Carl Cotman

Caspase-3 activation as a bifurcation point between plasticity and cell death.

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.

Exercise enhances and protects brain function.

The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties.

Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility.

Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain.

Exercise: a behavioral intervention to enhance brain health and plasticity.

Achieving and maintaining cognitive vitality with aging.

Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum.

Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.

Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome.

Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction.

Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice.

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain.

Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging.

The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain.

Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid.

Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous.

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.

Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion.

Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death.

Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease.

Locomotor activity rhythms in dogs vary with age and cognitive status.

Response latency in Canis familiaris: mental ability or mental strategy?

Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease.

Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs.

The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise.

Isolated executive impairment and associated frontal neuropathology.

Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks.

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology.

Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons.

Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury.

Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging.

Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats.

Patterned cell culture inside microfluidic devices.

The exercise-induced expression of BDNF within the hippocampus varies across life-span.

Voluntary wheel running improves recovery from a moderate spinal cord injury.

Activation of complement pathways after contusion-induced spinal cord injury.

Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats.

The role of caspase cleavage of tau in Alzheimer disease neuropathology.

A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog.

Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs.

Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.

Exercise-induced gene expression changes in the rat spinal cord.

Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.

A microfluidic culture platform for CNS axonal injury, regeneration and transport.

Nutritional management of brain aging in dogs.

The role of neurotrophins in brain aging: a perspective in honor of Regino Perez-Polo.

BioVision: an application for the automated image analysis of histological sections.

Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men.

Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.

Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia.

Neurobiology of exercise.

Musashi1 antigen expression in human fetal germinal matrix development.

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease.

External force-assisted cell positioning inside microfluidic devices.

Region specific neuron loss in the aged canine hippocampus is reduced by enrichment.

Effects of melatonin and age on gene expression in mouse CNS using microarray analysis.

Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid.

Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains.

Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth.

Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction.

Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function.

Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse.

Exercise builds brain health: key roles of growth factor cascades and inflammation.

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers.

Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons.

Voluntary running attenuates age-related deficits following SCI.

Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction.

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid.

Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines.

Gene expression changes in the course of normal brain aging are sexually dimorphic.

Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.

Healthy brain aging: a meeting report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging.

The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches.

Axonal mRNA in uninjured and regenerating cortical mammalian axons.

β-Amyloid impairs axonal BDNF retrograde trafficking.

Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice.

Physical activity and the maintenance of cognition: learning from animal models.

Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles.

Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells.

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines.

BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog.

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta.

Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia.

Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines.

Microfluidic Multicompartment Device for Neuroscience Research.

Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease.

Mild stress facilitates learning and exercise improves retention in aged mice.

Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs.

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

An amyloid β(42)-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease.

Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain.

Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.

Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ɛ4 carriers.