Silvia C. Finnemann

The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium.

Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors.

Comment on 'Integrin alphavbbeta is not required for the phagocytosis of photoreceptor outer segments by cultured retinal pigment epithelial cells' by M.O. Hall, T.A. Abrams and B.L. Burgess [Exp. Eye Res. 77 (2003) 281-286].

Role of alphavbeta5 integrin in regulating phagocytosis by the retinal pigment epithelium.

Changes in retinal pigment epithelial gene expression induced by rod outer segment uptake.

Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin.

Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors.

Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peak.

Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions.

Altered rhythm of photoreceptor outer segment phagocytosis in beta5 integrin knockout mice.

MerTK activation during RPE phagocytosis in vivo requires alphaVbeta5 integrin.

The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells.

Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.

Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis.

Alphavbeta5 integrin receptors at the apical surface of the RPE: one receptor, two functions.

Lack of alphavbeta5 integrin receptor or its ligand MFG-E8: distinct effects on retinal function.

The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells.

Neural retina and MerTK-independent apical polarity of alphavbeta5 integrin receptors in the retinal pigment epithelium.

Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin.

Expression of the integrin coreceptor transglutaminase-2 in the RPE in vivo and in culture.

αvβ5 integrin-dependent diurnal phagocytosis of shed photoreceptor outer segments by RPE cells is independent of the integrin coreceptor transglutaminase-2.

Essential diurnal Rac1 activation during retinal phagocytosis requires αvβ5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase.

Retinal pigment epithelial cells use a MerTK-dependent mechanism to limit the phagocytic particle binding activity of αvβ5 integrin.

Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina.

Analysis of photoreceptor rod outer segment phagocytosis by RPE cells in situ.

Analysis of photoreceptor outer segment phagocytosis by RPE cells in culture.

PI 3-kinase independent role for AKT in F-actin regulation during outer segment phagocytosis by RPE cells.

Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and as antioxidant in retinal pigment epithelial cells.

Lack of effect of microfilament or microtubule cytoskeleton-disrupting agents on restriction of externalized phosphatidylserine to rod photoreceptor outer segment tips.

Understanding photoreceptor outer segment phagocytosis: use and utility of RPE cells in culture.