Beilei Lei

Changes in mRNA expression induced by sustained noradrenaline stimulation are different for alpha1-adrenoceptor subtypes in HEK293 cells.

Cellular trafficking of human alpha1a-adrenergic receptors is continuous and primarily agonist-independent.

Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function.

The alpha1a-adrenergic receptor occupies membrane rafts with its G protein effectors but internalizes via clathrin-coated pits.

QSAR study of malonyl-CoA decarboxylase inhibitors using GA-MLR and a new strategy of consensus modeling.

A concise approach to 1,11-didechloro-6-methyl-4'-O-demethyl rebeccamycin and its binding to human serum albumin: fluorescence spectroscopy and molecular modeling method.

Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of thiazolone derivatives as hepatitis C virus NS5B polymerase allosteric inhibitors.

Interaction of anthracycline disaccharide with human serum albumin: investigation by fluorescence spectroscopic technique and modeling studies.

A novel method for protein-ligand binding affinity prediction and the related descriptors exploration.

Study of the interaction of aglycon of daunorubicin with human serum albumin by spectroscopy and modeling.

Molecular modeling studies of vascular endothelial growth factor receptor tyrosine kinase inhibitors using QSAR and docking.

Novel approaches for retention time prediction of oligonucleotides in ion-pair reversed-phase high-performance liquid chromatography.

Specific interaction of 4'-O-(a-l-Cladinosyl) daunorubicin with human serum albumin: The binding site II on HSA molecular using spectroscopy and modeling.

Global, local and novel consensus quantitative structure-activity relationship studies of 4-(Phenylaminomethylene) isoquinoline-1, 3 (2H, 4H)-diones as potent inhibitors of the cyclin-dependent kinase 4.

Lipid rafts constrain basal alpha(1A)-adrenergic receptor signaling by maintaining receptor in an inactive conformation.

A new strategy to improve the predictive ability of the local lazy regression and its application to the QSAR study of melanin-concentrating hormone receptor 1 antagonists.

Rational prediction of the herbicidal activities of novel protoporphyrinogen oxidase inhibitors by quantitative structure-activity relationship model based on docking-guided active conformation.

Molecular modeling studies of Rho kinase inhibitors using molecular docking and 3D-QSAR analysis.

Global and local prediction of protein folding rates based on sequence autocorrelation information.

Molecular basis of the selectivity of the immunoproteasome catalytic subunit LMP2-specific inhibitor revealed by molecular modeling and dynamics simulations.

Structure-based quantitative structure-activity relationship studies of checkpoint kinase 1 inhibitors.

Structural requirements of isoquinolones as novel selective c-Jun N-terminal kinase 1 inhibitors: 2D and 3D QSAR analyses.

In silico prediction of deleterious single amino acid polymorphisms from amino acid sequence.

A bright approach to the immunoproteasome: development of LMP2/β1i-specific imaging probes.

The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage.

Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: A translational approach.

TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice.

Fundamental reaction pathway and free energy profile for inhibition of proteasome by Epoxomicin.

Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.

Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.

Interaction between sex and apolipoprotein e genetic background in a murine model of intracerebral hemorrhage.

Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage.

Stimulation of α1a adrenergic receptors induces cellular proliferation or antiproliferative hypertrophy dependent solely on agonist concentration.