Steven Mennerick

Contribution of presynaptic Na(+) channel inactivation to paired-pulse synaptic depression in cultured hippocampal neurons.

3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists.

Ethanol-induced death of postnatal hippocampal neurons.

Feeding hungry neurons: astrocytes deliver food for thought.

Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.

Homeostatic effects of depolarization on Ca2+ influx, synaptic signaling, and survival.

Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.

Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current.

Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia.

Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.

Selective effects of potassium elevations on glutamate signaling and action potential conduction in hippocampus.

Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors.

Plastic elimination of functional glutamate release sites by depolarization.

Slow actions of neuroactive steroids at GABAA receptors.

Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain.

New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids.

Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.

Reluctant vesicles contribute to the total readily releasable pool in glutamatergic hippocampal neurons.

Action potential fidelity during normal and epileptiform activity in paired soma-axon recordings from rat hippocampus.

Reluctant vesicles coaxed into the limelight.

An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers.

Neurosteroid access to the GABAA receptor.

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

Synaptic vesicles: turning reluctance into action.

Homeostatic regulation of glutamate release in response to depolarization.

Physiological activity depresses synaptic function through an effect on vesicle priming.

Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.

Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers.

A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons.

Action potential initiation and propagation in CA3 pyramidal axons.

Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.

Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens.

Mechanisms of neurosteroid interactions with GABA(A) receptors.

Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol.

Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation.

Astrocyte membrane responses and potassium accumulation during neuronal activity.

Vesicle pool heterogeneity at hippocampal glutamate and GABA synapses.

Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes.

Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors.

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo.

A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing.

High threshold, proximal initiation, and slow conduction velocity of action potentials in dentate granule neuron mossy fibers.

Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system.

NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue.

Adenylyl cyclases 1 and 8 initiate a presynaptic homeostatic response to ethanol treatment.

The influence of the membrane on neurosteroid actions at GABA(A) receptors.

The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction.

Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors.

Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons.

Dynamic modulation of phasic and asynchronous glutamate release in hippocampal synapses.

Comparative effects of heterologous TRPV1 and TRPM8 expression in rat hippocampal neurons.

A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors.

Diverse voltage-sensitive dyes modulate GABAA receptor function.

The sticky issue of neurosteroids and GABA(A) receptors.

Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions.

Rapid activation of dormant presynaptic terminals by phorbol esters.

Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.

Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.

Differential effects of axon initial segment and somatodendritic GABAA receptors on excitability measures in rat dentate granule neurons.

Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses.

Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity.

Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults.

Don't curse the darkness, light a candle: fluorescence studies of axon excitability.

Presynaptically Silent Synapses: Dormancy and Awakening of Presynaptic Vesicle Release.

Characteristics of α4/δ-containing concatemeric GABA(A) receptors expressed in Xenopus oocytes.

Excitotoxicity triggered by Neurobasal culture medium.

Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death.

Neurosteroid Analogues. 17. Inverted Binding Orientations of Androsterone Enantiomers at the Steroid Potentiation Site on γ-Aminobutyric Acid Type A Receptors.

Crosstalk between synaptic receptors mediates NMDA-induced suppression of inhibition.