Stephan M. Jakob

ARDS. Monitoring tissue perfusion.

Effect of dopamine-induced changes in splanchnic blood flow on MEGX production from lidocaine in septic and cardiac surgery patients.

Effects of dopamine on systemic and regional blood flow and metabolism in septic and cardiac surgery patients.

Splanchnic vasoregulation during mesenteric ischemia and reperfusion in pigs.

Acute normovolemic hemodilution improves oxygenation in ischemic flap tissue.

Clinical review: splanchnic ischaemia.

Splanchnic blood flow in low-flow states.

Change in stroke volume in response to fluid challenge: assessment using esophageal Doppler.

Apparent heterogeneity of regional blood flow and metabolic changes within splanchnic tissues during experimental endotoxin shock.

Changes in regional blood flow and pCO(2) gradients during isolated abdominal aortic blood flow reduction.

Diagnosis and management of electrolyte emergencies.

Changes in splanchnic circulation during an alveolar recruitment maneuver in healthy porcine lungs.

Measuring depth of sedation with auditory evoked potentials during controlled infusion of propofol and remifentanil in healthy volunteers.

N100 auditory potential and electroencephalogram discriminate propofol-induced sedation levels.

Midlatency auditory-evoked potentials in the assessment of sedation in cardiac surgery patients.

Blindness in the intensive care unit.

Blood pressure and vessel recanalization in the first hours after ischemic stroke.

Estimation of central venous pressure by ultrasound.

Hepatosplanchnic blood flow control and oxygen extraction are modified by the underlying mechanism of impaired perfusion.

Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment.

Severe acute pancreatitis: case-oriented discussion of interdisciplinary management.

Comparison of continuous and intermittent renal replacement therapy for acute renal failure.

Preconditioning with monophosphoryl lipid A improves survival of critically ischemic tissue.

Does fluid loading influence measurements of intestinal permeability?

Reversible encephalopathy complicating post-streptococcal glomerulonephritis.

Effects of low abdominal blood flow and dobutamine on blood flow distribution and on the hepatic arterial buffer response in anaesthetized pigs.

Decreasing gut wall glucose as an early marker of impaired intestinal perfusion.

Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function.

Membrane microdialysis: Evaluation of a new method to assess splanchnic tissue metabolism.

The effects of dexmedetomidine/remifentanil and midazolam/remifentanil on auditory-evoked potentials and electroencephalogram at light-to-moderate sedation levels in healthy subjects.

Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study.

Effect of endotoxin, dobutamine and dopamine on muscle mitochondrial respiration in vitro.

Arterio-venous gradients of free energy change for assessment of systemic and splanchnic perfusion in cardiac surgery patients.

Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock.

Intraperitoneal microdialysis: critique of an editorial.

Sedation and weaning from mechanical ventilation: effects of process optimization outside a clinical trial.

Tonometry revisited: perfusion-related, metabolic, and respiratory components of gastric mucosal acidosis in acute cardiorespiratory failure.

Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow.

Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo.

The immediate and sustained effects of volume challenge on regional blood flows in pigs.

Development and simultaneous application of multiple care protocols in critical care: a multicenter feasibility study.

Orthogonal polarization spectroscopy to detect mesenteric hypoperfusion.

Thermodilution and esophageal Doppler ultrasound in the assessment of blood flow changes induced by endotoxin and dobutamine.

Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration.

Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation.

Entropy and bispectral index for assessment of sedation, analgesia and the effects of unpleasant stimuli in critically ill patients: an observational study.

Inverse thermodilution with conventional pulmonary artery catheters for the assessment of cerebral, hepatic, renal, and femoral blood flow.

Increased splanchnic oxygen extraction because of routine nursing procedures.

Shedding light on microcirculation?

Arterial blood pressure during early sepsis and outcome.

Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study.

Assessment of splanchnic blood flow using magnetic resonance imaging.

Different patterns of Siglec-9-mediated neutrophil death responses in septic shock.

Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study.

Norepinephrine-induced hypertension dilates vasospastic basilar artery after subarachnoid haemorrhage in rabbits.

Elevated level of endothelin-1 in cerebrospinal fluid and lack of nitric oxide in basilar arterial plasma associated with cerebral vasospasm after subarachnoid haemorrhage in rabbits.

Physical and occupational therapy during sedation stops.

Evaluation of physical and mental recovery status after elective liver resection.

Septic shock resuscitation: what goals and how to achieve them?

Peri-operative adrenocortical response to low-dose (1 microg) ACTH and relation to postoperative complications in patients undergoing elective abdominal surgery.

Effects of endotoxin and catecholamines on hepatic mitochondrial respiration.

Treatment of acute renal failure in the intensive care unit: lower costs by intermittent dialysis than continuous venovenous hemodiafiltration.

Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients.

Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes.

Usefulness of a clinical diagnosis of ICU-acquired paresis to predict outcome in patients with SIRS and acute respiratory failure.

Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study.

Effect of fluid resuscitation on mortality and organ function in experimental sepsis models.

Perioperative metabolic changes in patients undergoing cardiac surgery.

The effects of mechanical ventilation on hepato-splanchnic perfusion.

Effects of lung recruitment maneuvers on splanchnic organ perfusion during endotoxin-induced pulmonary arterial hypertension.

Splanchnic vasoregulation after major abdominal surgery in pigs.

Physiologic response to changing positive end-expiratory pressure during neurally adjusted ventilatory assist in sedated, critically ill adults.

500 ml of blood loss does not decrease non-invasive tissue oxygen saturation (StO2) as measured by near infrared spectroscopy - A hypothesis generating pilot study in healthy adult women.

Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions.

Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study.

Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study.

Increasing abdominal pressure with and without PEEP: effects on intra-peritoneal, intra-organ and intra-vascular pressures.

Extra-intracranial blood shunt mimicking aneurysm rupture: intracranial-pressure-controlled rabbit subarachnoid hemorrhage model.

Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes.

Review article: improving outcome after major surgery: pathophysiological considerations.

Brain herniation in a patient with apparently normal intracranial pressure: a case report.

Does hypercapnic acidosis preserve mucosal oxygenation during hemorrhage?

Current approach to the haemodynamic management of septic shock patients in European intensive care units: a cross-sectional, self-reported questionnaire-based survey.

Comparison of non-calibrated pulse-contour analysis with continuous thermodilution for cardiac output assessment in patients with induced hypothermia after cardiac arrest.

Comparison of porcine and human coagulation by thrombelastometry.

CO(2)-Dependent vasomotor reactivity of cerebral arteries in patients with severe traumatic brain injury: time course and effect of augmentation of cardiac output with dobutamine.

Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs.

Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo.

Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: a multi-center randomized controlled trial.

Dimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivo.

Traumatic subarachnoid hemorrhage, basal ganglia hematoma and ischemic stroke caused by a torn lenticulostriate artery.

Postoperative splanchnic blood flow redistribution in response to fluid challenges in the presence and absence of endotoxemia in a porcine model.

Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems.

Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes.

Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.

Effects of cardiac preload reduction and dobutamine on hepatosplanchnic blood flow regulation in porcine endotoxemia.

A new rabbit model for the study of early brain injury after subarachnoid hemorrhage.

The role of androgens on hypoxia-inducible factor (HIF)-1α-induced angiogenesis and on the survival of ischemically challenged skin flaps in a rat model.

Randomized, double-blind trial of the effect of fluid composition on electrolyte, acid-base, and fluid homeostasis in patients early after subarachnoid hemorrhage.

Effect of treatment delay on disease severity and need for resuscitation in porcine fecal peritonitis.

Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes.

Haemodynamic variables and functional outcome in hypothermic patients following out-of-hospital cardiac arrest.

Mitochondrial function in sepsis.

Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC.

No evidence for a local renin-angiotensin system in liver mitochondria.

Sedation level and prevalence of delirium: response to Brummel and Ely.

Different contribution of splanchnic organs to hyperlactatemia in fecal peritonitis and cardiac tamponade.

Angiotensin II in septic shock: effects on tissue perfusion, organ function, and mitochondrial respiration in a porcine model of fecal peritonitis.

Interference of angiotensin II and enalapril with hepatic blood flow regulation.

Early changes of muscle membrane properties in porcine faecal peritonitis.