Chapter 21
Drugs for Peptic Ulcer Disease
Fisiopatologia dell'ulcera peptica: fattori dannosi
Peptic ulcers are sores in the mucosa of the stomach or duodenum.
The mucosal epithelium houses acid-secreting parietal and gastrin-secreting G cells.
The ...
Fisiopatologia dell'ulcera peptica: fattori di difesa della mucosa
Peptic ulcer disease, or PUD, involves discontinuous gastrointestinal tract lining due to gastric acid or pepsin secretion.
The mucus-bicarbonate barrier ...
Farmaci soppressori dell'acido per l'ulcera peptica: inibitori della pompa protonica
Two of the main contributors to peptic ulcer formation are H. pylori infections or NSAID use, both facilitating gastric acid production.
Gastric acid is ...
Farmaci soppressori dell'acido per l'ulcera peptica: antagonisti del recettore H2 dell'istamina
Histamine H2 receptors are G protein-coupled receptors located on the basolateral membrane of parietal cells.
Histamine released from ECL cells binds to ...
Farmaci soppressori dell'acido per l'ulcera peptica: antiacidi
In the gastric lumen, increased acid secretion can form or exacerbate ulcers in the mucosal layer.
Carbonate antacids, like sodium bicarbonate and calcium ...
Farmaci per l'ulcera peptica: sucralfato come agenti protettivi della mucosa
Recall that increased acid secretion in the gastric lumen disrupts mucosal defense mechanisms and weakens the mucus-bicarbonate barrier.
This enables ...
Farmaci per l'ulcera peptica: analoghi delle prostaglandine come agenti protettivi della mucosa
The gastric mucosa majorly produces prostaglandin E2 and I2 to protect cells from mucosal injury.
These bind to EP3 receptors, which couple with ...
Trattamento dell'Helicobacter pylori nelle ulcere peptiche: terapia antimicrobica
Helicobacter pylori or H. pylori, a gram-negative bacillus, thrives in the stomach's acidic environment, impairing somatostatin production. This ...
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