Timothy Billiar

The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock.

Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells.

TRISS unexpected survivors: an outdated standard?

A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock.

IFN-gamma inhibition of TRAIL-induced IAP-2 upregulation, a possible mechanism of IFN-gamma-enhanced TRAIL-induced apoptosis.

Role of galectin-3 in breast cancer metastasis: involvement of nitric oxide.

Inducible nitric oxide synthase: from cloning to therapeutic applications.

Requirements for NF-kappaB activation in hemorrhagic shock.

Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis.

Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide.

Mechanisms of hepatoprotection by nitric oxide.

Peroxisomal localization of inducible nitric oxide synthase in hepatocytes.

Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli.

A brief episode of hypotension increases mortality in critically ill trauma patients.

Nitric oxide and wound repair: role of cytokines?

Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization.

A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion.

Maternity policy and practice during surgery residency: how we do it.

Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury.

Characterization of the expression of inducible nitric oxide synthase in rat and human liver during hemorrhagic shock.

Ultraviolet irradiation increases FADD protein in apoptotic human keratinocytes.

Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy.

Regulation of tissue factor expression in smooth muscle cells with nitric oxide.

Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism.

Heme oxygenase-1: a cellular Hercules.

Autologous nitric oxide protects mouse and human keratinocytes from ultraviolet B radiation-induced apoptosis.

There's NO business like p53 business: nitric oxide regulates phosphorylation of p53 in chronic inflammatory disease.

Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation.

Nitric oxide and wound repair.

Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells.

RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression.

Nitric oxide-mediated inhibition of caspase-dependent T lymphocyte proliferation.

A role for angiotensin II in the activation of extracellular signal-regulated kinases in the liver during hemorrhagic shock.

Role of nitric oxide in liver injury.

Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1.

Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility.

Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway.

Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock.

IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo.

Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments.

Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity.

'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity.

The Department of Surgery at the School of Medicine at the University Of Pittsburgh, Pittsburgh, Pa.

Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation.

Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells.

The secretable form of trimeric TRAIL, a potent inducer of apoptosis.

Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of IkappaB.

Tissue hypoxia activates JNK in the liver during hemorrhagic shock.

IFN-gamma enhances TRAIL-induced apoptosis through IRF-1.

Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53.

Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies.

Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both.

Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS.

Application of genome-wide expression analysis to human health and disease.

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion.

Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress.

Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions.

Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation.

The acute inflammatory response in diverse shock states.

The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock.

Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury.

Glutathione depletion renders rat hepatocytes sensitive to nitric oxide donor-mediated toxicity.

Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation.

Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols.

Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells.

Nitric oxide: a clinical primer.

Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier.

Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock.

Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway.

Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4.

The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock.

Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury.

Leukocyte-derived inducible nitric oxide synthase mediates murine postoperative ileus.

Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts.

Carbon monoxide reverses established pulmonary hypertension.

In silico models of acute inflammation in animals.

Ischemic preconditioning of the murine liver protects through the Akt kinase pathway.

Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock.

In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice.

Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage.

Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury.

The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis.

Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock.

Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species.

Targeting CD47: NO limit on therapeutic potential.

Making progress in an enlightened era: opportunities and obstacles.

Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.

A novel inhibitory peptide of Toll-like receptor signaling limits lipopolysaccharide-induced production of inflammatory mediators and enhances survival in mice.

Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling.

Masquerader: high mobility group box-1 and cancer.

Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS.

Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes.

Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols.

Systemic inflammation and remote organ injury following trauma require HMGB1.

Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells.

Increased interactive format for Morbidity & Mortality conference improves educational value and enhances confidence.

The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity.

HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling.

FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells.

Early events in the recognition of danger signals after tissue injury.

Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion.

Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction.

Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes.

Protective effect of p53 in vascular smooth muscle cells against nitric oxide-induced apoptosis is mediated by up-regulation of heme oxygenase-2.

Male gender is associated with excessive IL-6 expression following severe injury.

Application of heme oxygenase-1, carbon monoxide and biliverdin for the prevention of intestinal ischemia/reperfusion injury.

HMGB1: endogenous danger signaling.

Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury.

Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes.

Computational insights on the competing effects of nitric oxide in regulating apoptosis.

Changes in FADD levels, distribution, and phosphorylation in TNFalpha-induced apoptosis in hepatocytes is caspase-3, caspase-8 and BID dependent.

Detection and measurement for the modification and inactivation of caspase by nitrosative stress in vitro and in vivo.

Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture.

The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture.

Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance.

Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes.

Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages.

Parenteral calcium for intensive care unit patients.

An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion.

Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock.

Studies toward the analysis of S-nitrosoproteins.

Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress.

Therapeutic antioxidant medical gas.

Possible novel therapy for malignant gliomas with secretable trimeric TRAIL.

Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism.

Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart.

Innate immune mechanisms in ischemia/reperfusion.

Low-dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality.

Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury.

Preactivation of NKT cells with alpha-GalCer protects against hepatic ischemia-reperfusion injury in mouse by a mechanism involving IL-13 and adenosine A2A receptor.

Activation of latent transforming growth factor-beta1 by nitric oxide in macrophages: role of soluble guanylate cyclase and MAP kinases.

Orally administered nitrite attenuates cardiac allograft rejection in rats.

Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome.

Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis.

The nitric oxide donor S-nitrosoglutathione reduces apoptotic primary liver cell loss in a three-dimensional perfusion bioreactor culture model developed for liver support.

Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells.

Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2.

Oral hydrogen water prevents chronic allograft nephropathy in rats.

Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells.

An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage.

Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both.

Linking oxidative stress to inflammation: Toll-like receptors.

Pivotal advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms.

Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase.

Analysis of factorial time-course microarrays with application to a clinical study of burn injury.

Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus.

Delay to therapeutic interventional radiology postinjury: time is of the essence.

Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and parenchymal cells.

Hepatocytes express functional NOD1 and NOD2 receptors: a role for NOD1 in hepatocyte CC and CXC chemokine production.

A critical role for IFN regulatory factor 1 in NKT cell-mediated liver injury induced by alpha-galactosylceramide.

Superior myocardial preservation with HTK solution over Celsior in rat hearts with prolonged cold ischemia.

Toll-like receptors and myocardial ischemia/reperfusion, inflammation, and injury.

Role of hemorrhage in the induction of systemic inflammation and remote organ damage: analysis of combined pseudo-fracture and hemorrhagic shock.

Complement factor 3 deficiency attenuates hemorrhagic shock-related hepatic injury and systemic inflammatory response syndrome.

Incidental radiographic findings after injury: dedicated attention results in improved capture, documentation, and management.

Toll-like receptors in hepatic ischemia/reperfusion and transplantation.

Differential regulation by fucoidan of IFN-γ-induced NO production in glial cells and macrophages.

Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight.

Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts.

Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury.

High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity.

Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats.

TNF/TNF receptor 1-mediated apoptosis in hepatocytes.

Hydrogen inhalation ameliorates ventilator-induced lung injury.

DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma.

Models of lower extremity damage in mice: time course of organ damage and immune response.

Over reliance on computed tomography imaging in patients with severe abdominal injury: is the delay worth the risk?

Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury.

Histidine-tryptophan-ketoglutarate or celsior: which is more suitable for cold preservation for cardiac grafts from older donors?

Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation.

Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1α in mouse hepatocytes.

A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks.

High-mobility group box 1 is essential for mitochondrial quality control.

Caspase-1 is hepatoprotective during trauma and hemorrhagic shock by reducing liver injury and inflammation.

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice.

Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-α-treated hepatocytes.

Toll-like receptor signaling in liver diseases.

Sepsis: Something old, something new, and a systems view.

The effect of donor treatment with hydrogen on lung allograft function in rats.

Early lower extremity fracture fixation and the risk of early pulmonary embolus: filter before fixation?

Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis.

Mast cells play a critical role in the systemic inflammatory response and end-organ injury resulting from trauma.

Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells.

Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation.

Assessment of platelet transfusion for reversal of aspirin after traumatic brain injury.

Interferon Regulatory Factor-1 Regulates the Autophagic Response in LPS Stimulated Macrophages through Nitric Oxide.

A genomic storm in critically injured humans.

Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice.

Splenocyte Apoptosis and Autophagy is Mediated by Interferon Regulatory Factor-1 During Murine Endotoxemia.

Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.

Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock.

Evolving role of endovascular techniques for traumatic vascular injury: A changing landscape?

Changes in massive transfusion over time: An early shift in the right direction?