James Baker

Synthesis, characterization and stability of a luteinizing hormone-releasing hormone (LHRH)-functionalized poly(amidoamine) dendrimer conjugate.

E-mail, decisional styles, and rest breaks.

Acid-catalyzed rearrangement of fused alkylideneoxetanols.

Synthesis, characterization, and intracellular uptake of carboxyl-terminated poly(amidoamine) dendrimer-stabilized iron oxide nanoparticles.

Synthetic PAMAM-RGD conjugates target and bind to odontoblast-like MDPC 23 cells and the predentin in tooth organ cultures.

Synthetic strategies to epoxydiynes and a key synthon of the neocarzinostatin chromophore.

Tooth fairy abscess.

Specimen dilution improves sensitivity of the amplified Mycobacterium tuberculosis direct test for smear microscopy-positive respiratory specimens.

Comparative study of budesonide inhalation suspension and montelukast in young children with mild persistent asthma.

Cardiac-resynchronization therapy in heart failure with narrow QRS complexes.

Reducing events in patients with chronic heart failure (REDUCEhf ) study design: continuous hemodynamic monitoring with an implantable defibrillator.

The potential influence of CO2, as an agent for euthanasia, on the pharmacokinetics of basic compounds in rodents.

Evaluation of artificial intelligence based models for chemical biodegradability prediction.

Biosensing based on two-photon fluorescence measurements through optical fibers.

A novel, killed-virus nasal vaccinia virus vaccine.

CE of poly(amidoamine) succinamic acid dendrimers using a poly(vinyl alcohol)-coated capillary.

Preclinical antitumor efficacy evaluation of dendrimer-based methotrexate conjugates.

Dendrimer-epidermal growth factor conjugate displays superagonist activity.

Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers.

Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces Th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates.

Distress, coping, and blogging: comparing new myspace users by their intention to blog.

Investigation of tumor cell targeting of a dendrimer nanoparticle using a double-clad optical fiber probe.

Asthma control in pediatric patients treated with once-daily or twice-daily nebulized budesonide inhalation suspension (Pulmicort Respules).

Science and government. An Earth systems science agency.

Quantitative two-photon flow cytometry--in vitro and in vivo.

Poly(amidoamine) dendrimers on lipid bilayers I: Free energy and conformation of binding.

Sensitive molecular binding assay using a photonic crystal structure in total internal reflection.

Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement.

Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine.

Two-photon fluorescence correlation spectroscopy through a dual-clad optical fiber.

Habitat-mediated variation in predation risk by the American marten.

The implications of stochastic synthesis for the conjugation of functional groups to nanoparticles.

Interactions of poly(amidoamine) dendrimers with Survanta lung surfactant: the importance of lipid domains.

Snapping wrist due to an anomalous extensor indicis proprius: a case report.

Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial.

Cost-effectiveness of different strategies for amplified Mycobacterium tuberculosis direct testing for cases of pulmonary tuberculosis.

Control of the blue fluorescent protein with advanced evolutionary pulse shaping.

Current dendrimer applications in cancer diagnosis and therapy.

In vitro activities of a novel nanoemulsion against Burkholderia and other multidrug-resistant cystic fibrosis-associated bacterial species.

Tumor necrosis factor-related apoptosis-inducing ligand inhibits experimental autoimmune thyroiditis by the expansion of CD4+CD25+ regulatory T cells.

Extended cavity laser enhanced two-photon flow cytometry.

Patient-reported outcomes in adults with moderate to severe asthma after use of budesonide and formoterol administered via 1 pressurized metered-dose inhaler.

Blogging as a social tool: a psychosocial examination of the effects of blogging.

Control of two-photon fluorescence of common dyes and conjugated dyes.

Two-year results of a prospective, multi-site investigation of patient satisfaction and psychosocial status following cosmetic surgery.

Performance of the St. Jude Medical Riata leads.

A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma.

In situ reduction in photocycloadditions: a method to prevent secondary photoreactions.

The ABCD (Alternans Before Cardioverter Defibrillator) Trial: strategies using T-wave alternans to improve efficiency of sudden cardiac death prevention.

Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic Acid-conjugated dendrimers.

In Vivo Monitoring of Multiple Circulating Cell Populations Using Two-photon Flow Cytometry.

Perioperative management of acute and chronic anemia: has the pendulum swung too far?

Therapeutic efficacy of 2-methoxyestradiol microcrystals encapsulated within polyelectrolyte multilayers.

Development of a remanence measurement-based SQUID system with in-depth resolution for nanoparticle imaging.

Multifunctional dendrimer-modified multiwalled carbon nanotubes: synthesis, characterization, and in vitro cancer cell targeting and imaging.

When is prophylaxis for hereditary angioedema necessary?

Stoichiometry and Structure of Poly(amidoamine) Dendrimer-Lipid Complexes.

Targeting and detecting cancer cells using spontaneously formed multifunctional dendrimer-stabilized gold nanoparticles.

Mortality risk increases with natal dispersal distance in American martens.

The role of ganglioside GM1 in cellular internalization mechanisms of poly(amidoamine) dendrimers.

Comparison of the internalization of targeted dendrimers and dendrimer-entrapped gold nanoparticles into cancer cells.

Cationic nanoparticles induce nanoscale disruption in living cell plasma membranes.

Human plasma-mediated hypoxic activation of indolequinone-based naloxone pro-drugs.

Safety of daily albuterol in infants with a history of bronchospasm: a multi-center placebo controlled trial.

Spontaneous Formation of Functionalized Dendrimer-Stabilized Gold Nanoparticles.

Characterization of stability and nasal delivery systems for immunization with nanoemulsion-based vaccines.

Bromomaleimides: new reagents for the selective and reversible modification of cysteine.

Adverse reactions to vaccines.

Cationic poly(amidoamine) dendrimer induces lysosomal apoptotic pathway at therapeutically relevant concentrations.

Dendrimer-based tumor cell targeting of fibroblast growth factor-1.

Dendrimer-based nanoparticles for cancer therapy.

Targeting the efficacy of a dendrimer-based nanotherapeutic in heterogeneous xenograft tumors in vivo.

The mechanism of polyplex internalization into cells: testing the GM1/caveolin-1 lipid raft mediated endocytosis pathway.

Methotrexate delivery via folate targeted dendrimer-based nanotherapeutic platform.

Protein modification, bioconjugation, and disulfide bridging using bromomaleimides.

Targeted Dendrimeric Anticancer Prodrug: A Methotrexate-Folic Acid-Poly(amidoamine) Conjugate and a Novel, Rapid, "One Pot" Synthetic Approach.

A quantitative assessment of nanoparticle-ligand distributions: implications for targeted drug and imaging delivery in dendrimer conjugates.

Quantitative differentiation of dyes with overlapping one-photon spectra by femtosecond pulse shaping.

Understanding specific and nonspecific toxicities: a requirement for the development of dendrimer-based pharmaceuticals.

A Facile Hydrothermal Synthesis of Iron Oxide Nanoparticles with Tunable Magnetic Properties.

Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury.

The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug release.

Induction of Th17 cellular immunity with a novel nanoemulsion adjuvant.

Efficacy, immunogenicity and stability of a novel intranasal nanoemulsion-adjuvanted influenza vaccine in a murine model.

An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity.

Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate.

Real-time biomolecular binding detection using a sensitive photonic crystal biosensor.

Otolith stimulation induces c-Fos expression in vestibular and precerebellar nuclei in cats and squirrel monkeys.

Design, synthesis, and structure-activity relationship study of conformationally constrained analogs of indole-3-carboxamides as novel CB1 cannabinoid receptor agonists.

Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery.

Isolation and characterization of dendrimers with precise numbers of functional groups.

HER2 specific delivery of methotrexate by dendrimer conjugated anti-HER2 mAb.

Interactive Design Strategy for a Multi-Functional PAMAM Dendrimer-Based Nano-Therapeutic Using Computational Models and Experimental Analysis.

Label-free biosensing using a photonic crystal structure in a total-internal-reflection geometry.

RGD dendron bodies; synthetic avidity agents with defined and potentially interchangeable effector sites that can substitute for antibodies.

Identification and hit-to-lead optimization of a novel class of CB1 antagonists.

Fiber-optic multiphoton flow cytometry in whole blood and in vivo.

Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema.

Plasma-mediated release of morphine from synthesized prodrugs.

Influence of dendrimer surface charge on the bioactivity of 2-methoxyestradiol complexed with dendrimers.

Office-based oral immunotherapy for food allergy is safe and effective.

Making marine life count: a new baseline for policy.

Design, synthesis, and structure-activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists.

Progress in cancer nanotechnology.

The discovery of novel indole-2-carboxamides as cannabinoid CB(1) receptor antagonists.

Design, synthesis, and structure-activity relationships of indole-3-heterocycles as agonists of the CB1 receptor.

Creation and validation of the personal blogging style scale.

An opportunistic validation of studies on the psychosocial benefits of blogging.

Troponins: redefining their limits.

New Dendrimers: Synthesis and Characterization of Popam - Pamam Hybrid Dendrimers.

In situ maleimide bridging of disulfides and a new approach to protein PEGylation.

Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists.

The design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists.

Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists.

Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.

Surface interaction and behavior of poly(amidoamine) dendrimers: deformability and lipid bilayer disruption.

Copper-free click conjugation of methotrexate to a PAMAM dendrimer platform.

Design, synthesis and structure-activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate.

Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand-Nanoparticle Distributions.

Design, synthesis, and biological functionality of a dendrimer-based modular drug delivery platform.

The need to pursue and publish clinical trials in nanomedicine.

The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.

Polyvalent saccharide-functionalized generation 3 poly(amidoamine) dendrimer-methotrexate conjugate as a potential anticancer agent.

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis.

Assessment and treatment of preoperative anemia: Continuing Professional Development.

Intranasal immunization of ferrets with commercial trivalent influenza vaccines formulated in a nanoemulsion-based adjuvant.

Acetonitrile shortage: use of isopropanol as an alternative elution system for ultra/high performance liquid chromatography.

Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.

Identification and optimisation of novel sulfonamide, selective vasopressin V1B receptor antagonists.

Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis.

Synthesis and evaluation of highly potent GABA(A) receptor antagonists based on gabazine (SR-95531).

Targeted dendrimer chemotherapy in an animal model for head and neck squamous cell carcinoma.

Bioanalytical Screening of Riboflavin Antagonists for Targeted Drug Delivery - A Thermodynamic and Kinetic Study.

Optimisation of pharmacokinetic properties to afford an orally bioavailable and selective V1A receptor antagonist.

Bromopyridazinedione-mediated protein and peptide bioconjugation.

mTor plays an important role in odontoblast differentiation.

Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood.

A novel inactivated intranasal respiratory syncytial virus vaccine promotes viral clearance without Th2 associated vaccine-enhanced disease.

Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles.

Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists.

De novo pudendal neuropathy after TOT-O surgery for stress urinary incontinence.

Naloxone pro-drug rescues morphine induced respiratory depression in Sprague-Dawley rats.

All hazards planning and response in the Veterans Administration.

Bromomaleimide-linked bioconjugates are cleavable in mammalian cells.

Dendrimer-based multivalent methotrexates as dual acting nanoconjugates for cancer cell targeting.

Polymeric dibromomaleimides as extremely efficient disulfide bridging bioconjugation and pegylation agents.

Biophysical characterization of a riboflavin-conjugated dendrimer platform for targeted drug delivery.

A photochemical approach for controlled drug release in targeted drug delivery.

Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate.

Bifunctional PAMAM dendrimer conjugates of folic acid and methotrexate with defined ratio.

Induction of immune tolerance in mice with a novel mucosal nanoemulsion adjuvant and self-antigen.

Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain.

Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides.

[2+2] photocycloadditions of thiomaleimides.

The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry.

Optical fiber-based in vivo quantification of growth factor receptors.

Nanoemulsion mucosal adjuvant uniquely activates cytokine production by nasal ciliated epithelium and induces dendritic cell trafficking.

Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic.

Treatment with a novel topical nanoemulsion (NB-001) speeds time to healing of recurrent cold sores.

Specific and Cooperative Interactions between Oximes and PAMAM Dendrimers As Demonstrated by (1)H NMR Study.

Nanoemulsion W805EC improves immune responses upon intranasal delivery of an inactivated pandemic H1N1 influenza vaccine.

Fluorescence photoactivation by intermolecular proton transfer.

Sustained analgesia achieved through esterase-activated morphine prodrugs complexed with PAMAM dendrimer.

Massive transfusion in the trauma patient: Continuing Professional Development.

Best practices for purification and characterization of PAMAM dendrimer.

Cloudy forecast for weather satellite data.

Dendrimer-based multivalent vancomycin nanoplatform for targeting the drug-resistant bacterial surface.

Nanoemulsion nasal adjuvant W₈₀5EC induces dendritic cell engulfment of antigen-primed epithelial cells.

Postoperative performance of the Quartet® left ventricular heart lead.

Paclitaxel-conjugated PAMAM dendrimers adversely affect microtubule structure through two independent modes of action.

Fluorogenic 'click-on' dendrimer reporter for rapid profiling of cell proliferation.

Selective virus detection in complex sample matrices with photonic crystal optical cavities.

Polyplex exposure inhibits cell cycle, increases inflammatory response, and can cause protein expression without cell division.

Turn-on, fluorescent nuclear stains with live cell compatibility.

Reversible protein affinity-labelling using bromomaleimide-based reagents.

Live imaging of multicolor-labeled cells in Drosophila.

Nanofiltered C1 esterase inhibitor (human) for hereditary angioedema attacks in pregnant women.

Climate change as an intergenerational problem.

Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'.

Efficacy and safety of recombinant C1 inhibitor for the treatment of hereditary angioedema attacks: a North American open-label study.

Design considerations for PAMAM dendrimer therapeutics.

Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification.

Design and in vitro validation of multivalent dendrimer methotrexates as a folate-targeting anticancer therapeutic.

Why I believe nanoparticles are crucial as a carrier for targeted drug delivery.

Activation of BODIPY fluorescence by the photoinduced dealkylation of a pyridinium quencher.

OT-II TCR transgenic mice fail to produce anti-ovalbumin antibodies upon vaccination.

Applications of nanotechnology for immunology.

Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.

DNA condensation by partially acetylated poly(amido amine) dendrimers: effects of dendrimer charge density on complex formation.

Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer.

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.

Influence of blood donation on the incidence of plateau at [Formula: see text] 2max.

Budesonide inhalation suspension versus montelukast in children aged 2 to 4 years with mild persistent asthma.

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents.

Profiling inflammatory responses with microfluidic immunoblotting.

Formulation and Characterization of Nanoemulsion Intranasal Adjuvants: Effects of Surfactant Composition on Mucoadhesion and Immunogenicity.

Intranasal immunization with W 80 5EC adjuvanted recombinant RSV rF-ptn enhances clearance of respiratory syncytial virus in a mouse model.

Assessing the barriers to image-guided drug delivery.

Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts.

Characterization of a Novel Transgenic Mouse Tumor Model for Targeting HER2+ Cancer Stem Cells.