular fluorescence excitation-emission matrices relevant to tissue spectroscopy.

Autofluorescence-based detection of early neoplasia in patients with Barrett's esophagus.

The potential of autofluorescence for the detection of single living cells for label-free cell sorting in microfluidic systems.

Optical techniques for the endoscopic detection of dysplastic colonic lesions.

Spectroscopy and fluorescence in esophageal diseases.

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals.

Fluorescence and spectral imaging.

Porphyrin-cross-linked hydrogel for fluorescence-guided monitoring and surgical resection.

Directed differentiation of skin-derived precursors into functional vascular smooth muscle cells.

Aberrant axial mineralization precedes spinal ankylosis: a molecular imaging study in ank/ank mice.

Estimation of minimum doses for optimized quantum dot contrast-enhanced vascular imaging in vivo.

Quantifying tissue microvasculature with speckle variance optical coherence tomography.

In vivo optical imaging of tumor and microvascular response to ionizing radiation.

Displaying 3D radiation dose on endoscopic video for therapeutic assessment and surgical guidance.

A novel solid lipid nanoparticle formulation for active targeting to tumor α(v) β(3) integrin receptors reveals cyclic RGD as a double-edged sword.

Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells.

A spinal cord window chamber model for in vivo longitudinal multimodal optical and acoustic imaging in a murine model.

Texture analysis of optical coherence tomography speckle for characterizing biological tissues in vivo.

Tumor vascularization is critical for oncolytic vaccinia virus treatment of peritoneal carcinomatosis.

Advanced imaging technologies for the detection of dysplasia and early cancer in barrett esophagus.

Multifunctional albumin-MnO₂ nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response.

Autofluorescence imaging device for real-time detection and tracking of pathogenic bacteria in a mouse skin wound model: preclinical feasibility studies.

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood-Brain Barrier Targeting Brain Metastases of Breast Cancer.

Dual in vivo photoacoustic and fluorescence imaging of HER2 expression in breast tumors for diagnosis, margin assessment, and surgical guidance.

Point-of-care autofluorescence imaging for real-time sampling and treatment guidance of bioburden in chronic wounds: first-in-human results.

A prototype hand-held tri-modal instrument for in vivo ultrasound, photoacoustic, and fluorescence imaging.

Handheld fluorescence imaging device detects subclinical wound infection in an asymptomatic patient with chronic diabetic foot ulcer: a case report.

Optically-tracked handheld fluorescence imaging platform for monitoring skin response in the management of soft tissue sarcoma.

Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology.

Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging.