Sina Bavari

Production and purification of a recombinant Staphylococcal enterotoxin B vaccine candidate expressed in Escherichia coli.

Lipid raft microdomains: a gateway for compartmentalized trafficking of Ebola and Marburg viruses.

Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination.

Humanlike immune response of human leukocyte antigen-DR3 transgenic mice to staphylococcal enterotoxins: a novel model for superantigen vaccines.

Lethal shock induced by streptococcal pyrogenic exotoxin A in mice transgenic for human leukocyte antigen-DQ8 and human CD4 receptors: implications for development of vaccines and therapeutics.

Molecular mechanisms of filovirus cellular trafficking.

Correlation of body temperature with protection against staphylococcal enterotoxin B exposure and use in determining vaccine dose-schedule.

Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity.

Mutational effects on protein folding stability and antigenicity: the case of streptococcal pyrogenic exotoxin A.

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation.

Ebola virus-like particles protect from lethal Ebola virus infection.

In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.

Identification of small molecule inhibitors of anthrax lethal factor.

Generation of Marburg virus-like particles by co-expression of glycoprotein and matrix protein.

Time-lapse confocal imaging of development of Bacillus anthracis in macrophages.

Role of natural killer cells in innate protection against lethal ebola virus infection.

Ebola and Marburg virus-like particles activate human myeloid dendritic cells.

Marburg virus-like particles protect guinea pigs from lethal Marburg virus infection.

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

Purified Bacillus anthracis lethal toxin complex formed in vitro and during infection exhibits functional and biological activity.

Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization.

Human leukocyte antigen-DQ8 transgenic mice: a model to examine the toxicity of aerosolized staphylococcal enterotoxin B.

Association of ebola virus matrix protein VP40 with microtubules.

The evolving field of biodefence: therapeutic developments and diagnostics.

Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections.

Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis.

Analysis of Ebola virus and VLP release using an immunocapture assay.

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.

Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection.

Filovirus-like particles as vaccines and discovery tools.

Anthrax biosensor, protective antigen ion channel asymmetric blockade.

Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators.

Integrated bioassays in microfluidic devices: botulinum toxin assays.

Reemergence of monkeypox: prevalence, diagnostics, and countermeasures.

Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.

VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice.

Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor.

Antisense treatments for biothreat agents.

Dominance of human innate immune responses in primary Francisella tularensis live vaccine strain vaccination.

Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization.

Anthrax lethal toxin impairs innate immune functions of alveolar macrophages and facilitates Bacillus anthracis survival.

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.

Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery.

Transcriptome analysis of human immune responses following live vaccine strain (LVS) Francisella tularensis vaccination.

Chemical genetic screening identifies critical pathways in anthrax lethal toxin-induced pathogenesis.

NKp30-dependent cytolysis of filovirus-infected human dendritic cells.

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease.

Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction.

Ebola virus inactivation with preservation of antigenic and structural integrity by a photoinducible alkylating agent.

Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents.

Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge.

Development of a model for marburgvirus based on severe-combined immunodeficiency mice.

Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses.

Functional CD8+ T cell responses in lethal Ebola virus infection.

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.

Monovalent virus-like particle vaccine protects guinea pigs and nonhuman primates against infection with multiple Marburg viruses.

Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A.

Sizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols).

A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate.

Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore.

Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection.

Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.

Development and characterization of a mouse model for Marburg hemorrhagic fever.

Filovirus infections.

Development of a broad-spectrum antiviral with activity against Ebola virus.

Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains.

Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection.

Discovery of common marburgvirus protective epitopes in a BALB/c mouse model.

Generation of heterogeneous memory T cells by live attenuated tularemia vaccine in humans.

Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies.

Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis.

Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors.

Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.

Ebola virus uses clathrin-mediated endocytosis as an entry pathway.

Gaining ground: assays for therapeutics against botulinum neurotoxin.

Antiviral activity of a small-molecule inhibitor of filovirus infection.

Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A.

3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells.

Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.

Development of high-content imaging assays for lethal viral pathogens.

Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.

Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen.

The rapidly advancing field of biodefense benefits many other, critical public health concerns.

The osmolyte trimethylamine N-oxide (TMAO) increases the proteolytic activity of botulinum neurotoxin light chains A, B, and E: implications for enhancing analytical assay sensitivity.

Advanced antisense therapies for postexposure protection against lethal filovirus infections.

Assembly of a functional Machupo virus polymerase complex.

Analysis of Botulinum Neurotoxin Serotype A Metalloprotease Inhibitors: Analogs of a Chemotype for Therapeutic Development in the Context of a Three-Zone Pharmacophore.

Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease.

Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses.

Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B.

Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

Identification of a small-molecule entry inhibitor for filoviruses.

Key genomic changes necessary for an in vivo lethal mouse marburgvirus variant selection process.

Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice.

Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.

Crimean-Congo hemorrhagic fever: current and future prospects of vaccines and therapies.

Inhibition of Ebola virus entry by a C-peptide targeted to endosomes.

Development and characterization of rabbit and mouse antibodies against ebolavirus envelope glycoproteins.

Filovirus vaccines.

A STAT-1 knockout mouse model for Machupo virus pathogenesis.

Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry.

Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry.

Correlates of immunity to filovirus infection.

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity.

Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors.

Evaluation of perceived threat differences posed by filovirus variants.

Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.

Humanized mice as a preclinical tool for infectious disease and biomedical research.

Advanced morpholino oligomers: a novel approach to antiviral therapy.

The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.

Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses.

Nonhuman primates as models for the discovery and development of ebolavirus therapeutics.

Assembly of Ebola virus matrix protein VP40 is regulated by latch-like properties of N and C terminal tails.

Therapeutics for filovirus infection: traditional approaches and progress towards in silico drug design.

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.

The International Code of Virus Classification and Nomenclature (ICVCN): proposal to delete Rule 3.41.

Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae.

A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor.

Shedding light on filovirus infection with high-content imaging.

Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.

High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infection.

Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections.

Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency.

Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection.

Standardization of the filovirus plaque assay for use in preclinical studies.

The impact of regulations, safety considerations and physical limitations on research progress at maximum biocontainment.

Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae.

Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for yersinia pestis infection.

Characterization of a putative filovirus vaccine: virus-like particles.

The International Code of Virus Classification and Nomenclature (ICVCN): proposal for text changes for improved differentiation of viral taxa and viruses.

Predictive systems biology approach to broad-spectrum, host-directed drug target discovery in infectious diseases.

A systematic screen of FDA-approved drugs for inhibitors of biological threat agents.

Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.

IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.

The C terminus of the catalytic domain of type A botulinum neurotoxin may facilitate product release from the active site.

Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway.

4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity.

Characterization of the Burkholderia thailandensis SOS response by using whole-transcriptome shotgun sequencing.

Anthrax toxin-induced rupture of artificial lipid bilayer membranes.

Ebola virus-like particles stimulate type I interferons and proinflammatory cytokine expression through the toll-like receptor and interferon signaling pathways.

Nonhuman transferrin receptor 1 is an efficient cell entry receptor for Ocozocoautla de Espinosa virus.

Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA.

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

Reactive oxygen species activate NFκB (p65) and p53 and induce apoptosis in RVFV infected liver cells.

Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery.

Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns.

Toll-like receptor agonist augments virus-like particle-mediated protection from Ebola virus with transient immune activation.

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

TrkA in vivo function is negatively regulated by ubiquitination.

Marburgvirus hijacks nrf2-dependent pathway by targeting nrf2-negative regulator keap1.

Induced IL-10 splice altering approach to antiviral drug discovery.

Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

Multi-faceted proteomic characterization of host protein complement of Rift Valley fever virus virions and identification of specific heat shock proteins, including HSP90, as important viral host factors.

Applications of In Vivo Imaging in the Evaluation of the Pathophysiology of Viral and Bacterial Infections and in Development of Countermeasures to BSL3/4 Pathogens.

HSPA5 is an essential host factor for Ebola virus infection.

High content image-based screening of a protease inhibitor library reveals compounds broadly active against Rift Valley fever virus and other highly pathogenic RNA viruses.

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names.

Vaccine adjuvant uses of poly-IC and derivatives.

Recent Advances in Botulinum Neurotoxin Inhibitor Development.

High-Content Image-Based Screening of a Signal Transduction Pathway Inhibitor Small-Molecule Library against Highly Pathogenic RNA Viruses.