Jeffrey C. Edberg

Differential Regulation of Fcgamma Receptor Isoforms: Implications for Therapeutic Intervention.

The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis.

Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus.

Diversity and duplicity: human FCgamma receptors in host defense and autoimmunity.

A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients.

A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling.

Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins.

A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus.

A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function.

The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept.

Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain.

Time to renal disease and end-stage renal disease in PROFILE: a multiethnic lupus cohort.

Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients.

Anti-GD3 monoclonal antibody effects on lymphocytes and antibody-dependent cellular cytotoxicity.

Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus.

FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA.

Clinical and genetic risk factors for pneumonia in systemic lupus erythematosus.

Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects.

Fc receptor genes and the systemic lupus erythematosus diathesis.

IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1.

Genetic variation in the CRP promoter: association with systemic lupus erythematosus.

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.

Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion.

Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort.

Functional expression of IgA receptor FcalphaRI on human platelets.

An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.

Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.

Wegener's granulomatosis: a model of auto-antibodies in mucosal autoimmunity.

A polymorphism within IL21R confers risk for systemic lupus erythematosus.

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.

The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells.

ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry.

Retraction: an African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.

Pathways: Strategies for susceptibility genes in SLE.

Variations in CCL3L gene cluster sequence and non-specific gene copy numbers.

Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans.

The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans.

The role of genetic variation near interferon-kappa in systemic lupus erythematosus.

Alpha₁-antitrypsin deficiency-related alleles Z and S and the risk of Wegener's granulomatosis.

A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia.

Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study.

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.

Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21.

Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus.

A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia.

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups.

Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease.

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.

FAS mRNA editing in Human Systemic Lupus Erythematosus.

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.

Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G.

Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions.

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus.

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.

Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans.

IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis.

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study.

Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis.

Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries.

Role of activating FcγR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response.

A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.

Genetic risk factors for thrombosis in systemic lupus erythematosus.

Two independent functional risk haplotypes in TNIP1 are associated with systemic lupus erythematosus.

Impact of genetic ancestry and socio-demographic status on the clinical expression of systemic lupus erythematosus in Amerindian-European populations.

Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups.

The unique cytoplasmic domain of human FcγRIIIA regulates receptor-mediated function.

Brief Report: Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians.

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production.

MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus.

Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.

Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.

Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed.

FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response.

Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils.

PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes.

ABIN1 Dysfunction as a Genetic Basis for Lupus Nephritis.

Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression.

Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses.

FcγRIIIa SNPs and haplotypes affect human IgG binding and association with lupus nephritis in African Americans.

End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.

A polymorphism in TLR2 is associated with arterial thrombosis in a multi-ethnic SLE population.

Fcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African Americans.

Lupus Nephritis Susceptibility Loci in Women with Systemic Lupus Erythematosus.