Gregory L. Szot

Inability to induce tolerance through direct antigen presentation.

Targeting and blocking B7 costimulatory molecules on antigen-presenting cells using CTLA4Ig-conjugated liposomes: in vitro characterization and in vivo factors affecting biodistribution.

IL-6 protects pancreatic islet beta cells from pro-inflammatory cytokines-induced cell death and functional impairment in vitro and in vivo.

Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.

Innate immunity and intestinal microbiota in the development of Type 1 diabetes.

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.

Expansion of human regulatory T-cells from patients with type 1 diabetes.

Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.

Successful clinical islet isolation using a GMP-manufactured collagenase and neutral protease.

Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.

Clinical islet transplantation at the University of California, San Francisco.