Eng H. Lo

Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats.

Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke.

Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects.

Secretion of matrix metalloproteinase-2 and -9 after mechanical trauma injury in rat cortical cultures and involvement of MAP kinase.

Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress.

Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases.

Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion.

Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model.

Gene transfer of the Caenorhabditis elegans n-3 fatty acid desaturase inhibits neuronal apoptosis.

Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: mechanical versus embolic focal ischemia in spontaneously hypertensive rats.

Downregulation of matrix metalloproteinase-9 and attenuation of edema via inhibition of ERK mitogen activated protein kinase in traumatic brain injury.

Junctional complexes of the blood-brain barrier: permeability changes in neuroinflammation.

Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study.

Neurogenesis and apoptotic cell death.

Mechanisms, challenges and opportunities in stroke.

Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes.

Antiactin-targeted immunoliposomes ameliorate tissue plasminogen activator-induced hemorrhage after focal embolic stroke.

Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator.

Interactions between p38 mitogen-activated protein kinase and caspase-3 in cerebral endothelial cell death after hypoxia-reoxygenation.

Triggers and mediators of hemorrhagic transformation in cerebral ischemia.

Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia.

tPA and proteolysis in the neurovascular unit.

Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB.

Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells.

Cortical spreading depression activates and upregulates MMP-9.

Induction of caspase-mediated cell death by matrix metalloproteinases in cerebral endothelial cells after hypoxia-reoxygenation.

The neurotoxicity of tissue plasminogen activator?

Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke.

Combination stroke therapy: easy as APC?

Exciting, radical, suicidal: how brain cells die after stroke.

Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity.

Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia.

Extracellular proteolytic pathophysiology in the neurovascular unit after stroke.

Measurements of BOLD/CBV ratio show altered fMRI hemodynamics during stroke recovery in rats.

A pilot study of normobaric oxygen therapy in acute ischemic stroke.

Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia.

Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging.

Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia.

Granulocyte colony-stimulating factor enhances angiogenesis after focal cerebral ischemia.

Advances in stroke neuroprotection: hyperoxia and beyond.

Different strokes for rodent folks.

Role of matrix metalloproteinases in delayed cortical responses after stroke.

Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke.

Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models.

Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke.

fMRI of delayed albumin treatment during stroke recovery in rats: implication for fast neuronal habituation in recovering brains.

Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes.

Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage.

Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes.

Baicalein and 12/15-lipoxygenase in the ischemic brain.

Neural stem cell transplant survival in brains of mice: assessing the effect of immunity and ischemia by using real-time bioluminescent imaging.

Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke.

Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators.

TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice.

Cell-cell signaling in the neurovascular unit.

Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia.

Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice.

Novel lipoxygenase inhibitors as neuroprotective reagents.

Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study.

Effect of neuregulin-1 on histopathological and functional outcome after controlled cortical impact in mice.

Advances in emerging nondrug therapies for acute stroke 2007.

Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemia.

Multiphasic roles for matrix metalloproteinases after stroke.

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain.

MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke.

Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke.

Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia.

Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke.

A new penumbra: transitioning from injury into repair after stroke.

Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons.

Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia.

Targeting extracellular matrix proteolysis for hemorrhagic complications of tPA stroke therapy.

Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons.

Neuregulin-1 signaling in brain endothelial cells.

Green tea polyphenol (-)-epigallocatechin gallate reduces neuronal cell damage and up-regulation of MMP-9 activity in hippocampal CA1 and CA2 areas following transient global cerebral ischemia.

Experimental model of warfarin-associated intracerebral hemorrhage.

Reperfusion injury after stroke: neurovascular proteases and the blood-brain barrier.

Extension of the thrombolytic time window with minocycline in experimental stroke.

Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes.

Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death.

The neurovascular unit in health and disease: introduction.

Dysfunctional cell-cell signaling in the neurovascular unit as a paradigm for central nervous system disease.

Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex.

Characterization of cerebrovascular responses to hyperoxia and hypercapnia using MRI in rat.

Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia.

CD47 gene knockout protects against transient focal cerebral ischemia in mice.

Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro.

Update of the stroke therapy academic industry roundtable preclinical recommendations.

Neuroprotective roles and mechanisms of neuroglobin.

Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage.

An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells.

Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro.

Mechanisms and targets for angiogenic therapy after stroke.

Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1.

Matrix metalloprotease regulation of neuropathic pain.

Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats.

Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke.

T time in the brain.

Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke.

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress.

Oligovascular signaling in white matter stroke.

Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling.

Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro.

Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice.

Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway.

Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke.

Experimental models for analysis of oligodendrocyte pathophysiology in stroke.

Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice.

Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes.

Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells.

Stroke: working toward a prioritized world agenda.

Stroke: working toward a prioritized world agenda.

Stroke: working toward a prioritized world agenda.

Amelioration of inflammation and cytotoxicity by dipyridamole in brain endothelial cells.

The science of stroke: mechanisms in search of treatments.

High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia.

Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue.

Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy.

Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice.

Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke.

Degeneration and repair in central nervous system disease.

Fingolimod provides long-term protection in rodent models of cerebral ischemia.

Proteomic temporal profile of human brain endothelium after oxidative stress.

Fingolimod provides long-term protection in rodent models of cerebral ischemia.

Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke.

Antiplatelet pretreatment does not increase hematoma volume in experimental intracerebral hemorrhage.

Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage.

γ-glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood-brain barrier permeability after experimental brain trauma.

Stroke-related translational research.

Decreased cerebrovascular brain-derived neurotrophic factor-mediated neuroprotection in the diabetic brain.

Cellular mechanisms of neurovascular damage and repair after stroke.

Intracranial hemorrhage: mechanisms of secondary brain injury.

Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection.

Fast radio-frequency enforced steady state (FRESS) spin echo MRI for quantitative T(2) mapping: minimizing the apparent repetition time (TR) dependence for fast T(2) measurement.

Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells.

Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage.

Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice.

Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage.

Neuroglobin is an endogenous neuroprotectant for retinal ganglion cells against glaucomatous damage.

Cortical excitation and inhibition following focal traumatic brain injury.

Recombinant activated coagulation factor VII and prothrombin complex concentrates are equally effective in reducing hematoma volume in experimental warfarin-associated intracerebral hemorrhage.

A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes.

Plasmalemma permeability and necrotic cell death phenotypes after intracerebral hemorrhage in mice.

Kollidon VA64, a membrane-resealing agent, reduces histopathology and improves functional outcome after controlled cortical impact in mice.

Opportunities and Challenges in Omics.

Proteomic Protease Substrate Profiling of tPA Treatment in Acute Ischemic Stroke Patients: A Step Toward Individualizing Thrombolytic Therapy at the Bedside.

Traumatic brain injury during warfarin anticoagulation - An experimental study in mice.

Plasma biomarker may help to distinguish acute CVST from non-thrombotic CVSS in emergency.

Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases.