Arturo Casadevall

Intracellular pathogenic bacteria and fungi--a case of convergent evolution?

Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells.

Capsule of Cryptococcus neoformans grows by enlargement of polysaccharide molecules.

NIH peer review reform--change we need, or lipstick on a pig?

A role for vesicular transport of macromolecules across cell walls in fungal pathogenesis.

Radioimmunotherapy of infectious diseases.

Rethinking T cell immunity in oropharyngeal candidiasis.

Sec6-dependent sorting of fungal extracellular exosomes and laccase of Cryptococcus neoformans.

Is peer review censorship?

Reproducible science.

Antibody-mediated immobilization of Cryptococcus neoformans promotes biofilm formation.

The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes.

Structural and functional properties of the Trichosporon asahii glucuronoxylomannan.

Radioimmunotherapy of experimental human metastatic melanoma with melanin-binding antibodies and in combination with dacarbazine.

Vesicular transport across the fungal cell wall.

The still obscure attributes of cryptococcal glucuronoxylomannan.

Involvement of glycoreceptors in galactoxylomannan-induced T cell death.

The capsule of the fungal pathogen Cryptococcus neoformans.

The common Cryptococcus neoformans glucuronoxylomannan M2 motif elicits non-protective antibodies.

Lipophilic dye staining of Cryptococcus neoformans extracellular vesicles and capsule.

The case for pathogen-specific therapy.

Mechanistic science.

Role for chitin and chitooligomers in the capsular architecture of Cryptococcus neoformans.

Identification of linear epitopes in Bacillus anthracis protective antigen bound by neutralizing antibodies.

Phagocytosis inhibits F-actin-enriched membrane protrusions stimulated by fractalkine (CX3CL1) and colony-stimulating factor 1.

Important science--it's all about the SPIN.

Galactoxylomannan-mediated immunological paralysis results from specific B cell depletion in the context of widespread immune system damage.

The elastic properties of the Cryptococcus neoformans capsule.

Radiolabeled antibodies to Bacillus anthracis toxins are bactericidal and partially therapeutic in experimental murine anthrax.

Virulence factors and their mechanisms of action: the view from a damage-response framework.

Resistance of melanized yeast cells of Paracoccidioides brasiliensis to antimicrobial oxidants and inhibition of phagocytosis using carbohydrates and monoclonal antibody to CD18.

Vesicle-associated melanization in Cryptococcus neoformans.

Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannan.

Physico-chemical evaluation of rationally designed melanins as novel nature-inspired radioprotectors.

The use of chitosan to damage Cryptococcus neoformans biofilms.

The "nuclearization" of biology is a threat to health and security.

Vertebrate endothermy restricts most fungi as potential pathogens.

Murine IgG1 and IgG3 isotype switch variants promote phagocytosis of Cryptococcus neoformans through different receptors.

Fcgamma receptor cross-linking stimulates cell proliferation of macrophages via the ERK pathway.

Monoclonal antibody-based therapies for microbial diseases.

Lost in translation--basic science in the era of translational research.

Galactoxylomannans from Cryptococcus neoformans varieties neoformans and grubii are structurally and antigenically variable.

Microbial threat lists: obstacles in the quest for biosecurity?

Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo.

Antibodies against immunodominant antigens of Mycobacterium tuberculosis in subjects with suspected tuberculosis in the United States compared by HIV status.

The influence of proteasome inhibitor MG132, external radiation, and unlabeled antibody on the tumor uptake and biodistribution of (188)re-labeled anti-E6 C1P5 antibody in cervical cancer in mice.

Extracellular vesicles from Cryptococcus neoformans modulate macrophage functions.

Hark back: passive immunotherapy for influenza and other serious infections.

Paramecium species ingest and kill the cells of the human pathogenic fungus Cryptococcus neoformans.

Circular Dichroism reveals evidence of coupling between immunoglobulin constant and variable region secondary structure.

Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism.

Neutralizing monoclonal antibody to edema toxin and its effect on murine anthrax.

Melanin-covered nanoparticles for protection of bone marrow during radiation therapy of cancer.

Cryptococci at the brain gate: break and enter or use a Trojan horse?

Immunomodulatory effects of serotype B glucuronoxylomannan from Cryptococcus gattii correlate with polysaccharide diameter.

Characterization of yeast extracellular vesicles: evidence for the participation of different pathways of cellular traffic in vesicle biogenesis.

Destruction of microbial collections in response to select agent and toxin list regulations.

Fungal cell gigantism during mammalian infection.

Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection.

Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin.

Phagocytosis of Cryptococcus neoformans by, and nonlytic exocytosis from, Acanthamoeba castellanii.

ASM Launches mBio.

Global warming will bring new fungal diseases for mammals.

An insight into the antifungal pipeline: selected new molecules and beyond.

Intracellular cryptococci suppress Fc-mediated cyclin D1 elevation.

Role of CD45 signaling pathway in galactoxylomannan-induced T cell damage.

Radioimmunotherapy with an antibody to the HPV16 E6 oncoprotein is effective in an experimental cervical tumor expressing low levels of E6.

Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major.

A requirement for FcγR in antibody-mediated bacterial toxin neutralization.

Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins.

Correlation between serum and plasma antibody titers to mycobacterial antigens.

Mammalian endothermy optimally restricts fungi and metabolic costs.

On immunologists and microbiologists: ground zero in the battle for interdisciplinary knowledge.

A new design for the ASM general meeting.

Glucuronoxylomannan, galactoxylomannan, and mannoprotein occupy spatially separate and discrete regions in the capsule of Cryptococcus neoformans.

Evidence for branching in cryptococcal capsular polysaccharides and consequences on its biological activity.

Evaluation of Cryptococcus neoformans galactoxylomannan-protein conjugate as vaccine candidate against murine cryptococcosis.

Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line.

Reductionistic and holistic science.

Biogenesis of extracellular vesicles in yeast: Many questions with few answers.

Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.

The F-Box protein Fbp1 regulates sexual reproduction and virulence in Cryptococcus neoformans.

Role for Golgi reassembly and stacking protein (GRASP) in polysaccharide secretion and fungal virulence.

Gamma radiation interacts with melanin to alter its oxidation-reduction potential and results in electric current production.

Phospholipids trigger Cryptococcus neoformans capsular enlargement during interactions with amoebae and macrophages.

The effect of L-DOPA on Cryptococcus neoformans growth and gene expression.

On immunologists and microbiologists: ground zero in the battle for interdisciplinary knowledge.

Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections.

Microbial virulence as an emergent property: consequences and opportunities.

Retracted science and the retraction index.

Nonlytic exocytosis of Cryptococcus neoformans from macrophages occurs in vivo and is influenced by phagosomal pH.

Cryptococcus neoformans galactoxylomannan is a potent negative immunomodulator, inspiring new approaches in anti-inflammatory immunotherapy.

Fungal polysaccharides: biological activity beyond the usual structural properties.

Cryptococcus neoformans capsular enlargement and cellular gigantism during Galleria mellonella infection.

Ten challenges on Cryptococcus and cryptococcosis.

Protection of melanized Cryptococcus neoformans from lethal dose gamma irradiation involves changes in melanin's chemical structure and paramagnetism.

Methylxanthine inhibit fungal chitinases and exhibit antifungal activity.

Chronological aging is associated with biophysical and chemical changes in the capsule of Cryptococcus neoformans.

Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice.

Biophysical methods for the study of microbial surfaces.

Bioterrorism: lessons learned since the anthrax mailings.

Vesicular transport systems in fungi.

Amoeba provide insight into the origin of virulence in pathogenic fungi.

Comparative evaluation of profiles of antibodies to mycobacterial capsular polysaccharides in tuberculosis patients and controls stratified by HIV status.

Synthesis and assembly of fungal melanin.

A new synthesis for antibody-mediated immunity.

Reforming science: methodological and cultural reforms.

Reforming science: structural reforms.

Analysis of cell cycle and replication of mouse macrophages after in vivo and in vitro Cryptococcus neoformans infection using laser scanning cytometry.

Capsules from pathogenic and non-pathogenic Cryptococcus spp. manifest significant differences in structure and ability to protect against phagocytic cells.

In vitro measurement of phagocytosis and killing of Cryptococcus neoformans by macrophages.

Quorum sensing in fungi--a review.

Serum albumin disrupts Cryptococcus neoformans and Bacillus anthracis extracellular vesicles.

Q and A: What is a pathogen? A question that begs the point.

Policy: Adaptations of avian flu virus are a cause for concern.

The H5N1 manuscript redaction controversy.

Public health and biosecurity. Adaptations of avian flu virus are a cause for concern.

Strain-related differences in antibody-mediated changes in gene expression are associated with differences in capsule and location of binding.

Fungal melanins differ in planar stacking distances.

Mammalian-transmissible H5N1 virus: containment level and case fatality ratio.

Pre-clinical evaluation of a 213Bi-labeled 2556 antibody to HIV-1 gp41 glycoprotein in HIV-1 mouse models as a reagent for HIV eradication.

The future of biological warfare.

Mouse models for the study of fungal pneumonia: a collection of detailed experimental protocols for the study of Coccidioides, Cryptococcus, Fusarium, Histoplasma and combined infection due to Aspergillus-Rhizopus.

Chitin-like molecules associate with Cryptococcus neoformans glucuronoxylomannan to form a glycan complex with previously unknown properties.

Recent progress in vaccines against fungal diseases.

Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases.

Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans.

Using solid-state NMR to monitor the molecular consequences of Cryptococcus neoformans melanization with different catecholamine precursors.

Monoclonal antibodies and toxins--a perspective on function and isotype.

Immunoglobulin isotype influences affinity and specificity.

The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies.

Winner takes all.

Fungi and the rise of mammals.

Variable region identical immunoglobulins differing in isotype express different paratopes.

EDTA inhibits biofilm formation, extracellular vesicular secretion, and shedding of the capsular polysaccharide glucuronoxylomannan by Cryptococcus neoformans.

A Paracoccidioides brasiliensis glycan shares serologic and functional properties with cryptococcal glucuronoxylomannan.

Misconduct accounts for the majority of retracted scientific publications.

The H5N1 moratorium controversy and debate.

Compton scattering by internal shields based on melanin-containing mushrooms provides protection of gastrointestinal tract from ionizing radiation.

Melanoma stem cells in experimental melanoma are killed by radioimmunotherapy.

Antibody binding to Cryptococcus neoformans impairs budding by altering capsular mechanical properties.

The microbial capsular polysaccharide galactoxylomannan inhibits IL-17A production in circulating T cells from rheumatoid arthritis patients.

Males are overrepresented among life science researchers committing scientific misconduct.

Exserohilum rostratum fungal meningitis associated with methylprednisolone injections.

Antibody-mediated immunity against tuberculosis: implications for vaccine development.

Combinations of monoclonal antibodies to anthrax toxin manifest new properties in neutralization assays.

The transcriptional response of Cryptococcus neoformans to ingestion by Acanthamoeba castellanii and macrophages provides insights into the evolutionary adaptation to the mammalian host.

Complement-dependent cytotoxicity of an antibody to melanin in radioimmunotherapy of metastatic melanoma.

Immunogenicity of mycobacterial vesicles in humans: identification of a new tuberculosis antibody biomarker.

Allergen1 regulates polysaccharide structure in Cryptococcus neoformans.

Disease-enhancing antibodies improve the efficacy of bacterial toxin-neutralizing antibodies.

Binding of the wheat germ lectin to Cryptococcus neoformans chitooligomers affects multiple mechanisms required for fungal pathogenesis.

Nontoxic radioactive Listeria(at) is a highly effective therapy against metastatic pancreatic cancer.

Fungal virulence in a lepidopteran model is an emergent property with deterministic features.

The constant region affects antigen binding of antibodies to DNA by altering secondary structure.

Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis.

The role of host gender in the pathogenesis of Cryptococcus neoformans infections.

Why has the number of scientific retractions increased?

Global structures of IgG isotypes expressing identical variable regions.

Progress in understanding fungal pathogenesis.

Temporal behavior of capsule enlargement by Cryptococcus neoformans.

Is the Nobel Prize good for science?

Insights into fungal pathogenesis from the iatrogenic epidemic of Exserohilum rostratum fungal meningitis.

Radioimmunotherapy of Cryptococcus neoformans spares bystander mammalian cells.

The intracellular life of Cryptococcus neoformans.

Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.

Microbicidal power of alpha radiation in sterilizing germinating Bacillus anthracis spores.

Quorum sensing-mediated, cell density-dependent regulation of growth and virulence in Cryptococcus neoformans.

Redaction of sensitive data in the publication of dual use research of concern.

Molecular determinants for a cardiovascular collapse in anthrax.

The presence of female conveners correlates with a higher proportion of female speakers at scientific symposia.

Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity.

Role for Mycobacterium tuberculosis membrane vesicles in iron acquisition.

Specialized science.

Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage.

Cryptococcus neoformans glucuronoxylomannan fractions of different molecular masses are functionally distinct.

Characterization of Alternaria infectoria extracellular vesicles.

The tools for virulence of Cryptococcus neoformans.

AIDS-related mycoses: the way forward.

Temporal kinetics and quantitative analysis of Cryptococcus neoformans nonlytic exocytosis.

Causes for the persistence of impact factor mania.

On the need for a national board to assess dual use research of concern.

Pigment production on L-tryptophan medium by Cryptococcus gattii and Cryptococcus neoformans.

Characterization of protective extracellular membrane-derived vesicles produced by Streptococcus pneumoniae.

A role for LHC1 in higher order structure and complement binding of the Cryptococcus neoformans capsule.

Extracellular vesicles produced by the Gram-positive bacterium Bacillus subtilis are disrupted by the lipopeptide surfactin.

Interaction of Cryptococcus neoformans extracellular vesicles with the cell wall.

Sources of error in the retracted scientific literature.

Capsule growth in Cryptococcus neoformans is coordinated with cell cycle progression.

Demonstration of a common indole-based aromatic core in natural and synthetic eumelanins by solid-state NMR.

Risks and benefits of gain-of-function experiments with pathogens of pandemic potential, such as influenza virus: a call for a science-based discussion.

Financial costs and personal consequences of research misconduct resulting in retracted publications.

An epistemological perspective on the value of gain-of-function experiments involving pathogens with pandemic potential.

Reply to "a brain drain due to increased regulation of influenza virus research is highly speculative".

Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis.

Role of B Cells and Antibodies in Acquired Immunity against Mycobacterium tuberculosis.

The Decision to Publish an Avian H7N1 Influenza Virus Gain-of-Function Experiment.

Reply to "can limited scientific value of potential pandemic pathogen experiments justify the risks?".

Reply to "Valuing Knowledge: a Reply to the Epistemological Perspective on the Value of Gain-of-Function Experiments".

The Apocalypse as a Rhetorical Device in the Influenza Virus Gain-of-Function Debate.

The importance of virology at a time of great need and great jeopardy.

A new synthesis for dual use research of concern.

The Ebola epidemic crystallizes the potential of passive antibody therapy for infectious diseases.

Achieving Speaker Gender Equity at the American Society for Microbiology General Meeting.

Dual-Use Research of Concern (DURC) Review at American Society for Microbiology Journals.

Increasing disparities between resource inputs and outcomes, as measured by certain health deliverables, in biomedical research.

The Justification for the Academy Track in mBio.

Role of Cln1 during melanization of Cryptococcus neoformans.

Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi.

Field Science--the Nature and Utility of Scientific Fields.

(A)Historical science.

Infectious Diseases Society of America and Gain-of-Function Experiments With Pathogens Having Pandemic Potential.

Virulence-Associated Enzymes of Cryptococcus neoformans.

Impacted science: impact is not importance.

Reply to Fiscella: The phases of biomedical research should be studied to optimize health outcomes.

Activation of Melanin Synthesis in Alternaria infectoria by Antifungal Drugs.

Fungal Melanin: What do We Know About Structure?

Ig Constant Region Effects on Variable Region Structure and Function.

NIH peer review percentile scores are poorly predictive of grant productivity.

Enhanced virulence of Histoplasma capsulatum through transfer and surface incorporation of glycans from Cryptococcus neoformans during co-infection.

Revolutionary Science.

Cryptococcal therapies and drug targets: the old, the new and the promising.

Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction.

Research Funding: the Case for a Modified Lottery.

The Holobiont/Hologenome Concept Series.

Grant funding: Playing the odds.

Erratum for Fang and Casadevall, Research Funding: the Case for a Modified Lottery.

The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination Against Mycobacterium tuberculosis.

The Prevalence of Inappropriate Image Duplication in Biomedical Research Publications.

Zika Virus Focuses the Gain-of-Function Debate.

Antibody Binding Alters the Characteristics and Contents of Extracellular Vesicles Released by Histoplasma capsulatum.

The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection.

ASM Journals Eliminate Impact Factor Information from Journal Websites.

ASM Journals Eliminate Impact Factor Information from Journal Websites.

ASM Journals Eliminate Impact Factor Information from Journal Websites.

ASM Journals Eliminate Impact Factor Information from Journal Websites.

ASM Journals Eliminate Impact Factor Information from Journal Websites.

ASM Journals Eliminate Impact Factor Information from Journal Websites.

ASM Journals Eliminate Impact Factor Information from Journal Websites.

ASM Journals Eliminate Impact Factor Information from Journal Websites.

A Framework for Improving the Quality of Research in the Biological Sciences.

Moonshot Science-Risks and Benefits.

Reply to "Funding by Lottery: Political Problems and Research Opportunities".

Revisiting the Immunoglobulin Intramolecular Signaling Hypothesis.

To Be or Not Be a (Functional) Antibody Against TB.

Extracellular vesicles from Paracoccidioides brasiliensis induced M1 polarization in vitro.

Reply to "Improving Microbiology Research: the Problems Are Less Statistical and More Biological".

ASM Journals Eliminate Impact Factor Information from Journal Websites.

Rigorous Science: a How-To Guide.

A Monoclonal Antibody to Cryptococcus neoformans Glucuronoxylomannan Manifests Hydrolytic Activity for Both Peptides and Polysaccharides.

Physiological Differences in Cryptococcus neoformans Strains In Vitro versus In Vivo and Their Effects on Antifungal Susceptibility.

Antibodies to Mycobacterium tuberculosis.

Reply to "On the Impact Factor and the ASM Editorial Policy".

The mBio American Academy of Microbiology Submission Track in 2017.

32-Phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect.

The Pathogenic Potential of a Microbe.

Melanin, Radiation, and Energy Transduction in Fungi.

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

Crisis in Infectious Diseases: 2 Decades Later.

Continental Drift and Speciation of the Cryptococcus neoformans and Cryptococcus gattii Species Complexes.

Fungi that Infect Humans.

Reply to Engelthaler and Meyer, "Furthering the Continental Drift Speciation Hypothesis in the Pathogenic Cryptococcus Species Complexes".

Antibody-Mediated Catalysis in Infection and Immunity.

Microbial melanins for radioprotection and bioremediation.

Support Science by Publishing in Scientific Society Journals.

N-acetylglucosamine affects Cryptococcus neoformans cell-wall composition and melanin architecture.

WHAT IS A HOST II: THE ATTRIBUTES OF INDIVIDUAL SUSCEPTIBILITY.

Divalent metal cations potentiate the predatory capacity of amoeba for Cryptococcus neoformans.

Erratum for Schloss et al., "Support Science by Publishing in Scientific Society Journals".

Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects.

Immune-Mediated Damage Completes the Parabola: Cryptococcus neoformans Pathogenesis Can Reflect the Outcome of a Weak or Strong Immune Response.

Graduate Biomedical Science Education Needs a New Philosophy.

Reply to Argüelles and Argüelles-Prieto, "Are the Editors Responsible for Our Obsession with the Impact Factor?"

The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans.