Leslie Dan Faculty of Pharmacy,
Institute of Biomaterials and Biomedical Engineering
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"Swollen" Macrocycles: Palladium(II)-Directed Template Syntheses of Pendant-Arm 14-, 16-, and 18-Membered Macrocycles.
Inorganic chemistry Aug, 1996 | Pubmed ID: 11666700
Polymer-drug compatibility: a guide to the development of delivery systems for the anticancer agent, ellipticine.
Journal of pharmaceutical sciences Jan, 2004 | Pubmed ID: 14648643
pH gradient loading of anthracyclines into cholesterol-free liposomes: enhancing drug loading rates through use of ethanol.
Biochimica et biophysica acta Feb, 2004 | Pubmed ID: 14967474
Synthesis and characterization of biodegradable poly(ethylene glycol)-block-poly(5-benzyloxy-trimethylene carbonate) copolymers for drug delivery.
Biomacromolecules Sep-Oct, 2004 | Pubmed ID: 15360292
Engineering lipobeads: properties of the hydrogel core and the lipid bilayer shell.
Biomacromolecules Nov-Dec, 2004 | Pubmed ID: 15530037
Monodisperse chitosan nanoparticles for mucosal drug delivery.
Biomacromolecules Nov-Dec, 2004 | Pubmed ID: 15530064
Influence of serum protein on polycarbonate-based copolymer micelles as a delivery system for a hydrophobic anti-cancer agent.
Journal of controlled release : official journal of the Controlled Release Society Mar, 2005 | Pubmed ID: 15763628
In vitro and in vivo characterization of a novel biocompatible polymer-lipid implant system for the sustained delivery of paclitaxel.
Journal of controlled release : official journal of the Controlled Release Society May, 2005 | Pubmed ID: 15866344
Synthesis and characterization of six-arm star poly(delta-valerolactone)-block-methoxy poly(ethylene glycol) copolymers.
Biomacromolecules Jul-Aug, 2005 | Pubmed ID: 16004456
How well are we caring for caregivers? Prevalence of grief-related symptoms and need for bereavement support among long-term care staff.
Journal of pain and symptom management Sep, 2005 | Pubmed ID: 16183006
Methoxy poly(ethylene glycol)-block-poly(delta-valerolactone) copolymer micelles for formulation of hydrophobic drugs.
Biomacromolecules Nov-Dec, 2005 | Pubmed ID: 16283736
Liposome formulation of a novel hydrophobic aryl-imidazole compound for anti-cancer therapy.
Cancer chemotherapy and pharmacology Sep, 2006 | Pubmed ID: 16333677
Multimodal contrast agent for combined computed tomography and magnetic resonance imaging applications.
Investigative radiology Mar, 2006 | Pubmed ID: 16481918
Epidermal growth factor-conjugated poly(ethylene glycol)-block- poly(delta-valerolactone) copolymer micelles for targeted delivery of chemotherapeutics.
Bioconjugate chemistry Mar-Apr, 2006 | Pubmed ID: 16536472
Synthesis and physicochemical and dynamic mechanical properties of a water-soluble chitosan derivative as a biomaterial.
Biomacromolecules Oct, 2006 | Pubmed ID: 17025361
Impact of intraperitoneal, sustained delivery of paclitaxel on the expression of P-glycoprotein in ovarian tumors.
Journal of controlled release : official journal of the Controlled Release Society Jan, 2007 | Pubmed ID: 17113177
Synthesis and physicochemical and dynamic mechanical properties of a water-soluble chitosan derivative as a biomaterial.
Biomacromolecules Dec, 2006 | Pubmed ID: 17154488
In vivo fate of unimers and micelles of a poly(ethylene glycol)-block-poly(caprolactone) copolymer in mice following intravenous administration.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V Mar, 2007 | Pubmed ID: 17257817
In vivo performance of a liposomal vascular contrast agent for CT and MR-based image guidance applications.
Pharmaceutical research Jun, 2007 | Pubmed ID: 17373581
Novel biocompatible intraperitoneal drug delivery system increases tolerability and therapeutic efficacy of paclitaxel in a human ovarian cancer xenograft model.
Cancer chemotherapy and pharmacology Nov, 2007 | Pubmed ID: 17375303
Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: relating plasma circulation lifetimes to protein binding.
Biochimica et biophysica acta Jun, 2007 | Pubmed ID: 17400180
Long-circulating poly(ethylene glycol)-coated emulsions to target solid tumors.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V Sep, 2007 | Pubmed ID: 17490868
Predicting the solubility of the anti-cancer agent docetaxel in small molecule excipients using computational methods.
Pharmaceutical research Jan, 2008 | Pubmed ID: 17705028
Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy.
Molecular pharmaceutics Sep-Oct, 2007 | Pubmed ID: 17867644
Diblock copolymer micelles deliver hydrophobic protoporphyrin IX for photodynamic therapy.
Photochemistry and photobiology Nov-Dec, 2007 | Pubmed ID: 18028227
Nano-sized assemblies of a PEG-docetaxel conjugate as a formulation strategy for docetaxel.
Journal of pharmaceutical sciences Aug, 2008 | Pubmed ID: 18064681
Drug release mechanism of paclitaxel from a chitosan-lipid implant system: effect of swelling, degradation and morphology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V May, 2008 | Pubmed ID: 18164931
Effects of sustained and intermittent paclitaxel therapy on tumor repopulation in ovarian cancer.
Molecular cancer therapeutics Mar, 2008 | Pubmed ID: 18347149
Influence of molecular organization and interactions on drug release for an injectable polymer-lipid blend.
International journal of pharmaceutics Aug, 2008 | Pubmed ID: 18550303
Intermolecular interactions and morphology of aqueous polymer/surfactant mixtures containing cationic chitosan and nonionic sorbitan esters.
Biomacromolecules Aug, 2008 | Pubmed ID: 18605692
Morphological control of poly(ethylene glycol)-block-poly(epsilon-caprolactone) copolymer aggregates in aqueous solution.
Biomacromolecules Sep, 2008 | Pubmed ID: 18702541
Quantitative CT imaging of the spatial and temporal distribution of liposomes in a rabbit tumor model.
Molecular pharmaceutics Mar-Apr, 2009 | Pubmed ID: 19298061
Block copolymer micelles for delivery of cancer therapy: transport at the whole body, tissue and cellular levels.
Journal of controlled release : official journal of the Controlled Release Society Sep, 2009 | Pubmed ID: 19376167
Biocompatibility of injectable chitosan-phospholipid implant systems.
Biomaterials Aug, 2009 | Pubmed ID: 19394688
Chitosan-phospholipid blend for sustained and localized delivery of docetaxel to the peritoneal cavity.
International journal of pharmaceutics Jul, 2009 | Pubmed ID: 19442712
Cellular uptake and transport of gold nanoparticles incorporated in a liposomal carrier.
Nanomedicine : nanotechnology, biology, and medicine Feb, 2010 | Pubmed ID: 19447206
Intracellular uptake, transport, and processing of nanostructures in cancer cells.
Nanomedicine : nanotechnology, biology, and medicine Jun, 2009 | Pubmed ID: 19480047
Sixth International Nanomedicine and Drug Delivery Symposium (NanoDDS'08).
Journal of controlled release : official journal of the Controlled Release Society Sep, 2009 | Pubmed ID: 19567258
Enhancement of docetaxel solubility via conjugation of formulation-compatible moieties.
Organic & biomolecular chemistry Sep, 2009 | Pubmed ID: 19675898
Noninvasive monitoring of the fate of 111In-labeled block copolymer micelles by high resolution and high sensitivity microSPECT/CT imaging.
Molecular pharmaceutics Mar-Apr, 2009 | Pubmed ID: 19718806
Multifunctional block copolymer micelles for the delivery of 111In to EGFR-positive breast cancer cells for targeted Auger electron radiotherapy.
Molecular pharmaceutics Feb, 2010 | Pubmed ID: 19924993
In vivo distribution of polymeric nanoparticles at the whole-body, tumor, and cellular levels.
Pharmaceutical research Nov, 2010 | Pubmed ID: 20195708
Poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles containing chemically conjugated and physically entrapped docetaxel: synthesis, characterization, and the influence of the drug on micelle morphology.
Biomacromolecules May, 2010 | Pubmed ID: 20369884
Polymeric drug delivery systems for localized cancer chemotherapy.
Drug delivery Aug, 2010 | Pubmed ID: 20429844
The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles.
Molecular pharmaceutics Aug, 2010 | Pubmed ID: 20476759
Utility of transdermal fentanyl for prevention of iatrogenic opioid abstinence syndrome in children.
Journal of opioid management Mar-Apr, 2010 | Pubmed ID: 20481176
Gold nanoparticles as radiation sensitizers in cancer therapy.
Radiation research Jun, 2010 | Pubmed ID: 20518651
Continuous docetaxel chemotherapy improves therapeutic efficacy in murine models of ovarian cancer.
Molecular cancer therapeutics Jun, 2010 | Pubmed ID: 20530719
Liposome contrast agent for CT-based detection and localization of neoplastic and inflammatory lesions in rabbits: validation with FDG-PET and histology.
Contrast media & molecular imaging May-Jun, 2010 | Pubmed ID: 20586032
Combination drug delivery strategy for the treatment of multidrug resistant ovarian cancer.
Molecular pharmaceutics Feb, 2011 | Pubmed ID: 21166459
Docetaxel distribution following intraperitoneal administration in mice.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques , 2011 | Pubmed ID: 21501556
Chemotherapy dosing schedule influences drug resistance development in ovarian cancer.
Molecular cancer therapeutics Jul, 2011 | Pubmed ID: 21551263
Hydrogels Containing Core Cross-Linked Block Co-Polymer Micelles.
Journal of biomaterials science. Polymer edition , 2012 | Pubmed ID: 21619728
APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes.
Journal of controlled release : official journal of the Controlled Release Society Sep, 2011 | Pubmed ID: 21640146
Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery.
Nanomedicine : nanotechnology, biology, and medicine Jan, 2012 | Pubmed ID: 21669300
Influence of formulation variables on the biodistribution of multifunctional block copolymer micelles.
Journal of controlled release : official journal of the Controlled Release Society Feb, 2012 | Pubmed ID: 21982897
An injectable depot system for sustained intraperitoneal chemotherapy of ovarian cancer results in favorable drug distribution at the whole body, peritoneal and intratumoral levels.
Journal of controlled release : official journal of the Controlled Release Society Mar, 2012 | Pubmed ID: 22154933
Block copolymer micelles target Auger electron radiotherapy to the nucleus of HER2-positive breast cancer cells.
Biomacromolecules Feb, 2012 | Pubmed ID: 22191486
Recent advances in drug delivery strategies for treatment of ovarian cancer.
Expert opinion on drug delivery May, 2012 | Pubmed ID: 22452661
Neurologic withdrawal symptoms following abrupt discontinuation of a prolonged dexmedetomidine infusion in a child.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG Jan, 2010 | Pubmed ID: 22477791
Differential role of organic anion-transporting polypeptides in estrone-3-sulphate uptake by breast epithelial cells and breast cancer cells.
The Journal of pharmacology and experimental therapeutics Aug, 2012 | Pubmed ID: 22588260
Neoplastic cell response to tiopronin-coated gold nanoparticles.
Nanomedicine : nanotechnology, biology, and medicine Feb, 2013 | Pubmed ID: 22687897
Hydrogel containing silica shell cross-linked micelles for ocular drug delivery.
Journal of pharmaceutical sciences Nov, 2012 | Pubmed ID: 23203974
Comparison of computed tomography- and optical image-based assessment of liposome distribution.
Molecular imaging May, 2013 | Pubmed ID: 23490441
Multicellular tumor spheroids for evaluation of cytotoxicity and tumor growth inhibitory effects of nanomedicines in vitro: a comparison of docetaxel-loaded block copolymer micelles and Taxotere®.
PloS one , 2013 | Pubmed ID: 23626842
Estrone-3-sulphate, a potential novel ligand for targeting breast cancers.
PloS one , 2013 | Pubmed ID: 23717534
A novel minimally invasive technique to create a rabbit VX2 lung tumor model for nano-sized image contrast and interventional studies.
PloS one , 2013 | Pubmed ID: 23840673
Thermosensitive depot-forming injectable phosphatidylcholine blends tailored for localized drug delivery.
Journal of pharmaceutical sciences Oct, 2013 | Pubmed ID: 23873505
Continuous intraperitoneal carboplatin delivery for the treatment of late-stage ovarian cancer.
Molecular pharmaceutics Sep, 2013 | Pubmed ID: 23924289
Tumor perfusion imaging predicts the intra-tumoral accumulation of liposomes.
Journal of controlled release : official journal of the Controlled Release Society Nov, 2013 | Pubmed ID: 24021358
Active targeting of block copolymer micelles with trastuzumab Fab fragments and nuclear localization signal leads to increased tumor uptake and nuclear localization in HER2-overexpressing xenografts.
Molecular pharmaceutics Nov, 2013 | Pubmed ID: 24066900
The impact of sustained and intermittent docetaxel chemotherapy regimens on cognition and neural morphology in healthy mice.
Psychopharmacology Mar, 2014 | Pubmed ID: 24101158
Multi-arm PEG/silica hydrogel for sustained ocular drug delivery.
Journal of pharmaceutical sciences Jan, 2014 | Pubmed ID: 24285503
A mathematical model of the enhanced permeability and retention effect for liposome transport in solid tumors.
PloS one , 2013 | Pubmed ID: 24312530
Image-based analysis of the size- and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts.
International journal of pharmaceutics Apr, 2014 | Pubmed ID: 24440400
Heat-activated thermosensitive liposomal cisplatin (HTLC) results in effective growth delay of cervical carcinoma in mice.
Journal of controlled release : official journal of the Controlled Release Society Mar, 2014 | Pubmed ID: 24440663
Expression of membrane transporters and metabolic enzymes involved in estrone-3-sulphate disposition in human breast tumour tissues.
Breast cancer research and treatment Jun, 2014 | Pubmed ID: 24831777
The challenges facing block copolymer micelles for cancer therapy: In vivo barriers and clinical translation.
Advanced drug delivery reviews Aug, 2015 | Pubmed ID: 25308250
Hypoxia and cellular localization influence the radiosensitizing effect of gold nanoparticles (AuNPs) in breast cancer cells.
Radiation research Nov, 2014 | Pubmed ID: 25361396
(125)I-Labelled 2-Iodoestrone-3-sulfate: synthesis, characterization and OATP mediated transport studies in hormone dependent and independent breast cancer cells.
Nuclear medicine and biology Mar, 2015 | Pubmed ID: 25542669
Spatial and temporal mapping of heterogeneity in liposome uptake and microvascular distribution in an orthotopic tumor xenograft model.
Journal of controlled release : official journal of the Controlled Release Society Jun, 2015 | Pubmed ID: 25862513
Development of a liposome formulation for improved biodistribution and tumor accumulation of pentamidine for oncology applications.
International journal of pharmaceutics Jul, 2015 | Pubmed ID: 25910415
The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation.
Journal of controlled release : official journal of the Controlled Release Society Aug, 2015 | Pubmed ID: 26070245
The Global Burden of Cancer 2013.
JAMA oncology Jul, 2015 | Pubmed ID: 26181261
A multimodal nano agent for image-guided cancer surgery.
Biomaterials Oct, 2015 | Pubmed ID: 26218742
Effects of Doxorubicin Delivery Systems and Mild Hyperthermia on Tissue Penetration in 3D Cell Culture Models of Ovarian Cancer Residual Disease.
Molecular pharmaceutics Nov, 2015 | Pubmed ID: 26394060
Integration of imaging into clinical practice to assess the delivery and performance of macromolecular and nanotechnology-based oncology therapies.
Journal of controlled release : official journal of the Controlled Release Society Dec, 2015 | Pubmed ID: 26403800
Preclinical imaging and translational animal models of cancer for accelerated clinical implementation of nanotechnologies and macromolecular agents.
Journal of controlled release : official journal of the Controlled Release Society Dec, 2015 | Pubmed ID: 26409122
592: VANCOMYCIN DOSING AND PHARMACOKINETICS IN POSTOPERATIVE PEDIATRIC CARDIOTHORACIC SURGERY PATIENTS.
Critical care medicine Dec, 2015 | Pubmed ID: 26570253
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements.
Advanced drug delivery reviews Dec, 2015 | Pubmed ID: 26712711
Vancomycin Dosing and Pharmacokinetics in Postoperative Pediatric Cardiothoracic Surgery Patients.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG Jan-Feb, 2016 | Pubmed ID: 26997930
Dual Action Enhancement of Gold Nanoparticle Radiosensitization by Pentamidine in Triple Negative Breast Cancer.
Radiation research May, 2016 | Pubmed ID: 27135970
Thermosensitive liposomal cisplatin in combination with local hyperthermia results in tumor growth delay and changes in tumor microenvironment in xenograft models of lung carcinoma.
Journal of drug targeting Jun, 2016 | Pubmed ID: 27310112
Why I'm Holding onto Hope for Nano in Oncology.
Molecular pharmaceutics Aug, 2016 | Pubmed ID: 27404330
The burden of cancer in Mexico, 1990-2013.
Salud pública de México Apr, 2016 | Pubmed ID: 27557370
Yannan N. Dou1,
Robert A. Weersink2,5,
Warren D. Foltz5,6,
Jinzi Zheng5,6,
Naz Chaudary7,
David A. Jaffray2,3,4,5,6,
Christine Allen1
1Leslie Dan Faculty of Pharmacy, University of Toronto,
2Department of Radiation Oncology, University of Toronto,
3Medical Biophysics, University of Toronto,
4Institute of Biomaterials & Biomedical Engineering, University of Toronto,
5Techna Institute and Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network,
6STTARR Innovation Center, University Health Network,
7Ontario Cancer Institute, University Health Network
Shawn Stapleton1,2,3,
Daniel Mirmilshteyn2,
Jinzi Zheng3,4,
Christine Allen2,4,5,
David A. Jaffray1,2,3,4,5,6
1Department of Medical Biophysics, University of Toronto,
2Leslie Dan Faculty of Pharmacy, University of Toronto,
3STTARR Innovation Centre, Princess Margaret Cancer Centre,
4Institute of Biomaterials and Biomedical Engineering, University of Toronto,
5Techna Institute, University Health Network,
6Radiation Medicine Program, Princess Margaret Cancer Centre
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