Melody A. Swartz

Physiological 3D tissue model of the airway wall and mucosa.

Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression.

Fibroblast alignment under interstitial fluid flow using a novel 3-D tissue culture model.

The role of interstitial stress in lymphatic function and lymphangiogenesis.

Interstitial flow as a guide for lymphangiogenesis.

An in vitro airway wall model of remodeling.

Signaling in morphogenesis: transport cues in morphogenesis.

Interstitial flow differentially stimulates blood and lymphatic endothelial cell morphogenesis in vitro.

Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody.

Overexpression of VEGF-C causes transient lymphatic hyperplasia but not increased lymphangiogenesis in regenerating skin.

Dendritic-cell trafficking to lymph nodes through lymphatic vessels.

Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro.

Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism.

Mechanobiology in the third dimension.

Microarray analysis of VEGF-C responsive genes in human lymphatic endothelial cells.

Mechanisms of interstitial flow-induced remodeling of fibroblast-collagen cultures.

Capturing complex 3D tissue physiology in vitro.

In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles.

Extracellular matrix remodeling by dynamic strain in a three-dimensional tissue-engineered human airway wall model.

Autologous morphogen gradients by subtle interstitial flow and matrix interactions.

Characterization of lymphangiogenesis in a model of adult skin regeneration.

A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.

Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9.

Effects of extracellular fiber architecture on cell membrane shear stress in a 3D fibrous matrix.

Targeting dendritic cells with biomaterials: developing the next generation of vaccines.

Engineered blood and lymphatic capillaries in 3-D VEGF-fibrin-collagen matrices with interstitial flow.

A driving force for change: interstitial flow as a morphoregulator.

Regulation of lymphatic capillary regeneration by interstitial flow in skin.

Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis.

Bond-detach lithography: a method for micro/nanolithography by precision PDMS patterning.

Interstitial flow and its effects in soft tissues.

An ultra-thin PDMS membrane as a bio/micro-nano interface: fabrication and characterization.

Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling.

Exploiting lymphatic transport and complement activation in nanoparticle vaccines.

Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model.

Lymphatic drainage function and its immunological implications: from dendritic cell homing to vaccine design.

Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype.

3D collagen cultures under well-defined dynamic strain: a novel strain device with a porous elastomeric support.

In vitro models of inhalation toxicity and disease. The report of a FRAME workshop.

An agarose-based microfluidic platform with a gradient buffer for 3D chemotaxis studies.

A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics.

Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration.

Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment.

Materials engineering for immunomodulation.

A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: development, characterization, and applications.

Cells in 3D matrices under interstitial flow: effects of extracellular matrix alignment on cell shear stress and drag forces.

Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema.

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium.

Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21.

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation.

PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration.

Engineering complement activation on polypropylene sulfide vaccine nanoparticles.

Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts.

Regulation of tumor invasion by interstitial fluid flow.

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19.

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis.

Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival.

PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: tumor immunotoxicity in B16F10 melanoma.

Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination.

Multiscale modeling of lymphatic drainage from tissues using homogenization theory.

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber.

Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity.

Tumor microenvironment complexity: emerging roles in cancer therapy.

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes.

Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization.

Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer.

VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics.

Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage.

Engineering approaches to immunotherapy.

Nanoparticle size influences the magnitude and quality of mucosal immune responses after intranasal immunization.

ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis.

Interstitial flow in a 3D microenvironment increases glioma invasion by a CXCR4-dependent mechanism.

Intravital immunofluorescence for visualizing the microcirculatory and immune microenvironments in the mouse ear dermis.

Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles.

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice.

Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia.

Peripherally administered nanoparticles target monocytic myeloid cells, secondary lymphoid organs and tumors in mice.

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165.

Cooperative roles of SDF-1α and EGF gradients on tumor cell migration revealed by a robust 3D microfluidic model.

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis.

VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy.

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response.

Engineering synthetic vaccines using cues from natural immunity.

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose.

Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing.

Emerging roles of lymphatic endothelium in regulating adaptive immunity.

Introduction to the special issue on lymphangiogenesis in inflammation.