Christopher H. Contag

Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter.

Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging.

Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles.

Advances in in vivo bioluminescence imaging of gene expression.

It's not just about anatomy: in vivo bioluminescence imaging as an eyepiece into biology.

Visualization of effective tumor targeting by CD8+ natural killer T cells redirected with bispecific antibody F(ab')(2)HER2xCD3.

Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation.

Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging.

Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1.

Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4.

Animal models of bone metastasis.

Understanding immune cell trafficking patterns via in vivo bioluminescence imaging.

Dual-axis confocal microscope for high-resolution in vivo imaging.

Optical monitoring and treatment of potentially lethal wound infections in vivo.

In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors.

Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in utero.

Adoptive cellular gene therapy of autoimmune disease.

A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice.

Gene transfer via reversible plasmid condensation with cysteine-flanked, internally spaced arginine-rich peptides.

Evaluation of effector cell fate and function by in vivo bioluminescence imaging.

Advancing molecular therapies through in vivo bioluminescent imaging.

Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection.

Treatment of autoimmune disease by adoptive cellular gene therapy.

Effects of metalloporphyrins on heme oxygenase-1 transcription: correlative cell culture assays guide in vivo imaging.

Shifting foci of hematopoiesis during reconstitution from single stem cells.

Breaching biological barriers: protein translocation domains as tools for molecular imaging and therapy.

p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia.

Extracellular replication of Listeria monocytogenes in the murine gall bladder.

A genetic reporter of thermal stress defines physiologic zones over a defined temperature range.

Assessment of cellular response to thermal laser injury through bioluminescence imaging of heat shock protein 70.

The E47 transcription factor negatively regulates CD5 expression during thymocyte development.

In vivo bioluminescence imaging for integrated studies of infection.

Adipose-derived adult stromal cells heal critical-size mouse calvarial defects.

Multi-modality imaging identifies key times for annexin V imaging as an early predictor of therapeutic outcome.

Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals.

Molecular medicine: the writing is on the vessel wall.

Confocal fluorescence microscope with dual-axis architecture and biaxial postobjective scanning.

Apoptosis in a rodent model of cranial suture fusion: in situ imaging and gene expression analysis.

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer.

Monitoring age-related susceptibility of young mice to oral Salmonella enterica serovar Typhimurium infection using an in vivo murine model.

In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets.

Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation, osteoclast recruitment, and bone turnover.

Adoptive transfer of mast cells does not enhance the impaired survival of Kit(W)/Kit(W-v) mice in a model of low dose intraperitoneal infection with bioluminescent Salmonella typhimurium.

Small hairpin RNAs efficiently inhibit hepatitis C IRES-mediated gene expression in human tissue culture cells and a mouse model.

Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cells.

Real-time in vivo imaging of stem cells following transgenesis by transposition.

Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury.

Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation.

Breast-milk shedding of drug-resistant HIV-1 subtype C in women exposed to single-dose nevirapine.

In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury.

Emission spectra of bioluminescent reporters and interaction with mammalian tissue determine the sensitivity of detection in vivo.

The effectiveness of oral tin mesoporphyrin prophylaxis in reducing bilirubin production after an oral heme load in a transgenic mouse model.

Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction.

Ex vivo expanded dendritic cells home to T-cell zones of lymphoid organs and survive in vivo after allogeneic bone marrow transplantation.

New enzyme for reductive cancer chemotherapy, YieF, and its improvement by directed evolution.

Selective intratumoral amplification of an antiangiogenic vector by an oncolytic virus produces enhanced antivascular and anti-tumor efficacy.

Induced biliary excretion of Listeria monocytogenes.

Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production.

Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer cells with bispecific antibodies: a preclinical study.

Synergistic antitumor effects of immune cell-viral biotherapy.

Systemic effects of orally-administered zinc and tin (IV) metalloporphyrins on heme oxygenase expression in mice.

Options for visualizing metastatic disease in the living body.

Intracellular cargo delivery by an octaarginine transporter adapted to target prostate cancer cells through cell surface protease activation.

Releasable luciferin-transporter conjugates: tools for the real-time analysis of cellular uptake and release.

In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease.

Luciferin derivatives for enhanced in vitro and in vivo bioluminescence assays.

Expression and regulation of heme oxygenase isozymes in the developing mouse cortex.

Spatiotemporal expression of heme oxygenase-1 detected by in vivo bioluminescence after hepatic ischemia in HO-1/Luc mice.

Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease.

Dual-axes confocal reflectance microscope for distinguishing colonic neoplasia.

In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation.

Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice.

Molecular imaging using visible light to reveal biological changes in the brain.

Donor CD8+ T cells mediate graft-versus-leukemia activity without clinical signs of graft-versus-host disease in recipients conditioned with anti-CD3 monoclonal antibody.

Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner.

The potential Salmonella aroA- vaccine strain is safe and effective in young BALB/c mice.

Delivery and inhibition of reporter genes by small interfering RNAs in a mouse skin model.

Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice.

Accelerated bone repair after plasma laser corticotomies.

Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium.

Methods for imaging cell fates in hematopoiesis.

Development of therapeutic siRNAs for pachyonychia congenita.

Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopy.

Single-nucleotide-specific siRNA targeting in a dominant-negative skin model.

Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathology.

Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs.

In vivo pathology: seeing with molecular specificity and cellular resolution in the living body.

Image-guided analyses reveal that non-CD4 splenocytes contribute to CD4+ T cell-mediated inflammation leading to islet destruction by altering their local function and not systemic trafficking patterns.

Design and evaluation of a variable aperture collimator for conformal radiotherapy of small animals using a microCT scanner.

Regulation of maternal and fetal hemodynamics by heme oxygenase in mice.

Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy.

Enhancing poxvirus oncolytic effects through increased spread and immune evasion.

Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors.

Three-dimensional in vivo imaging by a handheld dual-axes confocal microscope.

In vivo analysis of heat-shock-protein-70 induction following pulsed laser irradiation in a transgenic reporter mouse.

Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architecture.

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters.

Sustained release of drugs dispersed in polymer nanoparticles.

Comparison of different adult stem cell types for treatment of myocardial ischemia.

Chemical control of protein stability and function in living mice.

Stability study of unmodified siRNA and relevance to clinical use.

In-vivo optical imaging of hsp70 expression to assess collateral tissue damage associated with infrared laser ablation of skin.

Development of an optimized activatable MMP-14 targeted SPECT imaging probe.

Foci of Listeria monocytogenes persist in the bone marrow.

CNOB/ChrR6, a new prodrug enzyme cancer chemotherapy.

Fibered confocal microscopy of bladder tumors: an ex vivo study.

Quantifying cell-surface biomarker expression in thick tissues with ratiometric three-dimensional microscopy.

Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart.

Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells.

Integrated studies of biology: multiplexed imaging assays from molecules to man and back.

Early detection of oral neoplasia: watching with new eyes.

TOB1 is regulated by EGF-dependent HER2 and EGFR signaling, is highly phosphorylated, and indicates poor prognosis in node-negative breast cancer.

The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals.

The importance of being red.

Use of an endoscope-compatible probe to detect colonic dysplasia with Fourier transform infrared spectroscopy.

Laser-induced disruption of systemically administered liposomes for targeted drug delivery.

FTIR microspectroscopy for improved prostate cancer diagnosis.

Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction.

Guided by the light: visualizing biomolecular processes in living animals with bioluminescence.

Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.

Nanoparticle formation of organic compounds with retained biological activity.

A general method for conditional regulation of protein stability in living animals.

Role of nitric oxide in Salmonella typhimurium-mediated cancer cell killing.

Fiber-optic probes enable cancer detection with FTIR spectroscopy.

Micromirror-scanned dual-axis confocal microscope utilizing a gradient-index relay lens for image guidance during brain surgery.

IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy.

Silencing of reporter gene expression in skin using siRNAs and expression of plasmid DNA delivered by a soluble protrusion array device (PAD).

Targeting localized immune suppression within the tumor through repeat cycles of immune cell-oncolytic virus combination therapy.

Assessing delivery and quantifying efficacy of small interfering ribonucleic acid therapeutics in the skin using a dual-axis confocal microscope.

Biodegradable nanoparticles with sustained release of functional siRNA in skin.

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models.

In vivo micro-image mosaicing.

Definition of an enhanced immune cell therapy in mice that can target stem-like lymphoma cells.

In vivo bioluminescence imaging of inducible nitric oxide synthase gene expression in vascular inflammation.

Non-damaging retinal phototherapy: dynamic range of heat shock protein expression.

Longitudinal, noninvasive imaging of T-cell effector function and proliferation in living subjects.

Development of quantitative molecular clinical end points for siRNA clinical trials.

In vivo imaging of human and mouse skin with a handheld dual-axis confocal fluorescence microscope.

Use of self-delivery siRNAs to inhibit gene expression in an organotypic pachyonychia congenita model.

Components of a curriculum for molecular imaging scientists.

Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis.

Image-guided genomic analysis of tissue response to laser-induced thermal stress.

Heme oxygenase-1 deletion affects stress erythropoiesis.

Point-of-care pathology with miniature microscopes.

Pulse duration determines levels of Hsp70 induction in tissues following laser irradiation.

Molecular imaging of inflammation and carcinogenesis.

In vivo sustained release of siRNA from solid lipid nanoparticles.

Comparing an optical parametric oscillator (OPO) as a viable alternative for mid-infrared tissue ablation with a free electron laser (FEL).

Infection of pregnant mice with Listeria monocytogenes induces fetal bradycardia.

Visualization of plasmid delivery to keratinocytes in mouse and human epidermis.

Generic and personalized RNAi-based therapeutics for a dominant-negative epidermal fragility disorder.

In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract.

Inhibition of CD44 gene expression in human skin models, using self-delivery short interfering RNA administered by dissolvable microneedle arrays.

Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice.

Interrogation of inhibitor of nuclear factor κB α/nuclear factor κB (IκBα/NF-κB) negative feedback loop dynamics: from single cells to live animals in vivo.

Identification of cell surface targets through meta-analysis of microarray data.

Intravital fluorescence imaging of small interfering RNA-mediated gene repression in a dual reporter melanoma xenograft model.

Femtosecond plasma mediated laser ablation has advantages over mechanical osteotomy of cranial bone.

Advancing the translation of optical imaging agents for clinical imaging.

Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept.

Microscopic Delineation of Medulloblastoma Margins in a Transgenic Mouse Model Using a Topically Applied VEGFR-1 Probe.

Real-time pathology through in vivo microscopy.

Visualizing cellular interactions with a generalized proximity reporter.

A Raman-based endoscopic strategy for multiplexed molecular imaging.

Noninvasive imaging of hypoxia-inducible factor-1α gene therapy for myocardial ischemia.

Monitoring dynamic interactions between breast cancer cells and human bone tissue in a co-culture model.

High-sensitivity, real-time, ratiometric imaging of surface-enhanced Raman scattering nanoparticles with a clinically translatable Raman endoscope device.

Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device.

Reporter gene technologies for imaging cell fates in hematopoiesis.

Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein.

A killer choice for cancer immunotherapy.

[(99m)Tc]Annexin V-128 SPECT Monitoring of Splenic and Disseminated Listeriosis in Mice: a Model of Imaging Sepsis.

Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging.

Differential fates of biomolecules delivered to target cells via extracellular vesicles.

Detection of Non-Melanoma Skin Cancer by in vivo Fluorescence Imaging with Fluorocoxib A.